Cardio Metabolic Research at Leeds

 

Example original research papers

Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK. Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle. 2019 Aug 20. doi: 10.1002/jcsm.12488.

Hausenloy DJ et al. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial. Lancet. 2019 Sep 6. pii: S0140-6736(19)32039-2. doi: 10.1016/S0140-6736(19)32039-2.

Brittenden J, Cooper D, Dimitrova M, Scotland G, Cotton SC, Elders A, MacLennan G, Ramsay CR, Norrie J, Burr JM, Campbell B, Bachoo P, Chetter I, Gough M, Earnshaw J, Lees T, Scott J, Baker SA, Tassie E, Francis J, Campbell MK. Five-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins. N Engl J Med. 2019 Sep 5;381(10):912-922. doi: 10.1056/NEJMoa1805186

Blythe NM, Muraki K, Ludlow MJ, Stylianidis V, Gilbert HTJ, Evans EL, Cuthbertson K, Foster R, Swift J, Li J, Drinkhill MJ, van Nieuwenhoven FA, Porter KE, Beech DJ, Turner NA. Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. J Biol Chem. 2019 Oct 4. pii: jbc.RA119.009167. doi: 10.1074/jbc.RA119.009167. [Epub ahead of print]

Lotteau S, Ivarsson N, Yang Z, Restagno D, Colyer J, Hopkins P, Weightman A, Himori K, Yamada T, Bruton J, Steele D, Westerblad H, Calaghan S. Mechanism for Statin-Induced Susceptibility to Myopathy. JACC Basic Transl Sci. 2019 Aug 26;4(4):509-523. doi: 10.1016/j.jacbts.2019.03.012. eCollection 2019 Aug

Swoboda PP, Garg P, Levelt E, Broadbent DA, Zolfaghari-Nia A, Foley AJR, Fent GJ, Chew PG, Brown LA, Saunderson CE, Dall'Armellina E, Greenwood JP, Plein S. Regression of Left Ventricular Mass in Athletes Undergoing Complete Detraining Is Mediated by Decrease in Intracellular but Not Extracellular Compartments.Circ Cardiovasc Imaging. 2019 Sep;12(9):e009417. doi: 10.1161/CIRCIMAGING.119.009417. Epub 2019 Sep 11.

Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE, Ainscough JF, Pinteaux E, Drinkhill MJ, Turner NA. Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction. JCI Insight. 2019 Aug 8;5. pii: 125074. doi: 10.1172/jci.insight.125074.

Mortimer I, Bissell LA, Hensor EMA, Kozera L, Mackie SL, Burska AN, Nam JL, Keen H, Villeneuve E, Donica H, Buch MH, Conaghan PG, Emery P, Morgan AW, Andrews J. Improvement in cardiovascular biomarkers sustained at 4 years following an initial treat-to-target strategy in early rheumatoid arthritis.Rheumatology (Oxford). 2019 Sep 1;58(9):1684-1686. doi: 10.1093/rheumatology/kez114. No abstract available

Nagel E, Greenwood JP, McCann GP, Bettencourt N, Shah AM, Hussain ST, Perera D, Plein S, Bucciarelli-Ducci C, Paul M, Westwood MA, Marber M, et al for the MR-INFORM Investigators*.  Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease (2019) N Engl J Med. DOI: 10.1056/NEJMoa1716734

Miteva KT, Pedicini L, Wilson LA, Jayasinghe I, Slip RG, Marszalek K, Gaunt HJ, Bartoli F, Deivasigamani S, Sobradillo D, Beech DJ, McKeown L. Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies. J Cell Biol. (2019) May 15. pii: jcb.201810118. doi: 10.1083/jcb.201810118. [Epub ahead of print]

Musa TA, Treibel TA, Vassiliou VS, Captur G, Singh A, Chin C, Dobson LE, Pica S, Loudon M, Malley T, Rigolli M, Foley JRJ, Bijsterveld P, Law GR, Dweck M, Myerson SG, McCann GP, Prasad SK, Moon JC, Greenwood JP. Myocardial Scar and Mortality in Severe Aortic Stenosis: Data from the BSCMR Valve Consortium. Circulation. 2018 Jul 12. pii: CIRCULATIONAHA.117.032839. doi: 10.1161/CIRCULATIONAHA.117.032839.

