The objective in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is to measure hemodynamic parameters (tissue perfusion, vascularity, permeability, etc.) from MRI images acquired at high temporal resolution during the injection of an contrast agent. Clinically, the measured parameters characterize tissue function or metabolic activity, and may be used to improve diagnosis, to plan interventions or therapy, or serve as biomarkers to evaluate the response to therapy. My work is situated on three different levels: (i) Development of methods to improve the accuracy and precision of the measured parameters, and extract a maximum amount of information on tissue status. (ii) Implementation and evaluation of those methods in clinical, preclinical and experimental studies, in collaboration with clinical partners. (iii) Development of software tools to streamline the interaction between method development and clinical application.

Huber A; Sourbron S; Klauss V; Schaefer J; Bauner KU; Schweyer M; Reiser M; Rummeny E; Rieber J (2012) Magnetic resonance perfusion of the myocardium: semiquantitative and quantitative evaluation in comparison with coronary angiography and fractional flow reserve.. Invest Radiol, 47 (6), pp. 332-338.

Ingrisch M; Sourbron S; Morhard D; Ertl-Wagner B; Kuempfel T; Hohlfeld R; Reiser M; Glaser C (2012) Quantification of Perfusion and Permeability in Multiple Sclerosis Dynamic Contrast-Enhanced MRI in 3D at 3T. INVESTIGATIVE RADIOLOGY, 47 , pp. 252-258.

Sommer WH; Sourbron S; Huppertz A; Ingrisch M; Reiser MF; Zech CJ (2012) Contrast agents as a biological marker in magnetic resonance imaging of the liver: conventional and new approaches. ABDOMINAL IMAGING, 37 , pp. 164-179.

Broadbent DA; Biglands JD; Larghat AM; Sourbron S; Plein S; Buckley DL (2012) Myocardial microvascular function at rest and stress measured with dynamic contrast-enhanced MRI.. J Cardiovasc Magn Reson, 14 Suppl 1 , pp. P283.

Cyran CC; Paprottka PM; Schwarz B; Sourbron S; Ingrisch M; Von Einem J; Pietsch H; Dietrich O; Hinkel R; Bruns CJ; Reiser MF; Wintersperger BJ; Nikolaou K (2012) Perfusion MRI for Monitoring the Effect of Sorafenib on Experimental Prostate Carcinoma: A Validation Study. AMERICAN JOURNAL OF ROENTGENOLOGY, 198 , pp. 384-391.

Sourbron SP; Buckley DL (2012) Tracer kinetic modelling in MRI: estimating perfusion and capillary permeability. PHYSICS IN MEDICINE AND BIOLOGY, 57 , pp. R1-R33.

Bauner KU; Sourbron S; Picciolo M; Schmitz C; Theisen D; Sandner TA; Reiser MF; Huber AM (2012) MR first pass perfusion of benign and malignant cardiac tumours-significant differences and diagnostic accuracy. EUROPEAN RADIOLOGY, 22 , pp. 73-82.

Notohamiprodjo M; Pedersen M; Glaser C; Helck AD; Lodemann K; Jespersen B; Fischereder M; Reiser MF; Sourbron SP (2011) Comparison of Gd-DTPA and Gd-BOPTA for Studying Renal Perfusion and Filtration. JOURNAL OF MAGNETIC RESONANCE IMAGING, 34 , pp. 595-607.

Cyran CC; Sourbron S; Bochmann K; Habs M; Pfefferkorn T; Rominger A; Raya JG; Reiser MF; Dichgans M; Nikolaou K; Hacker M; Saam T (2011) Quantification of Supra-Aortic Arterial Wall Inflammation in Patients With Arteritis Using High Resolution Dynamic Contrast-Enhanced Magnetic Resonance Imaging Initial Results in Correlation to [F-18]-FDG PET/CT. INVESTIGATIVE RADIOLOGY, 46 , pp. 594-599.

Sourbron SP; Buckley DL (2011) On the Scope and Interpretation of the Tofts Models for DCE-MRI. MAGNETIC RESONANCE IN MEDICINE, 66 , pp. 735-745.

Luypaert R; Sourbron S; de Mey J (2011) Validity of Perfusion Parameters Obtained Using the Modified Tofts Model: A Simulation Study. MAGNETIC RESONANCE IN MEDICINE, 65 , pp. 1491-1497.

Luypaert R; Sourbron S; de Mey J (2011) Validity of perfusion parameters obtained using the modified Tofts model: a simulation study.. Magn Reson Med, 65 (5), pp. 1491-1497.

