Multidisciplinary Cardiovascular Research Centre

Karen E Porter

Reader in Cardiovascular Cell Biology

Cardiovascular and Neuronal Remodelling

Qualifications: BSc (Hons), Leeds; PhD, Leicester

Email: K.E.Porter@leeds.ac.uk

Telephone: 0113 343 4806

Karen E Porter

Research Area

Investigating aberrant cellular phenotype and function in cardiovascular remodelling and diabetes

Details

One of the key strengths of my research is the capacity to cultivate and study the phenotype and function of cardiovascular cells directly from human tissue. In collaboration with David O'Regan (consultant cardiothoracic surgeon, LGI) we are able to study vascular smooth muscle,  endothelial cells and cardiac fibroblasts from different patients, up to 25% of whom have diabetes. Diabetes is an escalating problem worldwide; importantly individuals with diabetes are at significantly higher risk of cardiovascular disease than the non-diabetic population. Even when blood glucose levels are effectively controlled by drug therapies, diabetic patients still suffer cardiovascular complications such as atherosclerosis and restenosis, suggesting that factors other than hyperglycaemia are involved. Our present studies aim to elucidate the cellular and molecular mechanisms that contribute to increased cardiovascular risk in individuals with type 2 diabetes (T2DM) and understand their significantly poorer outcomes after vascular interventions. This is facilitated by our ability to compare in a side-by-side manner, vascular tissues and their component cells (endothelium, smooth muscle) from patients with and without diabetes. Our preliminary evidence points to malfunction of  key signalling pathways and altered molecular pathways caused by the underlying metabolic abnormalities of T2DM and not the elevation of glucose itself.  Establishing the underlying mechanisms has significant potential to translate into a completely new area of early therapy for patients before diagnosis of overt T2DM.
 

Recent Projects

Enhancing vascular endothelial repair in the setting of insulin resistance: the role of insulin-like growth factor binding protein-1 (BHF Clinical Research Training Fellowship FS/11/44)
A Aziz, S Wheatcroft, KE Porter & N Yuldasheva      
(2011-14)    £191,241
 
Functions and therapeutic potential of vascular Orai/CRAC channels (MRC MICA award G1002076)
DJ Beech, KE Porter, MT Kearney, JF-X Ainscough, IC Wood, D Jayne, M Main
(2011-14)    £723,000

 
Exploring the morphology and function of smooth muscle cells derived from abdominal aortic aneurysms (Royal College of Surgeons Intercalated BSc scholarship)
KE Porter
(2010-2011)      £4,500

 
Oxidized phospholipid ionic transduction mechanism of human vascular cells (MRC project  grant G0901761)
DJ Beech, A Sivaprasadarao, KE Porter, MT Kearney, M Stacey
(2010 – 2013)     £584,000
 
The vascular smooth muscle T-type Ca channel: an anti-proliferative target for heme  oxygenase-1 (BHF PhD studentship FS/10/010/28169)
C Peers, KE Porter & JL Scragg
(2010-2013)    £96, 591

 
The Rho/Rho kinase pathway as a mediator of aberrant vascular smooth muscle cell function  in patients with diabetes (BHRC Problem-Solving Fund) 
KE Porter, IC Wood, DJ O’Regan, NA Turner.
(2010-2011)    £10,450
 
Statins directly affect cardiac myocyte function through cholesterol-dependent and  independent mechanisms  (BHF Project Grant PG/09/051)
SC Calaghan & KE Porter.
(2009-2012)    £186,063


Publications

Recent

Turner, NA; Porter, KE (2012) Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts.. IUBMB Life, 64 (2), pp. 143-150.

Majeed, Y; Tumova, S; Green, BL; Seymour, VA; Woods, DM; Agarwal, AK; Naylor, J; Jiang, S; Picton, HM; Porter, KE; O'Regan, DJ; Muraki, K; Fishwick, CW; Beech, DJ (2012) Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone.. Cell Calcium, 51 (1), pp. 1-11.

Selected

Porter, KE; Turner, NA (2011) Statins and myocardial remodelling: cell and molecular pathways.. Expert Rev Mol Med, 13 , pp. e22.

