Multidisciplinary Cardiovascular Research Centre

Example original research papers

Greenwood, J.P., Maredia, N., Younger, J.F., Brown, J.M., Nixon, J., Everett, C.C., Bijsterveld, P., Ridgway, J.P., Radjenovic, A., Dickinson, C.J., Ball, S.G., Plein, S. (2012). Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial. Lancet 379, 453-460.

Scott, D.J., Prasad, P., Philippou, H., Rashid, S.T., Sohrabi, S., Whalley, D., Kordowicz, A., Tang, Q., West, R., Johnson, A., Woods, J., Ajjan, R.A., Ariëns, R.A. (2011). Clot Architecture Is Altered in Abdominal Aortic Aneurysms and Correlates With Aneurysm Size. Arterioscler Thromb Vasc Biol. 31, 3004-3010.

Uitte de Willige, S., Miedzak, M., Carter, A.M., Lisman, .T, Rosendaal, F.R., Grant, P.J., Philippou, H., Ariëns, R.A. (2011). Proteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction. Blood 117, 6694-6701.

Abbas, A., Imrie, H., Viswambharan, H., Sukumar, P., Rajwani, A., Cubbon, R., Gage, M., Smith, J., Galloway, S., Yuldeshava, N., Kahn, M., Xuan, S., Grant, P., Channon, K., Beech, D., Wheatcroft, S., Kearney, M. (2011). The Insulin-like Growth Factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium. Diabetes 60, 2169-2178.

Li, J., Cubbon, R.M., Wilson, L.A., Amer, M.S., McKeown, L., Hou, B., Majeed, Y., Tumova, S., Seymour, V.A.L., Taylor, H., Stacey, M., O’Regan, D., Foster, R., Porter, K.E., Kearney, M.T., Beech, D.J. (2011). Orai1 and CRAC channel dependence of VEGF-activated calcium entry and endothelial tube formation. Circulation Research 108, 1190-1198.

Cubbon, R.M., Gale, C.P., Kearney, L.C., Schechter, C.B., Brooksby, W.P., Nolan, J., Fox, K.A., Rajwani, A., Baig, W., Groves, D., Barlow, P., Fisher, A.C., Batin, P.D., Kahn, M.B., Zaman, A.G., Shah, A.M., Byrne, J.A., Lindsay, S.J., Sapsford, R.J., Wheatcroft, S.B., Witte, K.K., Kearney, M.T. (2011). Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras. Circ Heart Fail. 4, 396-403

Agarwal, S.R., MacDougall, D.A., Tyser, R., Pugh, S.D., Calaghan, S.C., Harvey, R.D. (2011). Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes. J Mol Cell Cardiol. 50, 500-509.

Smith, K.A., Adamson, P.J., Pease, R.J., Brown, J.M., Balmforth, A.J., Cordell, P.A., Ariëns, R.A., Philippou, H., Grant, P.J. (2011). Interactions between factor XIII and the alphaC region of fibrinogen. Blood 117, 3460-3468.

Kahn, M.B., Yuldasheva, N.Y., Cubbon, R.M., Surr, J., Rashid, S.T., Viswambharan, H., Imrie, H., Abbas, A., Rajwani, A., Aziz, A., Baliga, V., Sukumar, P., Gage, M., Kearney, M.T., Wheatcroft, S.B. (2011). Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration. Diabetes 60, 1295-303.

Cheong A, Li J, Sukumar P, Kumar B, Zeng F, Riches K, Munsch C, Wood IC, Porter KE, Beech DJ. (2011). Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by Kv1.3 channel blockers. Cardiovasc Res. 89, 282-289. See Press Release under News.

Bailey, K.M., Romaine, S.P., Jackson, B.M., Farrin, A.J., Efthymiou, M., Barth, J.H., Copeland, J., McCormack, T., Whitehead, A., Flather, M.D., Samani, N.J., Nixon, J., Hall, A.S., Balmforth, A.J. (2010). Hepatic Metabolism and Transporter Gene Variants Enhance Response to Rosuvastatin in Patients with Acute Myocardial Infarction - The GEOSTAT-1 Study. Circ Cardiovasc Genet. 3, 276-85.

Viswanathan, K., Kilcullen, N., Morrell, C., Thistlethwaite, S.J., Sivananthan, M.U., Hassan, T.B., Barth, J.H., Hall, A.S. (2010). Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin-negative. J Am Coll Cardiol. 55, 2590-2598.