Macrae FL, Duval C, Papareddy P, Baker SR, Yuldasheva N, Kearney KJ, McPherson HR, Asquith N, Konings J, Casini A, Degen JL, Connell SD, Philippou H, Wolberg AS, Herwald H, Ariëns RAS (2018) A fibrin biofilm covers the blood clot and protects from microbial invasion. J Clin Invest. DOI: 10.1172

Hall M, Dondo TB, Yan AT, Mamas MA, Timmis AD, Deanfield JE, Jernberg T, Hemingway H, Fox KAA, Gale CP (2018) Multi-morbidity and survival for AMI patients, 2003-2013: Latent class analysis of a nationwide population based cohortPLOS Medicine DOI: 10.1371

Witte KK, Drozd M, Walker AMN, Patel PA, Kearney JC, Chapman S, Sapsford RJ, Gierula J, Paton MF, Lowry J, Kearney MT, Cubbon RM. (2017) Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes. Diabetes Care DOI: 10.2337/dc17-1406.

Bentham JR, Zava NK, Harrison WJ, Shauq A, Kalantre A, Derrick G, Chen RH, Dhillon R, Taliotis D, Kang SL, Crossland D, Adesokan A, Hermuzi A, Kudumula V, Yong S, Noonan P, Hayes N, Stumper O, Thomson JDR. (2017) Duct Stenting versus Modified Blalock Taussig Shunt in Neonates with Duct-Dependent Pulmonary Blood Flow: Associations with Clinical Outcomes in a Multicenter National Study. Circulation.  DOI: 10.1161

Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT & Beech DJ. (2017) Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nature Communications.  8(1):350. DOI: 10.1038/s41467-017-00429-3

Watt NT, Gage MC, Patel PA, Viswambharan H, Sukumar P, Galloway S, Yuldasheva NY, Imrie H, Walker AM, Griffin KJ, Makava N, Skromna A, Bridge K, Beech DJ, Schurmans S, Wheatcroft SB, Kearney MT, Cubbon RM. (2017) Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction and Systemic Insulin Resistance. Diabetes. 66(11):2808-2821. DOI: 10.2337/db17-0062

Abuarab N, Munsey TS, Jiang L-H, Li J, Sivaprasadarao A (2017) High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission. Sci. Signal. 10(490). DOI: 10.1126/scisignal.aal4161

Al-Owais MM, Hettiarachchi NT, Kirton HM, Hardy ME, Boyle JP, Scragg JL, Steele DS, Peers C. (2017)  A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide-induced proarrhythmic early afterdepolarizations.  FASEB J. 31(11):4845-4854. DOI 10.1096/fj.201700259R

Dondo TB, Hall M, West RM, Jernberg T, Lindahl B, Bueno H, Danchin N, Deanfield JE, Hemingway H, Fox KAA, Timmis AD, Gale CP (2017) β-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction. J Am Coll Cardiol. 6;69(22):2710-2720. DOI: 10.1016/j.jacc.2017.03.578

 

Beckers CML, Simpson KR, Griffin KJ, Brown JM, Cheah LT, Smith KA, Vacher J, Cordell PA, Kearney MT, Grant PJ, Pease RJ (2017) Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A. Arterioscler Thromb Vasc Biol. 37(8): 1494-1502. DOI: 10.1161/ATVBAHA.117.309271.

 

Huang H, Vandekeere S, Kalucka J, Bierhansl L, Zecchin A, Brüning U, Visnagri A, Yuldasheva N, Goveia J, Cruys B, Brepoels K, Wyns S, Rayport S, Ghesquière B, Vinckier S, Schoonjans L, Cubbon R, Dewerchin M, Eelen G, Carmeliet P (2017) Role of glutamine and interlinked asparagine metabolism in vessel formation. EMBO J. 36(16): 2334-2352.  DOI: 10.15252/embj.201695518.