Mughal, RS; Scragg, JL; Lister, P; Warburton, P; Riches, K; O'Regan, DJ; Ball, SG; Turner, NA; Porter, KE (2010) Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein.. Diabetologia, 53 (8), pp. 1761-1771.

Naylor, J; Li, J; Milligan, CJ; Zeng, F; Sukumar, P; Hou, B; Sedo, A; Yuldasheva, N; Majeed, Y; Beri, D; Jiang, S; Seymour, VA; McKeown, L; Kumar, B; Harteneck, C; O'Regan, D; Wheatcroft, SB; Kearney, MT; Jones, C; Porter, KE; Beech, DJ (2010) Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.. Circ Res, 106 (9), pp. 1507-1515.

Madi, HA; Riches, K; Warburton, P; O'Regan, DJ; Turner, NA; Porter, KE (2009) Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patients.. Am J Physiol Cell Physiol, 297 (5), pp. C1307-C1317.

Porter, KE; Turner, NA (2009) Cardiac fibroblasts: at the heart of myocardial remodeling.. Pharmacol Ther, 123 (2), pp. 255-278.

All

Turner, NA; Porter, KE (2012) Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts.. IUBMB Life, 64 (2), pp. 143-150.

Majeed, Y; Tumova, S; Green, BL; Seymour, VA; Woods, DM; Agarwal, AK; Naylor, J; Jiang, S; Picton, HM; Porter, KE; O'Regan, DJ; Muraki, K; Fishwick, CW; Beech, DJ (2012) Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone.. Cell Calcium, 51 (1), pp. 1-11.

Turner, NA; Das, A; O'Regan, DJ; Ball, SG; Porter, KE (2011) Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulation.. Int J Biochem Cell Biol, 43 (10), pp. 1450-1458.

Li, J; McKeown, L; Ojelabi, O; Stacey, M; Foster, R; O'Regan, D; Porter, KE; Beech, DJ (2011) Nanomolar potency and selectivity of a Ca²⁺ release-activated Ca²⁺ channel inhibitor against store-operated Ca²⁺ entry and migration of vascular smooth muscle cells.. Br J Pharmacol, 164 (2), pp. 382-393.

Li, J; Cubbon, RM; Wilson, LA; Amer, MS; McKeown, L; Hou, B; Majeed, Y; Tumova, S; Seymour, VA; Taylor, H; Stacey, M; O'Regan, D; Foster, R; Porter, KE; Kearney, MT; Beech, DJ (2011) Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.. Circ Res, 108 (10), pp. 1190-1198.

Maqbool, A; Keswani, A; Galloway, S; O'Regan, DJ; Ball, SG; Turner, NA; Porter, KE (2011) MMP-3 (5A/6A) Polymorphism Does Not Influence Human Smooth Muscle Cell Invasion.. J Surg Res, .

Majeed, Y; Amer, MS; Agarwal, AK; McKeown, L; Porter, KE; O'Regan, DJ; Naylor, J; Fishwick, CW; Muraki, K; Beech, DJ (2011) Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids.. Br J Pharmacol, 162 (7), pp. 1509-1520.

Naylor, J; Al-Shawaf, E; McKeown, L; Manna, PT; Porter, KE; O'Regan, D; Muraki, K; Beech, DJ (2011) TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes.. J Biol Chem, 286 (7), pp. 5078-5086.

Cheong, A; Li, J; Sukumar, P; Kumar, B; Zeng, F; Riches, K; Munsch, C; Wood, IC; Porter, KE; Beech, DJ (2011) Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers.. Cardiovasc Res, 89 (2), pp. 282-289.

Porter, KE; Turner, NA (2011) Statins and myocardial remodelling: cell and molecular pathways.. Expert Rev Mol Med, 13 , pp. e22.

Dedman, AM; Majeed, Y; Tumova, S; Zeng, F; Kumar, B; Munsch, C; Bateson, AN; Wittmann, J; Jäck, HM; Porter, KE; Beech, DJ (2011) TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells.. BMC Mol Biol, 12 , pp. 30.

