Most humans in modern societies are cardio-metabolically stressed and therefore suffer adverse cardiovascular and metabolic effects depending on exposure, genetics, life-style and ageing. Significantly, 80% of people who develop the metabolic problem of diabetes die because of the cardiovascular complications caused by their diabetes. The complications are aggressive types of cardiovascular disease which increasingly feature in middle age and are more difficult to treat than cardiovascular disease in the absence of diabetes. As well as premature death, the complications lead to disabilities, reduced ability to work and reduced quality of life. The heart is impacted but the important vascular component means that implications span the whole body, ranging from intolerance to physical exercise, lower limb ulceration, accelerated arthritis, impaired auditory and visual acuity, renal failure, sexual dysfunction and dementia. The scale of this problem is truly enormous and strongly anticipated to increase in the UK and globally (https://www.bhf.org.uk/research/heart-statistics, http://www.who.int/mediacentre/factsheets/fs312/en/). For UK finances, the burden is 10% of the National Health Service (NHS) budget and set to increase. Critically, current treatment options are limited and largely fail to address the problem.