Tiede C, Bedford R, Heseltine SJ, Smith G, Wijetunga I, Ross R, AlQallaf D, Roberts AP, Balls A, Curd A, Hughes RE, Martin H, Needham SR, Zanetti-Domingues LC, Sadigh Y, Peacock TP, Tang AA, Gibson N, Kyle H, Platt GW, Ingram N, Taylor T, Coletta LP, Manfield I, Knowles M, Bell S, Esteves F, Maqbool A, Prasad RK, Drinkhill M, Bon RS, Patel V, Goodchild SA, Martin-Fernandez M, Owens RJ, Nettleship JE, Webb ME, Harrison M, Lippiat JD, Ponnambalam S, Peckham M, Smith A, Ferrigno PK, Johnson M, McPherson MJ, Tomlinson DC (2017) Affimer proteins are versatile and renewable affinity reagents. Elife. DOI: 10.7554/eLife.24903

Bright CJ, Hawkins MM, Guha J, Henson KE, Winter DL, Kelly JS, Feltbower RG, Hall M, Cutter DJ, Edgar AB, Frobisher C, Reulen RC (2017) Risk of Cerebrovascular Events in 178,962 5-Year Survivors of Cancer Diagnosed Aged 15-39 Years: The Teenage and Young Adults Cancer Survivors Study (TYACSS) Circulation. 135(13): 1194-1210.  doi.org/10.1161/CIRCULATIONAHA.116.025778

Roberts LD, Ashmore T, McNally BD, Murfitt, SA, Fernandez BO, Feelisch M, Lindsay R, Siervo M, Williams EA, Murray AJ, Griffin JL (2017). Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-type Switching and Myokine and GABA Release. Diabetes. 66(3):674-688. DOI: 10.2337/db16-0843.

Haywood NJ, Cordell PA, Tang KY, Makova N, Yuldasheva NY, Imrie H, Viswambharan H, Bruns AF, Cubbon RM, Kearney MT, Wheatcroft SB (2017). Insulin-like growth factor binding protein 1 could improve glucose regulation and insulin sensitivity through its RGD domain. Diabetes. 66:1-13.

Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood NJ, Walker AM, Skromna A, Makova N, Galloway SL, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft S, Cubbon RM, Kearney MT (2016). Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signalling Loop. Circ Res. 199(12).

Greenwood, J.P., Herzog, B.A., Brown, J.M., Everett, C.C., Nixon, J., Bijsterveld, P., Maredia, N., Motwani, M., Dickinson, C.J., Ball, S.G., Plein, S. (2016). Prognostic Value of Cardiovascular Magnetic Resonance and Single-Photon Emission Computed Tomography in Suspected Coronary Heart Disease: Long-Term Follow-up of a Prospective, Diagnostic Accuracy Cohort Study. Ann Intern Med. 165(1):1-9.

Jamil, H.A., Gierula, J., Paton, M.F., Byrom, R., Lowry, J.E., Cubbon, R.M., Cairns, D.A., Kearney, M.T., Witte, K.K. (2016). Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure. J Am Coll Cardiol. 67, 1885-96.

Witte, K.K., Byrom, R., Gierula, J., Paton, M.F., Jamil, H.A., Lowry, J.E., Gillott, R.G., Barnes, S.A., Chumun, H., Kearney, L.C., Greenwood, J.P., Plein, S., Law, G.R., Pavitt, S., Barth, J.H., Cubbon, R.M., Kearney, M.T. (2016). Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study. J Am Coll Cardiol. 67(22), 2593-603.

Mouapi, K.N., Bell, J.D., Smith, K.A., Ariëns, R.A., Philippou, H., Maurer, M.C. (2016). Ranking reactive glutamines in the fibrinogen αC region that are targeted by blood coagulant Factor XIII. Blood. 127(18), 2241-8.