Riches, K; Hettiarachchi, NT; Porter, KE; Peers, C (2010) Hypoxic remodelling of Ca2+ stores does not alter human cardiac myofibroblast invasion.. Biochem Biophys Res Commun, 403 (3-4), pp. 468-472.

Turner, NA; Warburton, P; O'Regan, DJ; Ball, SG; Porter, KE (2010) Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase.. Matrix Biol, 29 (7), pp. 613-620.

Mughal, RS; Scragg, JL; Lister, P; Warburton, P; Riches, K; O'Regan, DJ; Ball, SG; Turner, NA; Porter, KE (2010) Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein.. Diabetologia, 53 (8), pp. 1761-1771.

Al-Shawaf, E; Naylor, J; Taylor, H; Riches, K; Milligan, CJ; O'Regan, D; Porter, KE; Li, J; Beech, DJ (2010) Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids.. Arterioscler Thromb Vasc Biol, 30 (7), pp. 1453-1459.

Naylor, J; Li, J; Milligan, CJ; Zeng, F; Sukumar, P; Hou, B; Sedo, A; Yuldasheva, N; Majeed, Y; Beri, D; Jiang, S; Seymour, VA; McKeown, L; Kumar, B; Harteneck, C; O'Regan, D; Wheatcroft, SB; Kearney, MT; Jones, C; Porter, KE; Beech, DJ (2010) Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.. Circ Res, 106 (9), pp. 1507-1515.

Cubbon, RM; Murgatroyd, SR; Ferguson, C; Bowen, TS; Rakobowchuk, M; Baliga, V; Cannon, D; Rajwani, A; Abbas, A; Kahn, M; Birch, KM; Porter, KE; Wheatcroft, SB; Rossiter, HB; Kearney, MT (2010) Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.. Arterioscler Thromb Vasc Biol, 30 (4), pp. 878-884.

Bauer, CC; Boyle, JP; Porter, KE; Peers, C (2010) Modulation of Ca(2+) signalling in human vascular endothelial cells by hydrogen sulfide.. Atherosclerosis, 209 (2), pp. 374-380.

Shantikumar, S; Ajjan, R; Porter, KE; Scott, DJ (2010) Diabetes and the abdominal aortic aneurysm.. Eur J Vasc Endovasc Surg, 39 (2), pp. 200-207.

Maqbool, A; Turner, NA; Galloway, S; Riches, K; O'Regan, DJ; Porter, KE (2009) The -1562C/T MMP-9 promoter polymorphism does not predict MMP-9 expression levels or invasive capacity in saphenous vein smooth muscle cells cultured from different patients.. Atherosclerosis, 207 (2), pp. 458-465.

Madi, HA; Riches, K; Warburton, P; O'Regan, DJ; Turner, NA; Porter, KE (2009) Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patients.. Am J Physiol Cell Physiol, 297 (5), pp. C1307-C1317.

Riches, K; Morley, ME; Turner, NA; O'Regan, DJ; Ball, SG; Peers, C; Porter, KE (2009) Chronic hypoxia inhibits MMP-2 activation and cellular invasion in human cardiac myofibroblasts.. J Mol Cell Cardiol, 47 (3), pp. 391-399.

Turner, NA; Das, A; Warburton, P; O'Regan, DJ; Ball, SG; Porter, KE (2009) Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts.. Am J Physiol Heart Circ Physiol, 297 (3), pp. H1117-H1127.

Porter, KE; Turner, NA (2009) Cardiac fibroblasts: at the heart of myocardial remodeling.. Pharmacol Ther, 123 (2), pp. 255-278.

Mughal, RS; Warburton, P; O'Regan, DJ; Ball, SG; Turner, NA; Porter, KE (2009) PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR gamma-INDEPENDENT EFFECTS OF THIAZOLIDINEDIONES ON HUMAN CARDIAC MYOFIBROBLAST FUNCTION. CLIN EXP PHARMACOL P, 36 (5-6), pp. 478-486.

Amer, MS; Li, J; O'Regan, DJ; Steele, DS; Porter, KE; Sivaprasadarao, A; Beech, DJ (2009) Translocon closure to Ca2+ leak in proliferating vascular smooth muscle cells.. Am J Physiol Heart Circ Physiol, 296 (4), pp. H910-H916.

