Cardio Metabolic Research at Leeds

Cardiovascular Chemistry: Technology Group

 

This group focuses on the design, synthesis and optimisation of small molecules for therapeutic application or for their use in the elucidation of biological function. By combining tools and techniques in medicinal chemistry, chemical biology, computer-aided drug design and high-throughput screening we aim to identify and optimise targeted small molecules as key modulators of specific biological function to support both basic target validation and as potential starting points for the development of new drugs.

 

Investigators

 

Colin Fishwick
Colin Fishwick

Computer-aided design and subsequent synthesis of drug-like molecules directed against important therapeutic targets including antibacterial, antimalarial, antithrombotic, anti-Alzheimer's agents and anti-cancer agents. Development of new synthetic methods based around 1,3-dipolar, and hetero Diels-Alder cycloadditions.

Use of synthetic 'probe' molecules in the study of biological structure and function.

Staff webpage

Richard Foster
Dr Richard Foster

My research interests lie in the design, synthesis and optimisation of small molecules for therapeutic application or their use in the elucidation of biological function. By combining tools and techniques in medicinal chemistry, high-throughput screening, combinatorial chemistry, and computational-aided drug design we aim to identify and optimise targeted small molecules as key modulators of specific biological function.

Staff webpage

Adam Nelson
Adam Nelson

My research interests are focused on the application of synthetic organic chemistry to biological problems. Much of our research is undertaken in collaboration with colleagues from the Astbury Centre, and researchers in the group receive in-depth training at the interface between chemistry and biology. Synthesis is an immensely powerful tool in chemical biology, which we exploit in the directed evolution of enzymes as tailored catalysts for synthetic chemistry, and in the discovery of small molecular modulators of protein function.

Staff webpage

What's Happening

18 January 2018: Bridging the gap between molecules and millimetres: In vivo assessment of myocardial microstructure and function using diffusion tensor CMR ... more

08 February 2018:  ... more

15 February 2018: MCRC Seminar ... more

Athena Swan