Duval, C., Ali, M., Chaudhry, W.W., Ridger, V.C., Ariëns, R.A., Philippou, H. (2016). Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis. Arterioscler Thromb Vasc Biol. 36, 308-16

Domingues, M.M., Macrae, F.L., Duval, C., McPherson, H.R., Bridge, K.I., Ajjan, R.A., Ridger, V.C., Connell, S.D., Philippou, H. and Ariëns, R.A.S. (2016). Thrombin and fibrinogen gamma’ impact clot structure by marked effects on intrafibrillar structure and protofibril packing. Blood. 127, 487-95 .

Yang, Z., Kirton, H.M., MacDougall, D.A., Boyle, J.P., Deuchars, J., Frater, B., Ponnambalam, S., Hardy, M.E., White, E., Calaghan, S.C., Peers, C., Steele, D.S. (2015). The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway. Sci Signal 13.

Abraham, S., Scarcia, M., Bagshaw, R.D., McMahon, K., Grant, G., Harvey, T., Yeo, M., Esteves, F.O., Thygesen, H.H., Jones, P.F., Speirs, V., Hanby, A.M., Selby, P.J., Lorger, M., Dear, T.N., Pawson, T., Marshall, C.J., Mavria, G. (2015). A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Nature Communications. 6, 7286.

Li, J., Bruns, A., Hou, B., Rode, B., Webster, P.J., Bailey, M.A., Appleby, H.L., Moss, N.K., Ritchie, J.E., Yuldasheva, N., Tumova, S., Quinney, M., McKeown, L., Taylor, H., Prasad, K.R., Burke, D., O’Regan, D., Porter, K.E., Foster, R., Kearney, M.T., Beech, D.J. (2015). Orai3 surface accumulation and calcium entry evoked by vascular endothelial growth factor. Arteriosclerosis, Thrombosis and Vascular Biology. 35(9), 1987-94.

Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A., Ludlow, M.J., Sedo, A., Hyman, A.J., McKeown, L., Young, R.S., Yuldasheva, N.Y., Majeed, Y., Wilson, L.A., Rode, B., Bailey, M.A., Kim, H.R., Fu, Z., Carter, D.A.L., Bilton, J., Imrie, H., Ajuh, P., Dear, T.N., Cubbon, R.M., Kearney, M.T., Prasad, R.K., Evans, P.C., Ainscough, J.F.X., Beech, D.J. (2014). Piezo1 integration of vascular architecture with physiological force. Nature. 515, 279-82.

Cubbon, R.M., Yuldasheva, N.Y., Viswambharan, H., Mercer, B.N., Baliga, V., Stephen, S.L., Askham, J., Sukumar, P., Skromna, A., Mughal, R.S., Walker, A.M., Bruns, A., Bailey, M.A., Galloway, S., Imrie, H., Gage, M.C., Rakobowchuk, M., Li, J., Porter, K.E., Ponnambalam, S., Wheatcroft, S.B., Beech, D.J., Kearney, M.T. (2014). Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential. Stem Cells. 32, 2714-23.

Fearnley, G.W., Odell, A.F., Latham, A.M., Mughal, N.A., Bruns, A.F., Burgoyne, N.J., Homer-Vanniasinkam, S., Zachary, I.C., Hollstein, M.C., Wheatcroft, S.B., Ponnambalam, S. (2014). VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions. Molecular Biology of the Cell. 25, 2509-21.

Yuldasheva, N.Y., Rashid, S.T., Haywood, N.J., Cordell, P., Mughal, R., Viswambharan, H., Imrie, H., Sukumar, P., Cubbon, R.M., Aziz, A., Gage, M., Mbonye, K.A., Smith, J., Galloway, S., Skromna, A., Scott, D.J., Kearney, M.T., Wheatcroft, S.B. (2014). Haploinsufficiency of the Insulin-Like Growth Factor-1 Receptor Enhances Endothelial Repair and Favorably Modifies Angiogenic Progenitor Cell Phenotype. Arterioscler Thromb Vasc Bio. 34, 2051-8.

