Professor John Trinick
BSc, PhD 1973, Leicester.
Professor of Animal Cell Biology
Institute of Molecular and Cellular Biology
Office: Manton 5.93e
Phone: +44(0) 113 34 34350
Email: j.trinick@leeds.ac.uk
Centre membership: The Astbury Centre for Structural Molecular Biology
You can read more about Professor Trinick's interests here:
www.astbury.leeds.ac.uk/People/staffpage.php?StaffID=JT
www.contractility.org
Research Interests
Molecular motors, bioelasticity, giant proteins, cryo-electron microscopy
Studentship information
Postgraduate studentship areas:
- The role of the giant protein titin in muscle assembly and elasticity; High resolution structural studies of molecules of the myosin superfamily by electron microscopy and image processing (with Dr Peter Knight)
See also:
- Faculty Graduate School
- Project details at FindaPhD.com
Publications
Czajlik A; Thompson GS; Khan GN; Kalverda AP; Homans SW; Trinick J 1H, 15N and 13C backbone chemical shift assignment of the titin A67-A68 domain tandem Biomolecular NMR Assignments 6 39-41, 2012
Kennaway CK; Taylor JE; Song CF; Potrzebowski W; Nicholson W; White JH; Swiderska A; Obarska-Kosinska A; Callow P; Cooper LP; Roberts GA; Artero J; Bujnicki JM; Trinick J; Kneale GG; Dryden DTF Structure and operation of the DNA-translocating type I DNA restriction enzymes GENES&DEVELOPMENT 26 92-104, 2012
DOI:10.1101/gad.179085.111
Tskhovrebova L; Trinick J Making Muscle Elastic: The Structural Basis of Myomesin Stretching PLOS BIOLOGY 10 -, 2012
DOI:10.1371/journal.pbio.1001264
Muench SP; Trinick J; Harrison MA Structural divergence of the rotary ATPases QUARTERLY REVIEWS OF BIOPHYSICS 44 311-356, 2011
DOI:10.1017/S0033583510000338
Tassieri M; Waigh TA; Trinick J; Aggeli A; Evans RML Analysis of the linear viscoelasticity of polyelectrolytes by magnetic microrheometry-Pulsed creep experiments and the one particle response JOURNAL OF RHEOLOGY 54 117-131, 2010
DOI:10.1122/1.3266946
Nicholson WV; White H; Trinick J An approach to automated acquisition of cryoEM images from lacey carbon grids JOURNAL OF STRUCTURAL BIOLOGY 172 395-399, 2010
DOI:10.1016/j.jsb.2010.08.014
Song CF; Sader K; White H; Kendrick-Jones J; Trinick J Nucleotide-Dependent Shape Changes in the Reverse Direction Motor, Myosin VI BIOPHYSICAL JOURNAL 99 3336-3344, 2010
DOI:10.1016/j.bpj.2010.09.014
Tskhovrebova L; Trinick J Roles of Titin in the Structure and Elasticity of the Sarcomere JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY -, 2010
DOI:10.1155/2010/612482
Tskhovrebova L; Walker ML; Grossmann JG; Khan GN; Baron A; Trinick J Shape and Flexibility in the Titin 11-Domain Super-Repeat JOURNAL OF MOLECULAR BIOLOGY 397 1092-1105, 2010
DOI:10.1016/j.jmb.2010.01.073
Oke OA; Burgess SA; Forgacs E; Knight PJ; Sakamoto T; Sellers JR; White H; Trinick J Influence of lever structure on myosin 5a walking PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107 2509-2514, 2010
DOI:10.1073/pnas.0906907107
Kennaway CK; Obarska-Kosinska A; White JH; Tuszynska I; Cooper LP; Bujnicki JM; Trinick J; Dryden DTF The structure of M.EcoKI Type I DNA methyltransferase with a DNA mimic antirestriction protein, 2009
DOI:10.1093/nar/gkn988
Pan Y; Sader K; Powell JJ; Bleloch A; Gass M; Trinick J; Warley A; Li A; Brydson R; Brown A 3D morphology of the human hepatic ferritin mineral core: New evidence for a subunit structure revealed by single particle analysis of HAADF-STEM images JOURNAL OF STRUCTURAL BIOLOGY 166 22-31, 2009
DOI:10.1016/j.jsb.2008.12.001
Sader K; Studer D; Zuber B; Gnaegi H; Trinick J Preservation of high resolution protein structure by cryo-electron microscopy of vitreous sections ULTRAMICROSCOPY 110 43-47, 2009
DOI:10.1016/j.ultramic.2009.09.004
Muench SP; Huss M; Song CF; Phillips C; Wieczorek H; Trinick J; Harrison MA Cryo-electron Microscopy of the Vacuolar ATPase Motor Reveals its Mechanical and Regulatory Complexity JOURNAL OF MOLECULAR BIOLOGY 386 989-999, 2009
DOI:10.1016/j.jmb.2009.01.014