Aley, PK; Bauer, CC; Dallas, ML; Boyle, JP; Porter, KE; Peers, C (2009) Hypoxic modulation of ca(2+) signaling in human venous and arterial endothelial cells.. J Membr Biol, 227 (3), pp. 151-158.

Bahnasi, YM; O'Regan, DJ; Porter, KE; Beech, DJ (2009) FUNCTIONAL TRPC5-CONTAINING CHANNELS IN HUMAN SAPHENOUS VEIN ENDOTHELIAL CELLS. J PHYSIOL SCI, 59 , pp. 320-320.

Calaghan, SC; Porter, KE; Pugh, SD (2009) SIMVASTATIN HAS DIRECT EFFECTS ON CARDIAC MYOCYTE CAVEOLAE VIA DEPLETION OF MEMBRANE CHOLESTEROL. J PHYSIOL SCI, 59 , pp. 360-360.

Milligan, CJ; Li, J; Sukumar, P; Majeed, Y; Dallas, ML; English, A; Emery, P; Porter, KE; Smith, AM; McFadzean, I; Beccano-Kelly, D; Bahnasi, Y; Cheong, A; Naylor, J; Zeng, F; Liu, X; Gamper, N; Jiang, LH; Pearson, HA; Peers, C; Robertson, B; Beech, DJ (2009) Robotic multiwell planar patch-clamp for native and primary mammalian cells.. Nat Protoc, 4 (2), pp. 244-255.

Li, J; McKeown, L; Milligan, CJ; Naylor, J; O'Regan, D; Porter, KE; Beech, DJ (2009) NON-SELECTIVE CATIONIC CURRENT ASSOCIATED WITH ADAR1-EDITED HUMAN ORAI1. J PHYSIOL SCI, 59 , pp. 396-396.

Amer, MS; Li, J; Regan, DO; Porter, KE; Sivaprasadarao, A; Beech, DJ (2009) TRANSLOCON CLOSURE TO CALCIUM LEAK IN PROLIFERATING VASCULAR SMOOTH MUSCLE CELLS. J PHYSIOL SCI, 59 , pp. 239-239.

Aley, PK; Wilkinson, JA; Bauer, CC; Boyle, JP; Porter, KE; Peers, C (2008) Hypoxic remodelling of Ca2+ signalling in proliferating human arterial smooth muscle. MOL CELL BIOCHEM, 318 (1-2), pp. 101-108.

Li, J; Sukumar, P; Milligan, CJ; Kumar, B; Ma, ZY; Munsch, CM; Jiang, LH; Porter, KE; Beech, DJ (2008) Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells.. Circ Res, 103 (8), pp. e97-104.

Turner, NA; Warburton, P; Porter, KE (2008) IL10 selectively reduces expression of IL6, but not IL1 beta or TNF alpha, in human cardiac fibroblasts. HEART, 94 (9).

Mughal, RS; Turner, NA; Porter, KE (2008) Thiazolidinediones modulate human cardiac fibroblast function independently of PPAR gamma activation. HEART, 94 (9).

Patel, A; Jagadesham, VP; Porter, KE; Scott, DJA; Carding, SR (2008) Characterisation of fractalkine/CX3CL1 and fractalkine receptor (CX3CR1) expression in abdominal aortic aneurysm disease. EUR J VASC ENDOVASC, 36 (1), pp. 20-27.

Guy, JL; Lambert, DW; Turner, AJ; Porter, KE (2008) Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts. EXP PHYSIOL, 93 (5), pp. 579-588.

Eccles, KA; Sowden, H; Porter, KE; Parkin, SM; Homer-Vanniasinkam, S; Graham, AM (2008) Simvastatin alters human endothelial cell adhesion molecule expression and inhibits leucocyte adhesion under flow. Atherosclerosis, .

Xu, SZ; Sukumar, P; Zeng, F; Li, J; Jairaman, A; English, A; Naylor, J; Ciurtin, C; Majeed, Y; Milligan, CJ; Bahnasi, YM; Al-Shawaf, E; Porter, KE; Jiang, LH; Emery, P; Sivaprasadarao, A; Beech, DJ (2008) TRPC channel activation by extracellular thioredoxin.. Nature, 451 (7174), pp. 69-72.