Biffar A; Sourbron S; Dietrich O; Schmidt G; Ingrisch M; Reiser MF; Baur-Melnyk A (2011) Combined diffusion-weighted and dynamic contrast-enhanced imaging of patients with acute osteoporotic vertebral fractures (vol 76, pg 298, 2010). EUROPEAN JOURNAL OF RADIOLOGY, 77 , pp. 528-528.

Biffar A; Schmidt GP; Sourbron S; D'Anastasi M; Dietrich O; Notohamiprodjo M; Reiser MF; Baur-Melnyk A (2011) Quantitative Analysis of Vertebral Bone Marrow Perfusion Using Dynamic Contrast-Enhanced MRI: Initial Results in Osteoporotic Patients With Acute Vertebral Fracture. JOURNAL OF MAGNETIC RESONANCE IMAGING, 33 , pp. 676-683.

Benson AP; Bernus O; Dierckx H; Gilbert SH; Greenwood JP; Holden AV; Mohee K; Plein S; Radjenovic A; Ries ME; Smith GL; Sourbron S; Walton RD (2011) Construction and validation of anisotropic and orthotropic ventricular geometries for quantitative predictive cardiac electrophysiology. INTERFACE FOCUS, 1 , pp. 101-116.

Schlemmer M; Sourbron SP; Schinwald N; Nikolaou K; Becker CR; Reiser MF; Berger F (2011) Perfusion patterns of metastatic gastrointestinal stromal tumor lesions under specific molecular therapy. EUROPEAN JOURNAL OF RADIOLOGY, 77 , pp. 312-318.

Bauner KU; Sourbron S; Picciolo M; Schmitz C; Theisen D; Sandner TA; Reiser MF; Huber AM (2011) MR first pass perfusion of benign and malignant cardiac tumours-significant differences and diagnostic accuracy. European Radiology, , pp. 1-10.

Dujardin MI; Sourbron SP; Chaskis C; Verellen D; Stadnik T; de Mey J; Luypaert R (2011) Quantification of cerebral tumour blood flow and permeability with T1-weighted dynamic contrast enhanced MRI: A feasibility study. Journal of Neuroradiology, .

Biffar A; Sourbron S; Dietrich O; Schmidt G; Ingrisch M; Reiser MF; Baur-Melnyk A (2011) Erratum: Combined diffusion-weighted and dynamic contrast-enhanced imaging of patients with acute osteoporotic vertebral fractures (European Journal of Radiology (2010) 76 (298-303)). European Journal of Radiology, 77 (3), pp. 528-528.

Sommer WH; Sourbron S; Huppertz A; Ingrisch M; Reiser MF; Zech CJ (2011) Contrast agents as a biological marker in magnetic resonance imaging of the liver: conventional and new approaches. Abdominal Imaging, , pp. 1-16.

Attenberger UI; Sourbron SP; Michaely HJ; Reiser MF; Schoenberg SO (2010) Retrospective respiratory triggering renal perfusion MRI. ACTA RADIOLOGICA, 51 , pp. 1163-1171.

Sourbron S (2010) Technical aspects of MR perfusion. EUROPEAN JOURNAL OF RADIOLOGY, 76 , pp. 304-313.

Notohamiprodjo M; Reiser MF; Sourbron SP (2010) Diffusion and perfusion of the kidney. EUROPEAN JOURNAL OF RADIOLOGY, 76 , pp. 337-347.

Biffar A; Dietrich O; Sourbron S; Duerr H; Reiser MF; Baur-Melnyk A (2010) Diffusion and perfusion imaging of bone marrow. EUROPEAN JOURNAL OF RADIOLOGY, 76 , pp. 323-328.

Biffar A; Sourbron S; Dietrich O; Schmidt G; Ingrisch M; Reiser MF; Baur-Melnyk A (2010) Combined diffusion-weighted and dynamic contrast-enhanced imaging of patients with acute osteoporotic vertebral fractures. EUROPEAN JOURNAL OF RADIOLOGY, 76 , pp. 298-303.

Luypaert R; Sourbron S; Makkat S; de Mey J (2010) Error estimation for perfusion parameters obtained using the two-compartment exchange model in dynamic contrast-enhanced MRI: a simulation study. PHYSICS IN MEDICINE AND BIOLOGY, 55 , pp. 6431-6443.

Helck A; Sommer WH; Klotz E; Wessely M; Sourbron SP; Nikolaou K; Clevert DA; Notohamiprodjo M; Illner WD; Reiser M; Becker HC (2010) Determination of glomerular filtration rate using dynamic CT-angiography: simultaneous acquisition of morphological and functional information.. Invest Radiol, 45 (7), pp. 387-392.

Biffar A; Sourbron S; Schmidt G; Ingrisch M; Dietrich O; Reiser MF; Baur-Melnyk A (2010) Measurement of Perfusion and Permeability From Dynamic Contrast-Enhanced MRI in Normal and Pathological Vertebral Bone Marrow. MAGNETIC RESONANCE IN MEDICINE, 64 , pp. 115-124.

