Cardio Metabolic Research at Leeds

Heart Failure and Autonomic Control

 

Cardiac Muscle and Neuronal Control

This group primarily investigates control of the heart; from nervous control to the myocardium itself. Its investigations are conducted at many levels, from molecular and cellular studies (including cardiac myocytes and fibroblasts) to the intact heart, through to assessment of autonomic function in human subjects and computer simulations. Interests encompass cardiac function in health and disease (e.g. heart failure, hypoxia). Topics include caveolar modulation of signalling in the cardiac myocyte, sarcoplasmic reticulum and nuclear calcium signalling, regulation of cardiac fibroblast function, neuronal circuits controlling sympathetic and parasympathetic outflow and their effects of cardiovascular function, electrical, mechanical and structural interactions in the myocardium and their remodelling in disease, as well as remodelling in the vasculature and effects of hypoxia on neuronal and vascular function.

 

Investigators

 

Scott Bowen

My research is focussed on understanding the mechanisms that mediate skeletal muscle loss and weakness, and how therapeutic strategies such as exercise training and small-molecule inhibitors can be applied to help overcome such impairments in various clinical conditions such as heart failure.

Sarah Calaghan
Dr Sarah Calaghan

My research focuses on the mechanisms which control the behaviour of individual cardiac muscle cells in the heart in response to a variety of stimuli. This information can be used to understand the function of the heart in both health and disease.

Staff webpage

John Colyer
Professor John Colyer

My group is interested in the control of cardiac function via post-translational modification (PTM) of proteins. We use quantitative approaches to explore these events in health and disease.

Staff webpage

Jim Deuchars
Professor Jim Deuchars

Our basic research investigates the organisation and function of the parts of the brain and spinal cord that contribute to control of the cardiovascular. Our human work applies that knowledge with therapeutic intentions, utilising neuromodulation to correct cardiovascular disorders.

Staff webpage

Susan Deuchars
Susan Deuchars

I study how cells within the spinal cord fit into complex and specialised neuronal circuits associated with autonomic control, with a special interest in whether newly born cells in the adult spinal cord can integrate into these circuits.

Staff webpage

Mark Drinkhill
Picture

My research focuses on the autonomic control of cardiovascular system and how disease processes such as heart failure can adversely influence this.

Staff webpage

Carrie Ferguson
Carrie image

We are interested in understanding the integrated physiological responses that limit exercise tolerance, how exercise testing can be used to stratify patient care and how exercise can be used to ameliorate exercise tolerance.

Staff Webpage

Richard Foster
Dr Richard Foster

My group is interested in the design, synthesis and optimisation of small molecules for therapeutic application or their use in the elucidation of biological function.

Staff webpage

Alistair Hall
Professor Alistair Hall

This regional network works to discover, develop and deploy effective strategies to: Identify and understand the mechanism of coronary artery disease. Prevent premature coronary artery disease.

Staff webpage

David Hauton

My research examines the role of oxygen in the control of metabolism and mechanical function of the heart, with particular interest in the diabetic and failing heart. This has wider implications for the function of skeletal muscles and may contribute to changes in the ability to exercise.

Isuru Jayasinghe
Isuru Jayasinghe

My research focuses on the development and application of super-resolution microscopy technologies in studying the structures, biomolecules and their function within muscle cells of the heart's chambers. In particular, I am interested in advancing our spatial understanding of the intracellular membrane compartments, ion channels and other signalling molecules within the cells. With super-resolution microscopy methods, I observe and track these components at nanometre precision in order make careful calculations of the protein-to-protein interactions and the resulting calcium signals that underpin the contractile performance of the healthy and failing heart.

Staff Webpage

Matthew Lancaster

Dr Matthew Lancaster

 

We investigate the progressive changes in the pacemaker and ventricles of the heart with advancing age, which then predispose to problems in old age.

Staff webpage

Chris Peers
Professor Chris Peers

Studies are focused on how physiological gases (oxygen, carbon monoxide and hydrogen sulphide) directly regulate ion channel function and hence various aspects of disease associated vascular smooth muscle and cardiac myocyte activity.

Staff webpage

Sheena Radford
Professor Sheena Radford

Current major projects include:

 

  • Mechanism(s) of protein self-assembly into amyloid
  • Membrane protein folding (mechanism and role of chaperones)
  • Stabilising proteins of therapeutic interest against aggregation
  • Method development (MS, NMR, single molecule methods)

Staff webpage

Andrew Smith
Andrew Smith

My interest is in the role played by endogenous cardiac stem cells (eCSCs) within the myocardium and their contribution to tissue in both normal myocardial function and in disease.

Staff Webpage

Derek Steele
Professor Derek Steele

Most of my work addresses the sarcoplasmic reticulum Ca2+ channel (ryanodine receptor) in cardiac and skeletal muscle.

Staff webpage

John Trinick
Professor John Trinick

We study structure and mechanism in muscle sarcomeres and their isolated component proteins. This includes dilated and hypertrophic cardiomyopathies caused by sarcomere mutations. We specialise in electron microscopy.

Staff webpage

Neil Turner
Dr Neil Turner

The general aim of my research is to understand key intracellular signalling mechanisms that regulate adverse remodelling of the cardiovascular system, with particular focus on cardiac fibroblasts.

Staff webpage

Ed White
Ed White

We investigate the electrophysiological and contractile changes that occur in cardiac muscle in response to physiological (exercise) and pathological (heart failure) stimuli.

Staff webpage

Klaus Witte
Dr Klaus Witte

My work focuses broadly on the field of heart failure. My interests include the development of pathways to improve patient access to clinical services, and strategies to promote optimal use of existing drug and device treatments, as well as investigating novel new treatments.

Staff webpage

Ian Wood
Dr Ian Wood

My group is interested in understanding the mechanisms responsible for altered regulation of gene expression in cardiovascular disease.

Staff webpage

What's Happening

18 January 2018: Bridging the gap between molecules and millimetres: In vivo assessment of myocardial microstructure and function using diffusion tensor CMR ... more

08 February 2018:  ... more

15 February 2018: MCRC Seminar ... more

Athena Swan