Cardio Metabolic Research at Leeds

Atherothrombosis and Diabetes

 

 

Atherothrombosis and diabetes

 

This group focuses on understanding the molecular basis of the tight biological link between diabetes and atherothrombotic vascular disease using model systems to develop translational approaches that modulate these disorders in man. Discoveries made by the group include: Understanding genetic contributions to thrombotic phenotypes; Interaction between acetylation and glycation to explain reduced cardioprotective properties of aspirin in diabetes.

 

Investigators

 

 

Ramzi Ajjan
Ramzi Ajjan

The bulk of the current work is focussed on analysing the effects of genetic variations in clotting factors (mainly fibrinogen and factor XIII) on clot structure and function using recombinant techniques.

Staff webpage

Robert Ariens
Robert Ariens

I have found that the 3D structure of the fibrin clot is different in patients with coronary artery disease. My research is focussed on mechanisms that regulate clot structure and how resilient it is, with the aim to develop new diagnostics and therapeutics for thrombosis.

Staff Webpage

Paul Baxter
Paul Baxter

My research involves the use of large cardiovascular disease registries and advanced biostatistical methods to understand the drivers of patient outcomes and disease mechanisms.

Staff webpage

Colin Fishwick
Colin Fishwick

Our research is focused on the application of computeraided molecular design methods to the production of potent and selective small-molecule inhibitors of a range of therapeutically important enzymes and receptors.

Staff webpage

Chris Gale

My research group utilises descriptive and analytical epidemiological techniques to better understand, undertake comparative effectiveness analyses and therefore improve the quality care of patients with cardiovascular disease.

Staff webpage

Peter Grant
Peter Grant

My research addresses the genetic and environmental determinants of fibrin structure/function in relation to insulin resistance, type 2 diabetes and cardiovascular disease.

Staff webpage

Kirti Kain
Kirti Kain

My research is focussed on studying relationships of blood pressures (and treatments) in different vascular beds to diabetes and cardiovascular diseases in south Asians.

Staff webpage

Stephen Muench

My research involves the combination of these techniques in order to understand the structure/function relationship of a number of medically important targets.

Staff webpage

Helen Philippou
Helen Philippou

My research is focused on understanding mechanisms of thrombosis by characterising the nature of end-stage coagulation protein-protein interactions, regulatory mechanisms and the influence of post-translational modifications of proteins in determining a blood clots resistance to fibrinolysis.

Staff webpage

Mar Pujades Rodriguez
Mar Pujades Rodriguez

My research focuses on understanding how to improve care of patients with chronic diseases and multimorbidity through the use of existing clinical trial and electronic health data sources. I am particularly interested in the evaluation of patient outcomes associated with treatment and the development of risk prediction models of benefits and harms of therapy that facilitate patient-physician shared decision making.

Staff webpage

Sikha Saha
Sikha Saha

My research focuses on cellular remodeling and metabolic profiling in stroke, atherosclerosis, diabetes and related cerebrovascular diseases to investigate novel targets and develop diagnostic tools.

Staff webpage

Eleanor Scott
Eleanor Scott

I study circadian influences on cardio-metabolic outcomes, including translational work on how 24 hour glucose control relates to adverse outcomes in women with diabetes in pregnancy.

Staff webpage

Julian Scott
Julian Scott

Staff webpage

Kerrie Smith
Kerrie Smith

My research focuses primarily on identifying the key residues involved in the binding of Factor XIII and Fibrinogen, and elucidating the functional role of such interactions in the generation of a stable fibrin clot. This work aims to provide novel targets for the development of anticoagulants.

Staff webpage

Paul Stewart
Paul Stewart

Professor Stewart supervises an active Endocrinology research group funded by renewed programme grant support from The Wellcome Trust, MRC, ARC grants and most recently an ERC Advanced Research Grant.

Staff webpage

What's Happening

18 January 2018: Bridging the gap between molecules and millimetres: In vivo assessment of myocardial microstructure and function using diffusion tensor CMR ... more

08 February 2018:  ... more

15 February 2018: MCRC Seminar ... more

Athena Swan