Guy, JL; Lambert, DW; Turner, NA; Porter, KE (2008) Functional ACE2 is expressed in human cardiac myofibroblasts. Experimental Physiology, 93 , pp. 579-588.

Riches, K; Morley, ME; Peers, C; Porter, KE (2007) Furin regulates hypoxic inhibition of MMP-2 activation in human cardiac fibroblasts. None, 88 (6), pp. A88.

Morley, ME; Riches, K; Peers, C; Porter, KE (2007) Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodeling. Biochemical Society Transactions, 35 (5), pp. 905-907.

Turner, NA; Midgley, L; O'Regan, DJ; Porter, KE (2007) Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J CARDIOVASC PHARM, 50 (4), pp. 458-461.

Turner, NA; Mughal, RS; Warburton, P; O'Regan, DJ; Ball, SG; Porter, KE (2007) Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones.. Cardiovasc Res, 76 (1), pp. 81-90.

Turner, NA; Hall, KT; Ball, SG; Porter, KE (2007) Selective gene silencing of either MMP-2 or MMP-9 inhibits invasion of human saphenous vein smooth muscle cells.. Atherosclerosis, 193 (1), pp. 36-43.

Turner, NA; Hall, KT; Ball, SG; Porter, KE (2007) Selective gene silencing of either MMP-2 or MMP-9 inhibits invasion of human saphenous vein smooth muscle cells. ATHEROSCLEROSIS, 193 (1), pp. 36-43.

Turner, NA; Ho, S; Warburton, P; O'Regan, DJ; Porter, KE (2007) Smooth muscle cells cultured from human saphenous vein exhibit increased proliferation, invasion, and mitogen-activated protein kinase activation in vitro compared with paired internal mammary artery cells.. J Vasc Surg, 45 (5), pp. 1022-1028.

Turner, NA; Aley, P; Hall, KT; Warburton, P; Galloway, S; Midgley, L; O'Regan, DJ; Wood, IC; Ball, SG; Porter, KE (2007) Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms. Journal of Molecular and Cellular Cardiology, (43), pp. 168-176.

Xu, SZ; Muraki, K; Zeng, F; Li, J; Sukumar, P; Shah, S; Dedman, AM; Flemming, PK; McHugh, D; Naylor, J; Cheong, A; Bateson, AN; Munsch, CM; Porter, KE; Beech, DJ (2006) A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility.. Circ Res, 98 (11), pp. 1381-1389.

Kumar, B; Dreja, K; Shah, SS; Cheong, A; Xu, SZ; Sukumar, P; Naylor, J; Forte, A; Cipollaro, M; McHugh, D; Kingston, PA; Heagerty, AM; Munsch, CM; Bergdahl, A; Hultgardh-Nilsson, A; Gomez, MF; Porter, KE; Hellstrand, P; Beech, DJ (2006) Upregulated TRPC1 Channel in Vascular Injury In Vivo and Its Role in Human Neointimal Hyperplasia. Circulation Research, 98 (4), pp. 557-563.

Peers, C; Kang, P; Boyle, JP; Porter, KE; Pearson, HA; Smith, IF; Kemp, PJ (2006) Hypoxic regulation of Ca2+ signalling in astrocytes and endothelial cells.. Novartis Found Symp, 272 , pp. 119-127.

Peers, C; Aley, PK; Boyle, JP; Porter, KE; Pearson, HA; Smith, IF; Kemp, PJ (2006) Hypoxic regulation of Ca2+ signaling in astrocytes and endothelial cells. Advances in Experimental Medicine and Biology, 580 , pp. 185-190.

Cheong, A; Bingham, AJ; Li, J; Kumar, B; Sukumar, P; Munsch, C; Buckley, NJ; Neylon, CB; Porter, KE; Beech, DJ; Wood, IC (2005) Downregulated REST Transcription Factor Is a Switch Enabling Critical Potassium Channel Expression and Cell Proliferation. Molecular Cell, 20 (1), pp. 45-52.

Turner, NA; O'Regan, DJ; Ball, SG; Porter, KE (2005) Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels.. FASEB J, 19 (7), pp. 804-806.