Oke, O.A., Burgess, S.A., Forgacs, E., Knight, P.J., Sakamoto, T., Sellers, J.R., White, H., Trinick, J. (2010). Influence of lever structure on myosin 5a walking. Proc Natl Acad Sci U S A. 107, 2509-2514.

Mutch, N.J., Engel, R., Uitte de Willige, S., Philippou, H., Ariëns, R.A. (2010). Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin. Blood 115, 3980-3988.

AL-Shawaf, E., Naylor, J., Taylor, H., Riches, K., Milligan, C.J., O’Regan, D., Porter, K.E., Li, J., Beech, D.J. (2010). Stimulation of calcium-permeable TRPC5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol. 30, 1453-1459.

Cordell, P.A., Kile, B,T,, Standeven, K.F., Josefsson, E.C., Pease, R.J., Grant, P.J. (2010). Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion. Blood 115, 2674-2681.

Naylor, J., Li, J., Milligan, C.J., Zeng, F., Sukumar, P., Hou, B., Sedo, A., Yuldasheva, N., Majeed, Y., Beri, D., Jiang, S., Seymour, V.A.L., McKeown, L., Kumar, B., Harteneck, C., O'Regan, D., Wheatcroft, S.B., Kearney, M.T., Jones, C., Porter, K.E., Beech, D.J. (2010). Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circulation Research 106, 1507-1515.

Mughal, R.S., Scragg, J.L., Lister, P., Warburton, P., Riches, D.J., O'Regan, D., Ball, S.G., Turner, N.A, Porter, K.E. (2010). Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein. Diabetologia. 53, 1761-1771.

Cubbon, R.M., Murgatroyd, S.R., Ferguson, C., Bowen, T.S., Rakobowchuk, M., Baliga, V., Cannon, D., Rajwani, A., Abbas, A., Kahn, M., Birch, K.M., Porter, K.E., Wheatcroft, S.B., Rossiter, H.B., Kearney. M.T. (2010). Human exercise induced circulating progenitor cell mobilisation is nitric oxide dependent and is blunted in South Asian men. Arterioscler Thromb Vasc Biol. 30, 878-884.

Bruns, AF, Herbert, SP, Odell, AF, Jopling, HM, Hooper, NM, Zachary, IC, Walker, JH, Ponnambalam, S (2010) Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. Traffic, 11, 161-174.

*Muller, F., *Mutch, N.J., Schenk, W.A., Smith, S.A., Esterl, L., Spronk, H.M., Schmidbauer, S., Gahl, W.A., Morrissey, J.H., Renne, T. (2009). Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell 139, 1143-1156.

Herbert, S.P., Huisken, J., Kim, T.N., Feldman, M.E., Houseman, B.T., Wang, R.A., Shokat, K.M., Stainier, D.Y.R. (2009). Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation. Science 326, 294-298.

Ajjan, R.A., Standeven, K.F., Khanbhai, M., Phoenix, F., Gersh, K.C., Weisel, J.W., Kearney, M.T., Ariëns, R.A. & Grant, P,J. (2009). Effects of aspirin on clot structure and fibrinolysis using a novel in vitro cellular system. Arterioscler Thromb Vasc Biol. 29, 712-717.

Myocardial Infarction Genetics Consortium (2009). Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nature Genetics 41, 334-341.

Duncan, E., Crossey P., Walker, S., Anilkumar, N., Poston, L., Douglas, G., Ezzat, V., Wheatcroft, S., Shah, A.M., Kearney, M.T. (2008). The effect of endothelium specific insulin resistance on endothelial function in vivo. Diabetes 57, 3307-3314.

Derham, C., Yow, H., Ingram, J., Fisher, J., Ingham, E., Korrosis, S.A., Homer-Vanniasinkam, S. (2008). Tissue engineering small-diameter vascular grafts: preparation of a biocompatible porcine ureteric scaffold. Tissue Eng Part A 14,1871-1882.

Hyatt, C.J., Zemlin, C.W., Smith, R.M., Matiukas, A., Pertsov, A.M., Bernus, O. (2008). Reconstructing subsurface electrical wave orientation from cardiac epi-fluorescence recordings: Monte Carlo versus diffusion approximation. Opt. Express 16, 13758-13772.

