Multidisciplinary Cardiovascular Research Centre

Richard Cubbon

Clinical Lecturer in Cardiology

Cardiovascular and Diabetes Research

Qualifications: MBChB, MRCP, PhD

Email: R.Cubbon@leeds.ac.uk

Telephone: 0113 343 7230

Research Area

The impact of insulin resistance on vascular function and repair

Details

The broad focus of my work is in assessing the impact of insulin resistance and diabetes mellitus on vascular endothelial dysfunction, predominantly from the perspective of dysregulated endogenous vascular repair mechanisms, such as progenitor cells. This is addressed using in vitro and in vivo studies in the setting of human and murine insulin resistance. It is hoped this work will result in cellular or pharmacological therapies to retard or regress vascular disease in diabetes and prediabetes, and so reduce major cardiovascular events.
My other research interests include the derivation and application of prognostic models in chronic heart failure, and also of assessing the impact of diabetes and pre-diabetes on cardiovascular outcomes.

Recent Projects

British Heart Foundation. PhD Studentship (FS\08\059\25362). £162526 commencing August 2009. Investigating the effects of insulin resistance on endothelial progenitor cells and vascular repair. Wheatcroft SB, Cubbon RM, Kearney MT.
 
British Heart Foundation Project Grant (PG/08/060/25340) £136,262 over 3 years commencing January 2009. Can a moderate intensity exercise programme improve endothelial function in post-menopausal women with type 2 diabetes? Birch KM, Kearney MT, Cubbon RM
 
British Heart Foundation. PhD Studentship for Dr. Richard Cubbon (FS/06/036) £140,274  over 3 years commencing February 2006. Do young Asian men have impaired endothelial function secondary to reduced endothelial progenitor cell mobilisation in response to exercise? Kearney MT, Porter KE, Ward SE, Hill JA.

Publications

Recent

Rajwani A; Ezzat V; Smith J; Yuldasheva NY; Duncan ER; Gage M; Cubbon RM; Kahn MB; Imrie H; Abbas A; Viswambharan H; Aziz A; Sukumar P; Vidal-Puig A; Sethi JK; Xuan S; Shah AM; Grant PJ; Porter KE; Kearney MT; Wheatcroft SB (2012) Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis. DIABETES, 61 , pp. 915-924.

Rakobowchuk M; Harris E; Taylor A; Baliga V; Cubbon RM; Rossiter HB; Birch KM (2012) Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans. EXPERIMENTAL PHYSIOLOGY, 97 , pp. 375-385.

Selected

Cubbon RM; Gale CP; Kearney LC; Schechter CB; Brooksby WP; Nolan J; Fox KAA; Rajwani A; Baig W; Groves D; Barlow P; Fisher AC; Batin PD; Kahn MB; Zaman AG; Shah AM; Byrne JA; Lindsay SJ; Sapsford RJ; Wheatcroft SB; Witte KK; Kearney MT (2011) Changing Characteristics and Mode of Death Associated With Chronic Heart Failure Caused by Left Ventricular Systolic Dysfunction A Study Across Therapeutic Eras. CIRCULATION-HEART FAILURE, 4 .

Li J; Cubbon RM; Wilson LA; Amer MS; McKeown L; Hou B; Majeed Y; Tumova S; Seymour VAL; Taylor H; Stacey M; O'Regan D; Foster R; Porter KE; Kearney MT; Beech DJ (2011) Orai1 and CRAC Channel Dependence of VEGF-Activated Ca2+ Entry and Endothelial Tube Formation. CIRCULATION RESEARCH, 108 , pp. 1190-U131.

Kahn MB; Yuldasheva NY; Cubbon RM; Smith J; Rashid ST; Viswambharan H; Imrie H; Abbas A; Rajwani A; Aziz A; Baliga V; Sukumar P; Gage M; Kearney MT; Wheatcroft SB (2011) Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration. DIABETES, 60 , pp. 1295-1303.

Cubbon RM; Murgatroyd SR; Ferguson C; Bowen TS; Rakobowchuk M; Baliga V; Cannon D; Rajwani A; Abbas A; Kahn M; Birch KM; Porter KE; Wheatcroft SB; Rossiter HB; Kearney MT (2010) Human Exercise-Induced Circulating Progenitor Cell Mobilization Is Nitric Oxide-Dependent and Is Blunted in South Asian Men. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30 , pp. 878-U626.

All

Rajwani A; Ezzat V; Smith J; Yuldasheva NY; Duncan ER; Gage M; Cubbon RM; Kahn MB; Imrie H; Abbas A; Viswambharan H; Aziz A; Sukumar P; Vidal-Puig A; Sethi JK; Xuan S; Shah AM; Grant PJ; Porter KE; Kearney MT; Wheatcroft SB (2012) Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis. DIABETES, 61 , pp. 915-924.

Rakobowchuk M; Harris E; Taylor A; Baliga V; Cubbon RM; Rossiter HB; Birch KM (2012) Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans. EXPERIMENTAL PHYSIOLOGY, 97 , pp. 375-385.

Cubbon RM; Ali N; Sengupta A; Kearney MT (2012) Insulin- and growth factor-resistance impairs vascular regeneration in diabetes mellitus. Current Vascular Pharmacology, 10 (3), pp. 271-284.

Rakobowchuk M; Harris E; Taylor A; Baliga V; Cubbon RM; Rossiter HB; Birch KM (2012) Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans. Experimental Physiology, 97 (3), pp. 375-385.

Meta-analysis Global Group in Chronic Heart Failure (MAGGIC) (2011) The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis.. Eur Heart J, .