Turner, NA; O'Regan, DJ; Ball, SG; Porter, KE (2005) Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. The FASEB Journal, 19 (7), pp. 1-21.

Corpataux, JM; Naik, J; Porter, KE; London, NJ (2005) A comparison of six statins on the development of intimal hyperplasia in a human vein culture model. European Journal of Vascular and Endovascular Surgery, 29 (2), pp. 177-181.

Aley, PK; Porter, KE; Boyle, JP; Kemp, PJ; Peers, C (2005) Hypoxic modulation of CA2+ signaling in human venous endothelial cells: Multiple roles for reactive oxygen species. Journal of Biological Chemistry, 280 (14), pp. 13349-13354.

Corpataux, JM; Naik, J; Porter, KE; London, NJM (2005) The effect of six different statins on the proliferation, migration and invasion of human smooth muscle cells. . Journal of Surgical Research, 129 (52-56).

Turner, NA; O'regan, DJ; Ball, SG; Porter, KE (2004) Endothelin-1 is an essential co-factor for beta2-adrenergic receptor-induced proliferation of human cardiac fibroblasts.. FEBS Lett, 576 (1-2), pp. 156-160.

Porter, KE; Turner, NA; O'Regan, DJ; Ball, SG (2004) Tumor necrosis factor α induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin. Cardiovascular Research, 64 (3), pp. 507-515.

Porter, KE; Turner, NA; O'Regan, DJ; Balmforth, AJ; Ball, SG (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. CARDIOVASC RES, 61 (4), pp. 745-755.

Turner, NA; Porter, KE; Smith, WHT; White, HL; Ball, SG; Balmforth, AJ (2003) Chronic beta(2)-adrenergic receptor stimulation increases proliferation of human cardiac fibroblasts via an autocrine mechanism. CARDIOVASC RES, 57 (3), pp. 784-792.

Porter, KE; Naik, J; Turner, NA; Dickinson, T; Thompson, MM; London, NJ (2002) Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration.. J Vasc Surg, 36 (1), pp. 150-157.

Porter, KE; Turner, NA (2002) Statins for the prevention of vein graft stenosis: a role for inhibition of matrix metalloproteinase-9. BIOCHEMICAL SOCIETY TRANSACTIONS, 30 , pp. 120-126.

Arun, C; Swift, B; Porter, KE; West, KP; London, NJ; Hemingway, DM (2002) The role of big endothelin-1 in colorectal cancer. International Journal of Biological Markers, 17 (4), pp. 268-274.

Porter, KE (2002) Use of in vitro organ cultures of human saphenous vein as a model for intimal proliferation.. Methods Mol Biol, 206 , pp. 199-214.

Porter, KE (2002) Use of in vitro organ cultures of human saphenous vein as a model for intimal proliferation. Methods in Molecular Biology, 206 , pp. 199-216.

Goodall, S; Porter, KE; Bell, PR; Thompson, MM (2002) Enhanced invasive properties exhibited by smooth muscle cells is associated with elavated production of MMP-2 in patients with aortic aneurysms. European Journal of Vascular and Endovascular Surgery, 24 (1), pp. 72-80.

Porter, KE; Dickinson, T; London, NJM (2001) Inhibition of neointima formation in an organ culture of human saphenous vein: A comparison of dual endothelin-converting enzyme/neutral endopeptidase and selective neutral endopeptidase inhibition. J VASC SURG, 34 (3), pp. 548-554.

Teaching Commitments

MBChB Year 1 - Introduction to Medical Science (MEDI1216) - Lecturer for Membranes, Lipids and Signalling.

MBChB Year 1 - Research, Evaluation and Special Studies 1 (MEDI1213) - RESS Tutor.
 
MBChB Year 2 - Student Selected Components - SSC2.1 tutor.
Intercalated BSc in Clinical Sciences - project supervisor (since 2005)

Widening Participation

Invited talks at BHF fundraising events - increasing awareness of the importance of BHF funding to cardiovascular research.
 
BBC TV News interview on our laboratory work with statin drugs
 
BBC Radio Leeds live interview on work recently published
 
Year 10 work experience students