Li, J., Sukumar, P., Milligan, C.J., Kumar, B., Ma, Z., Munsch, C.M., Jiang, L.H., Porter, K.E., Beech, D.J. (2008). Interactions, functions and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circulation Research 103, e97-104.

Murphy, J.E., Vohra, R.S., Dunn, S., Holloway, Z.G., Monaco, A.P., Homer-Vanniasinkam, S., Walker, J.H., Ponnambalam, S. (2008). Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2. J Cell Sci 121, 2136-2147.

Jung, H.S., Burgess, S.A., Billington, N., Colegrave, M., Patel, H., Chalovich, J.M., Chantler, P.D. & Knight, P.J. (2008). Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution. Proc Natl Acad Sci U S A 105, 6022-6026

Ajjan, R., Lim, B.C., Standeven, K.F., Harrand, R., Dolling, S., Phoenix, F., Greaves, R., Abou-Saleh, R.H., Connell, S., Smith, D.A., Weisel, J.W., Grant, P.J. & Ariëns, R.A. (2008). Common variation in the C-terminal region of the fibrinogen beta-chain: effects on fibrin structure, fibrinolysis and clot rigidity. Blood 111, 643-650.

Xu, S.Z., Sukumar, P., Zeng, F., Li, J., Jairaman, A., English, A., Naylor, J., Ciurtin, C., Majeed, Y., Milligan, C.J., Bahnasi, Y.M., AL-Shawaf, E., Porter, K.E., Jiang, L.H., Emery, P., Sivaprasadarao, A. & Beech, D.J. (2008). TRPC channel activation by extracellular thioredoxin.  Nature 451, 69-72.

Burns, J., Sivananthan, MU, Ball, S.G., Mackintosh, A.F., Mary, D.A.S.G. & Greenwood, J.P. (2007). The relationship between central sympathetic drive and MRI determined left ventricular mass in essential hypertension. Circulation 115, 1999-2005

Jones, S.A., Boyett, M.R. & Lancaster, M.K. (2007).  Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node. Circulation 115, 1183-1190.

Standeven, K.F., Carter, A.M., Grant, P.J., Weisel, J.W., Chernysh, I., Masova, L., Lord, S.T., Ariëns, R.A. (2007). Functional analysis of fibrin {gamma}-chain cross-linking by activated factor XIII: determination of a cross-linking pattern that maximizes clot stiffness. Blood 110, 902-907.

Wheatcroft, S.B., Kearney, M.T., Shah, A.M., Ezzat, V.A., Miell, J.R., Modo, M., Williams, S.C., Cawthorn, W.P., Medina-Gomez, G., Vidal-Puig, A., Sethi, J.K. & Crossey, P.A. (2007).  IGF-binding protein-2 protects against the development of obesity and insulin resistance. Diabetes 56, 285-294.

Xu, S.Z., Muraki, K., Zeng, F., Li, J., Sukumar, P., Shah, S.S., Dedman, A.M., Flemming, P.K., McHugh, D., Naylor, J., Cheong, A., Bateson, A.N., Munsch, C.M., Porter, K.E. & Beech, D.J. (2006).  A sphingosine-1-phosphate activated calcium channel controlling vascular smooth muscle cell motility.  Circulation Research 98, 1381-1389. 

Kumar, B., Dreja, K., Shah, S., Cheong, C., Xu, S., Sukumar, P., Naylor, J., Forta, A., Cipollaro, M., McHugh, D., Kingston, P.A., Heagerty, A.M., Munsch, C.M., Bergdahl, A., Hultgårdh-Nilsson, A., Gomez, M.F., Porter, K.E., Hellstrand, P. & Beech, D.J. (2006). Up-regulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia.  Circulation Research 98, 557-563.

Yang, Z. & Steele, D.S. (2005). Characteristics of prolonged Ca-release events associated with the nuclei in adult cardiac myocytes. Circulation Research 96, 82-90.

Cheong, A., Bingham, A.J., Li, J., Kumar, B., Sukumar, P., Munsch, C., Buckley, N.J., Neylon, C.B., Porter, K.E., Beech, D.J. & Wood, I.C. (2005). Down-regulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation.  Molecular Cell 20, 45-52.

The BHF Family Heart Study Research Group (2005). A genome wide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study. Am J Hum Genet 77, 1011 – 1020.