Schlossbauer T; Sourbron S; Scholz A; Mosner M; Kahlert S; Boehm H; Reiser M; Hellerhoff K (2010) Dynamic Breast MRI in the Course of Neoadjuvant Chemotherapy: Standardized Evaluation of Tumor Size and Enhancement Parameters in Correlation to Different Histopathologic Characteristics. ACADEMIC RADIOLOGY, 17 , pp. 441-449.

Donaldson SB; West CML; Davidson SE; Carrington BM; Hutchison G; Jones AP; Sourbron SP; Buckley DL (2010) A Comparison of Tracer Kinetic Models for T-1-Weighted Dynamic Contrast-Enhanced MRI: Application in Carcinoma of the Cervix. MAGNETIC RESONANCE IN MEDICINE, 63 , pp. 691-700.

Makkat S; Luypaert R; Sourbron S; Stadnik T; De Mey J (2010) Assessment of Tumor Blood Flow in Breast Tumors With T1-Dynamic Contrast-Enhanced MR Imaging: Impact of Dose Reduction and the Use of a Prebolus Technique on Diagnostic Efficacy. JOURNAL OF MAGNETIC RESONANCE IMAGING, 31 , pp. 556-561.

Cyran C; Paprottka P; Sourbron S; Einem J; Hinkel R; Schwarz B; Bruns C; Dietrich O; Wintersperger B; Nikolaou K; Reiser M (2010) Treatment monitoring anti-angiogenic Effects of Sorafenib on experimental Prostate cancer with dynamic, contrast-enhanced (DCE) MRI and macromolecular Contrast agent.. ONKOLOGIE, 33 , pp. 162-163.

Notohamiprodjo M; Sourbron S; Staehler M; Michaely HJ; Attenberger UI; Schmidt GR; Boehm H; Horng A; Glaser C; Stief C; Reiser MF; Herrmann KA (2010) Measuring Perfusion and Permeability in Renal Cell Carcinoma With Dynamic Contrast-Enhanced MRI: A Pilot Study. JOURNAL OF MAGNETIC RESONANCE IMAGING, 31 , pp. 490-501.

Attenberger UI; Sourbron SP; Schoenberg SO; Morelli J; Leiner T; Schoeppler GM; Samtleben W; Birkemeier KL; Glaser C; Reiser MF; Michaely HJ (2010) Comprehensive MR evaluation of renal disease: added clinical value of quantified renal perfusion values over single MR angiography.. J Magn Reson Imaging, 31 (1), pp. 125-133.

Ingrisch M; Dietrich O; Attenberger UI; Nikolaou K; Sourbron S; Reiser MF; Fink C (2010) Quantitative Pulmonary Perfusion Magnetic Resonance Imaging Influence of Temporal Resolution and Signal-to-Noise Ratio. INVESTIGATIVE RADIOLOGY, 45 , pp. 7-14.

Sourbron S (2010) Compartmental modelling for magnetic resonance renography. ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK, 20 , pp. 101-114.

Sourbron S; Heilmann M; Biffar A; Walczak C; Vautier J; Volk A; Peller M (2009) Bolus-Tracking MRI with a Simultaneous T(1)- and T(2)*-Measurement. MAGNETIC RESONANCE IN MEDICINE, 62 , pp. 672-681.

Sourbron S; Ingrisch M; Siefert A; Reiser M; Herrmann K (2009) Quantification of Cerebral Blood Flow, Cerebral Blood Volume, and Blood-Brain-Barrier Leakage with DCE-MRI. MAGNETIC RESONANCE IN MEDICINE, 62 , pp. 205-217.

Duiardin M; Luypaert R; Vandenbroucke F; Van der Niepen P; Sourbron S; Verbeelen D; Stadnik T; de Mey J (2009) Combined T1-based perfusion MRI and MR angiography in kidney: First experience in normals and pathology. EUROPEAN JOURNAL OF RADIOLOGY, 69 , pp. 542-549.

Dujardin M; Luypaert R; Sourbron S; Verbeelen D; Stadnik T; de Mey J (2009) Age Dependence of T1 Perfusion MRI-Based Hemodynamic Parameters in Human Kidneys. JOURNAL OF MAGNETIC RESONANCE IMAGING, 29 , pp. 398-403.

Peller M; Schwerdt A; Hossann M; Reinl HM; Wang T; Sourbron S; Ogris M; Lindner LH (2008) MR Characterization of Mild Hyperthermia-Induced Gadodiamide Release From Thermosensitive Liposomes in Solid Tumors. INVESTIGATIVE RADIOLOGY, 43 , pp. 877-892.