Abbas A; Imrie H; Viswambharan H; Sukumar P; Rajwani A; Cubbon RM; Gage M; Smith J; Galloway S; Yuldeshava N; Kahn M; Xuan S; Grant PJ; Channon KM; Beech DJ; Wheatcroft SB; Kearney MT (2011) The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium. DIABETES, 60 , pp. 2169-2178.

Cubbon RM; Gale CP; Kearney LC; Schechter CB; Brooksby WP; Nolan J; Fox KAA; Rajwani A; Baig W; Groves D; Barlow P; Fisher AC; Batin PD; Kahn MB; Zaman AG; Shah AM; Byrne JA; Lindsay SJ; Sapsford RJ; Wheatcroft SB; Witte KK; Kearney MT (2011) Changing Characteristics and Mode of Death Associated With Chronic Heart Failure Caused by Left Ventricular Systolic Dysfunction A Study Across Therapeutic Eras. CIRCULATION-HEART FAILURE, 4 .

Li J; Cubbon RM; Wilson LA; Amer MS; McKeown L; Hou B; Majeed Y; Tumova S; Seymour VAL; Taylor H; Stacey M; O'Regan D; Foster R; Porter KE; Kearney MT; Beech DJ (2011) Orai1 and CRAC Channel Dependence of VEGF-Activated Ca2+ Entry and Endothelial Tube Formation. CIRCULATION RESEARCH, 108 , pp. 1190-U131.

Kahn MB; Yuldasheva NY; Cubbon RM; Smith J; Rashid ST; Viswambharan H; Imrie H; Abbas A; Rajwani A; Aziz A; Baliga V; Sukumar P; Gage M; Kearney MT; Wheatcroft SB (2011) Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration. DIABETES, 60 , pp. 1295-1303.

Kahn M; Cubbon R; Mercer B; Gherardi G; Wheatcroft A; Somers K; Liu A; Blaxill J; McLenachan J; Sivananthan M; Blackman D; Greenwood J; Wheatcroft S (2010) Impact Of Diabetes on Survival after Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction. CIRCULATION, 122 .

Cubbon RM; Murgatroyd SR; Ferguson C; Bowen TS; Rakobowchuk M; Baliga V; Cannon D; Rajwani A; Abbas A; Kahn M; Birch KM; Porter KE; Wheatcroft SB; Rossiter HB; Kearney MT (2010) Human Exercise-Induced Circulating Progenitor Cell Mobilization Is Nitric Oxide-Dependent and Is Blunted in South Asian Men. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30 , pp. 878-U626.

Imrie H; Abbas A; Viswambharan H; Rajwani A; Cubbon RM; Gage M; Kahn M; Ezzat VA; Duncan ER; Grant PJ; Ajjan R; Wheatcroft SB; Kearney MT (2009) Vascular Insulin-Like Growth Factor-I Resistance and Diet-Induced Obesity. ENDOCRINOLOGY, 150 , pp. 4575-4582.

Cubbon RM; Kahn MB; Wheatcroft SB (2009) Effects of insulin resistance on endothelial progenitor cells and vascular repair. CLINICAL SCIENCE, 117 , pp. 173-190.

Cubbon RM; Witte KKA (2009) Cardiac resynchronisation therapy for chronic heart failure and conduction delay. BRITISH MEDICAL JOURNAL, 338 .

Cubbon RM; Witte KKA (2009) Cardiac resynchronisation therapy for chronic heart failure. BMJ (Online), 338 (7702), pp. 1064-1069.

Cubbon RM; Abbas A; Wheatcroft SB; Kilcullen N; Das R; Morrell C; Barth JH; Kearney MT; Hall AS; Investigators EMMACE2 (2008) Diabetes Mellitus and Mortality after Acute Coronary Syndrome as a First or Recurrent Cardiovascular Event. PLOS ONE, 3 .

Cubbon RM; Gale CP; Rajwani A; Abbas A; Morrell C; Das R; Barth JH; Grant PJ; Kearney MT; Hall AS (2008) Aspirin and Mortality in Patients With Diabetes Sustaining Acute Coronary Syndrome. DIABETES CARE, 31 , pp. 363-365.

Cubbon R; Kahn M; Kearney MT (2008) Secondary prevention of cardiovascular disease in type 2 diabetes and prediabetes: a cardiologist's perspective. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 62 , pp. 287-299.

Cubbon RM; Kahn M; Rajwani A; Gale CP; Kearney MT (2008) Echocardiography in the investigation of cardiomyopathy. Ultrasound, 16 (2), pp. 73-79.

Cubbon RM; Gale CP; Grant PJ; Hall AS; Kearney MT (2007) Lower rates of heart failure and death in acute coronary syndromes. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 298 , pp. 969-969.

Cubbon RM; Kearney MT (2007) Acute metabolic derangement and the heart. British Journal of Diabetes and Vascular Disease, 7 (5), pp. 218-222.

Cubbon RM; Rajwani A; Wheatcroft SB (2007) The impact of insulin resistance on endothelial function, progenitor cells and repair. Diabetes and Vascular Disease Research, 4 (2), pp. 103-111.

Cubbon RM; Rajwani A; Abbas A; Gale CP; Hall AS; Kearney MT (2007) Mortality of patients with diabetes mellitus and acute myocardial infarction. Cardiology Review, 24 (10), pp. 22-26.

Adlam D; Cubbon RM; Skehan D (2004) Implantation of an epicardial dual chamber ICD following unsuccessful percutaneous extraction of a failed ventricular shocking electrode. PACE - Pacing and Clinical Electrophysiology, 27 (5), pp. 686-687.

Teaching Commitments

Regular bed-side and lecture based teaching of 2nd, 3rd and 5th year medical undergraduates undertaking MBChB.