Lolicato, M., Bucchi, A., Arrigoni, C., Zucca, S., Nardini, M., Schroeder, I., Simmons, K., Aquila, M., DiFrancesco, D., Bolognesi, M., Schwede, F., Kashin, D., Fishwick, C.W., Johnson, A.P., Thiel, G., Moroni, A. (2014). Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat Chem Biol. 10, 457-462.

Greenwood JP, Motwani M, Maredia N, Brown JM, Everett CC, Nixon J, Bijsterveld P, Dickinson CJ, Ball SG, Plein S. (2014). Comparison of cardiovascular magnetic resonance and single-photon emission computed tomography in women with suspected coronary artery disease from the Clinical Evaluation of Magnetic Resonance Imaging in Coronary Heart Disease (CE-MARC) Trial. Circulation. 129:1129-1138.

Elies J, Dallas ML, Boyle JP, Scragg JL, Duke A, Steele DS, Peers C. (2014). Inhibition of the cardiac Na+ channel Nav1.5 by carbon monoxide. J Biol Chem. 289, 16421-16429.

 

 

Example reviews

Kietsiriroje N, Pearson S, Campbell M, Ariëns RAS, Ajjan RA. Double diabetes: A distinct high-risk group? Diabetes Obes Metab. 2019 Aug 2. doi: 10.1111/dom.13848. [Epub ahead of print] Review.

Turner NA, Blythe NM. Cardiac Fibroblast p38 MAPK: A Critical Regulator of Myocardial Remodeling. J Cardiovasc Dev Dis. 2019 Aug 7;6(3). pii: E27. doi: 10.3390/jcdd6030027. Review.

Beech DJ, Kalli AC. Force Sensing by Piezo Channels in Cardiovascular Health and Disease. Arterioscler Thromb Vasc Biol. 2019 Sep 19:ATVBAHA119313348. doi: 10.1161/ATVBAHA.119.313348. [Epub ahead of print]

Turner, N.A. (2018). Strength in Numbers - Cardiac Fibroblast Clustering and Myocardial Remodeling. Circ. Res. 123:12-14.

King, R.J., Ajjan, R.A. (2017) Vascular risk in obesity: Facts, misconceptions and the unknown.  Diab Vasc Dis Res. 14, 2-13

Garg, P., Underwood, S.R., Senior, R., Greenwood, J.P., Plein, S. (2016). Noninvasive cardiac imaging in suspec-ted acute coronary syndrome. Nat Rev Cardiol. 13, 266-75

Cubbon, R.M., Kearney, M.T., Wheatcroft, S.B. (2016). Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance. Trends Endocrinol Metab. 27, 96-104

Zani, I.A., Stephen, S.L., Mughal, N.A., Russell, D., Homer-Vanniasinkam, S., Wheatcroft, S.B., Ponnambalam, S. (2015). Scavenger receptor structure and function in health and disease. Cells. S 4, 178-201.

Peers, C., Boyle, J.P., Scragg, J.L., Dallas, M.L., Al-Owais, M.M., Hettiarachichi, N.T., Elies, J., Johnson, E., Gamper, N., Steele, D.S. (2015). Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. Br J Pharmacol. 172, 1546-1556.

Motwani, M., Kidambi, A., Greenwood, J.P., Plein, S. (2014). Advances in cardiovascular magnetic resonance in ischaemic heart disease and non-ischaemic cardiomyopathies. Heart. 100, 1722-1733.

Zhaokang, Y., Kirton, HM., Al-Owais, M,. Jerome, T., Sylvain, R., Peers, CS., Steele, D.S. (2017) Epac2-Rap1 signalling regulates reactive oxygen species production and susceptibility to cardiac arrhythmias. Antioxid Redox Signal. DOI: 10.1089/ars.2015.6485

What's Happening

16 October 2019: DTSD Seminar: 'Role of Tenascin C in Cardiovascular Disease' and Understanding small molecule activation and inhibition of TRPC1/4/5 channels. ... more

23 October 2019: DTSD Seminar ... more

25 October 2019: SBMS Seminar: Co-regulation of TRPC4 by phospholipase C and Gi/o proteins and its physiological implication ... more

Athena Swan