This group focuses on the design, synthesis and optimisation of small molecules for therapeutic application or for their use in the elucidation of biological function. By combining tools and techniques in medicinal chemistry, chemical biology, computer-aided drug design and high-throughput screening we aim to identify and optimise targeted small molecules as key modulators of specific biological function to support both basic target validation and as potential starting points for the development of new drugs.
Computer-aided design and subsequent synthesis of drug-like molecules directed against important therapeutic targets including antibacterial, antimalarial, antithrombotic, anti-Alzheimer's agents and anti-cancer agents. Development of new synthetic methods based around 1,3-dipolar, and hetero Diels-Alder cycloadditions.
Use of synthetic 'probe' molecules in the study of biological structure and function.
My research interests lie in the design, synthesis and optimisation of small molecules for therapeutic application or their use in the elucidation of biological function. By combining tools and techniques in medicinal chemistry, high-throughput screening, combinatorial chemistry, and computational-aided drug design we aim to identify and optimise targeted small molecules as key modulators of specific biological function.
My research interests are focused on the application of synthetic organic chemistry to biological problems. Much of our research is undertaken in collaboration with colleagues from the Astbury Centre, and researchers in the group receive in-depth training at the interface between chemistry and biology. Synthesis is an immensely powerful tool in chemical biology, which we exploit in the directed evolution of enzymes as tailored catalysts for synthetic chemistry, and in the discovery of small molecular modulators of protein function.
25 October 2017: LICAMM Seminar ... more
26 October 2017: The translational pathway of pericyte toward clinical use in patients with myocardial ischemia ... more
27 October 2017: Studying dynamic protein structure by native MS and ion mobility: From protein disorder to membrane pores ... more