Multidisciplinary Cardiovascular Research Centre
Cardiovascular discovery and therapeutics
David J Beech: Research Lab
Research publications
The list below shows example original research publications out of a total of 107. A list of all publications can be found at http://www.ncbi.nlm.nih.gov/sites/entrez by using “beech dj” as the search enquiry (+ “leeds” to narrow the search post-1993).
Li, J., Cubbon, R.M., Wilson, L.A., Amer, M.S., McKeown, L., Hou, B., Majeed, Y., Tumova, S., Seymour, V.A.L., Taylor, H., Stacey, M., O’Regan, D., Foster, R., Porter, K.E., Kearney, M.T., Beech, D.J. (2011). Orai1 and CRAC channel dependence of VEGF-activated Calcium-entry and endothelial tube formation. Circulation Research 108, 1190-1198.
Naylor, J., AL-Shawaf, E., McKeown, L., Manna, P.T., Porter, K.E., O’Regan, D., Muraki, K., Beech, D.J. (2011). TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes. Journal of Biological Chemistry 286, 5078-5086.
Cheong, A., Li, J., Sukumar, P., Kumar, B., Zeng, F., Riches, K., Munsch, C., Wood, I.C., Porter, K.E., Beech, D.J. (2011). Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by Kv1.3 channel blockers. Cardiovascular Research 89, 282-289.
AL-Shawaf, E., Naylor, J., Taylor, H., Riches, K., Milligan, C.J., O’Regan, D., Porter, K.E., Li, J., Beech, D.J. (2010). Stimulation of calcium-permeable TRPC5-containing channels by oxidized phospholipids. Arterioscler Thromb Vasc Biol. 30, 1453-1459.
Naylor, J., Li, J., Milligan, C.J., Zeng, F., Sukumar, P., Hou, B., Sedo, A., Yuldasheva, N., Majeed, Y., Beri, D., Jiang, S., Seymour, V.A.L., McKeown, L., Kumar, B., Harteneck, C., O’Regan, D., Wheatcroft, S.B., Kearney, M.T., Jones, C., Porter, K.E., Beech, D.J. (2010). Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. Circulation Research 106, 1507-1515.
Milligan, C.J., Li, J., Sukumar, P., Majeed, Y., Dallas, M.L., English, A., Emery, P., Porter, K.E., Smith, A.M., McFadzean, I., Beccano-Kelly, D., Bahnasi, Y., Cheong, A., Naylor, J., Zeng, F., Liu, X., Gamper, N., Jiang, L.-H., Pearson, H.A., Peers, C., Robertson, B., Beech, D.J. (2009). Robotic multi-well planar patch-clamp for native and primary mammalian cells. Nature Protocols 4, 244-255.
Li, J., Sukumar, P., Milligan, C.J., Kumar, B., Ma, Z., Munsch, C.M., Jiang, L.H., Porter, K.E., Beech, D.J. (2008). Interactions, functions and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circulation Research 103, e97-104.
Xu, S.Z., Sukumar, P., Zeng, F., Li, J., Jairaman, A., English, A., Naylor, J., Ciurtin, C., Majeed, Y., Milligan, C.J., Bahnasi, Y.M., AL-Shawaf, E., Porter, K.E., Jiang, L.H., Emery, P., Sivaprasadarao, A. & Beech, D.J. (2008). TRPC channel activation by extracellular thioredoxin. Nature 451, 69-72.
Xu, S.Z., Muraki, K., Zeng, F., Li, J., Sukumar, P., Shah, S.S., Dedman, A.M., Flemming, P.K., McHugh, D., Naylor, J., Cheong, A., Bateson, A.N., Munsch, C.M., Porter, K.E. & Beech, D.J. (2006). A sphingosine-1-phosphate activated calcium channel controlling vascular smooth muscle cell motility. Circulation Research 98, 1381-1389.
Kumar, B., Dreja, K., Shah, S., Cheong, C., Xu, S., Sukumar, P., Naylor, J., Forta, A., Cipollaro, M., McHugh, D., Kingston, P.A., Heagerty, A.M., Munsch, C.M., Bergdahl, A., Hultgårdh-Nilsson, A., Gomez, M.F., Porter, K.E., Hellstrand, P. & Beech, D.J. (2006). Up-regulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia. Circulation Research 98, 557-563.
Flemming, P.K., Dedman, A.M., Xu, S.Z., Li, J., Zeng, F., Naylor, J., Benham, C.D., Bateson, A.N. & Beech, D.J. (2006). Sensing of lysophospholipids by TRPC5 calcium channel. Journal of Biological Chemistry 281, 4977-4982.
Xu, S., Zeng, F., Lei, M., Li, J., Gao, B., Xiong, C., Sivaprasadarao, A. & Beech, D.J. (2005). Generation of functional ion channel tools by E3-targeting. Nature Biotechnology 23, 1289-1293.
Cheong, A., Bingham, A.J., Li, J., Kumar, B., Sukumar, P., Munsch, C., Buckley, N.J., Neylon, C.B., Porter, K.E., Beech, D.J. & Wood, I.C. (2005). Down-regulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation. Molecular Cell 20, 45-52.
McHugh, D., Flemming, R., Xu, S.Z., Perraud, A.L. & Beech, D.J. (2003). Critical intracellular Ca2+-dependence of Transient Receptor Potential Melastatin 2 (TRPM2) cation channel activation. Journal of Biological Chemistry 278, 11002-11006.
Flemming, R., Cheong, A., Dedman, A.M. and Beech, D.J. (2002). Discrete store-operated calcium influx into an intracellular compartment in rabbit arteriolar smooth muscle. Journal of Physiology 543, 455-464.
Xu, S.Z. and Beech, D.J. (2001). TrpC1 is a membrane-spanning subunit of store-operated Ca2+ channels in native vascular smooth muscle cells. Circulation Research 88, 84-87.