Makkat S; Luypaert R; Stadnik T; Bourgain C; Sourbron S; Dujardin M; De Greve J; De Mey J (2008) Deconvolution-based Dynamic Contrast-enhanced MR Imaging of Breast Tumors: Correlation of Tumor Blood Flow with Human Epidermal Growth Factor Receptor 2 Status and Clinicopathologic Findings-Preliminary Results. RADIOLOGY, 249 , pp. 471-482.

Attenberger UI; Michaely HJ; Wintersperger BJ; Sourbron SP; Lodemann K; Reiser MF; Schoenberg SO (2008) Three-dimensional contrast-enhanced magnetic-resonance angiography of the renal arteries: Interindividual comparison of 0.2 mmol/kg gadobutrol at 1.5 T and 0.1 mmol/kg gadobenate dimeglumine at 3.0 T. EUROPEAN RADIOLOGY, 18 , pp. 1260-1268.

Michaely HJ; Sourbron SP; Buettner C; Lodemann K; Reiser MF; Schoenberg SO (2008) Temporal constraints in renal perfusion imaging with a 2-compartment model. INVESTIGATIVE RADIOLOGY, 43 , pp. 120-128.

Sourbron SP; Michaely HJ; Reiser MF; Schoenberg SO (2008) MRI-measurement of perfusion and glomerular filtration in the human kidney with a separable compartment model. INVESTIGATIVE RADIOLOGY, 43 , pp. 40-48.

Attenberger UI; Sourbron SP; Notohamiprodjo M; Lodemann KP; Glaser CG; Reiser MF; Schoenberg SO; Michaely HJ (2008) MR-based semi-automated quantification of renal functional parameters with a two-compartment model--an interobserver analysis.. Eur J Radiol, 65 (1), pp. 59-65.

Sourbron S; Luypaert R; Morhard D; Seelos K; Reiser M; Peller M (2007) Deconvolution of bolus-tracking data: a comparison of discretization methods. PHYSICS IN MEDICINE AND BIOLOGY, 52 , pp. 6761-6778.

Michaely HJ; Sourbron S; Dietrich O; Attenberger U; Reiser MF; Schoenberg SO (2007) Functional renal MR imaging: an overview. ABDOMINAL IMAGING, 32 , pp. 758-771.

Makkat S; Luypaert R; Sourbron S; Stadnik T; De Mey J (2007) Quantification of perfusion and permeability in breast tumors with a deconvolution-based analysis of second-bolus T1-DCE data. JOURNAL OF MAGNETIC RESONANCE IMAGING, 25 , pp. 1159-1167.

Michaely HJ; Kramer H; Attenberger U; Sourbron SP; Weckbach S; Reiser MF; Schoenberg SO (2007) Renal magnetic resonance angiography at 3.0 T: technical feasibility and clinical perspectives.. Top Magn Reson Imaging, 18 (2), pp. 117-125.

Sourbron S; Dujardin M; Makkat S; Luypaert R (2007) Pixel-by-pixel deconvolution of bolus-tracking data: optimization and implementation. PHYSICS IN MEDICINE AND BIOLOGY, 52 , pp. 429-447.

Dujardin M; Sourbron S; Luypaert R; Verbeelen D; Stadnik T (2005) Quantification of renal perfusion and function on a voxel-by-voxel basis: A feasibility study. MAGNETIC RESONANCE IN MEDICINE, 54 , pp. 841-849.

Sourbron S; Luypaert R; Van Schuerbeek P; Dujardin M; Stadnik T (2004) Choice of the regularization parameter for perfusion quantification with MRI. PHYSICS IN MEDICINE AND BIOLOGY, 49 , pp. 3307-3324.

Sourbron S; Luypaert R; Van Schuerbeek P; Dujardin M; Stadnik T; Osteaux M (2004) Deconvolution of dynamic contrast-enhanced MRI data by linear inversion: Choice of the regularization parameter. MAGNETIC RESONANCE IN MEDICINE, 52 , pp. 209-213.

Boujraf S; Luypaert R; Shabana W; De Meirleir L; Sourbron S; Osteaux M (2002) Study of pediatric brain development using magnetic resonance imaging of anisotropic diffusion. MAGNETIC RESONANCE IMAGING, 20 , pp. 327-336.

Luypaert R; Boujraf S; Sourbron S; Osteaux M (2001) Diffusion and perfusion MRI: basic physics. EUROPEAN JOURNAL OF RADIOLOGY, 38 , pp. 19-27.

Sourbron S (2000) A note on causal duality. FOUNDATIONS OF PHYSICS LETTERS, 13 , pp. 357-367.