Cardio Metabolic Research at Leeds

Cardiovascular Engineering

 

 

Cardiovascular Engineering

 

This group focuses on the research, development, clinical translation and commercialisation of cardiovascular tissues with specific interests in heart valves, vascular patches and vascular grafts. Innovations by the Group include: Invention of the Vascutek bioprosthetic heart valve implanted in tens of thousands of patients world-wide; Development of acellular allogenic and xenogeneic aortic and pulmonary heart valve conduits. Acellular allogeneic heart valves are being translated into the clinic through clinical and commercial collaborators and pre-clinical proof of principle of the regenerative capacity of acellular xenogeneic cardiac valves has been demonstrated in large animal models, highlighting the role of macrophage.

 

Investigators

 

 

Eileen Ingham
Eileen Ingham

Research is focused on clinical and commercial translation of acellular allogeneic and xenogeneic cardiac valves and understanding of the mechanisms of acellular biological scaffold regeneration.

Staff webpage

John Fisher
John Fisher FMedSci

Research into acellular biological scaffolds for cardiovascular applications is focused on the development of innovative, robust preclinical bioengineering test methods to ensure safety and reliability.

Staff webpage

Shervanthi Homer-Vanniasinkam

Staff webpage

John Thomson

Staff webpage

Kevin Watterson

Staff webpage

Helen Berry

My research focus is on elucidating the mechanisms of immunomodulation and tissue regeneration in acellular scaffolds for cardiovascular repair and replacement, in conjunction with investigating translational issues such as bioprocessing and sterilisation methods. The clinical success of acellular scaffolds can be built upon by defining the mechanisms of action, and functional tolerances for natural matrix modification, to provide insight for new scaffold development; whilst targeted bioprocessing methods and integrated sterilisation strategies will increase the opportunity for the applied research to be translated into clinical practice.

Staff webpage

Michael Colman
Michael Colman

Multi-scale mathematical modelling of cardiac function

Staff webpage

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What's Happening

25 October 2017: LICAMM Seminar ... more

26 October 2017: The translational pathway of pericyte toward clinical use in patients with myocardial ischemia ... more

27 October 2017: Studying dynamic protein structure by native MS and ion mobility: From protein disorder to membrane pores ... more

Athena Swan