Houmeida A; Baron A; Keen J; Khan GN; Knight PJ; III SWF; Thirumurugan K; Thompson B; Tskhovrebova L; Trinick J Evidence for the Oligomeric State of 'Elastic' Titin in Muscle Sarcomeres JOURNAL OF MOLECULAR BIOLOGY 384 299-312, 2008
DOI:10.1016/j.jmb.2008.09.030
Tassieri M; Evans RML; Barbu-Tudoran L; Trinick J; Waigh TA The self-assembly, elasticity, and dynamics of cardiac thin filaments BIOPHYSICAL JOURNAL 94 2170-2178, 2008
DOI:10.1529/biophysj.107.116087
Tassieri M; Evans RML; Barbu-Tudoran L; Khaname GN; Trinick J; Waigh TA Dynamics of Semiflexible Polymer Solutions in the Highly Entangled Regime PHYSICAL REVIEW LETTERS 101 -, 2008
DOI:10.1103/PhysRevLett.101.198301
Lukoyanova N; Baldwin SA; Trinick J 3D reconstruction of mammalian septin filaments JOURNAL OF MOLECULAR BIOLOGY 376 1-7, 2008
DOI:10.1016/j.jmb.2007.11.029
Tskhovrebova L; Trinick J Giant Proteins: Sensing Tension with Titin Kinase CURRENT BIOLOGY 18 R1141-R1142, 2008
DOI:10.1016/j.cub.2008.10.035
Pan Y; Brown AP; Sader K; Trinick J; Brydson R; Bleloch A; Gass M Aberration corrected scanning TEM applied to biological specimens MICROSCOPY AND MICROANALYSIS 13 132-133, 2007
DOI:10.1017/S1431927607072595
Sader K; Reedy M; Popp D; Lucaveche C; Trinick J Measuring the resolution of uncompressed plastic sections cut using an oscillating knife ultramicrotome JOURNAL OF STRUCTURAL BIOLOGY 159 29-35, 2007
DOI:10.1016/j.jsb.2007.01.019
Di Cola E; Waigh TA; Trinick J; Tskhovrebova L; Houmeida A; Pyckhout-Hintzen W; Dewhurst C Persistence length of titin from rabbit skeletal muscles measured with scattering and microrheology techniques BIOPHYSICAL JOURNAL 88 4095-4106, 2005
DOI:10.1529/biophysj.104.054908
Stafford WF; Walker ML; Trinick JA; Coluccio LM Mammalian class I myosin, Myo1b, is monomeric and cross-links actin filaments as determined by hydrodynamic studies and electron microscopy BIOPHYSICAL JOURNAL 88 384-391, 2005
DOI:10.1529/biophysj.104.045245
Tskhovrebova L; Trinick J Muscle disease: a giant feels the strain NATURE MEDICINE 11 478-479, 2005
DOI:10.1038/nm0505-478
Tskhovrebova L; Houmeida A; Trinick J Can the passive elasticity of muscle be explained directly from the mechanics of individual titin molecules? JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 26 285-289, 2005
DOI:10.1007/s10974-005-9034-5
Roberts R; Lister I; Schmitz S; Walker M; Veigel C; Trinick J; Buss F; Kendrick-Jones J Myosin VI: cellular functions and motor properties PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 359 1931-1944, 2004
DOI:10.1098/rstb.2004.1563
Lister I; Schmitz S; Walker M; Trinick J; Buss F; Veigel C; Kendrick-Jones J A monomeric myosin VI with a large working stroke EMBO JOURNAL 23 1729-1738, 2004
DOI:10.1038/sj.emboj.7600180
Lister I; Roberts R; Schmitz S; Walker M; Trinick J; Veigel C; Buss F; Kendrick-Jones J Myosin VI: a multifunctional motor BIOCHEMICAL SOCIETY TRANSACTIONS 32 685-688, 2004
Burgess SA; Walker ML; Thirumurugan K; Trinick J; Knight PJ Use of negative stain and single-particle image processing to explore dynamic properties of flexible macromolecules JOURNAL OF STRUCTURAL BIOLOGY 147 247-258, 2004
DOI:10.1016/j.jsb.2004.04.004
Tskhovrebova L; Trinick J Properties of titin immunoglobulin and fibronectin-3 domains JOURNAL OF BIOLOGICAL CHEMISTRY 279 46351-46354, 2004
DOI:10.1074/jbc.R400023200
Trinick J Professor Koscak Maruyama (1930-2003) - Obituary JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 25 283-283, 2004
Burgess S; Walker M; Knight PJ; Sparrow J; Schmitz S; Offer G; Bullard B; Leonard K; Holt J; Trinick J Structural studies of arthrin: Monoubiquitinated actin JOURNAL OF MOLECULAR BIOLOGY 341 1161-1173, 2004
DOI:10.1016/j.jmb.2004.06.077
Mutungi G; Trinick J; Ranatunga KW Resting tension characteristics in differentiating intact rat fast- and slow-twitch muscle fibers JOURNAL OF APPLIED PHYSIOLOGY 95 2241-2247, 2003
DOI:10.1152/japplphysiol.00990.2002
Tskhovrebova L; Trinick J Titin: Properties and family relationships NATURE REVIEWS MOLECULAR CELL BIOLOGY 4 679-689, 2003
DOI:10.1038/nrm1198
White HD; Thirumurugan K; Walker ML; Trinick J A second generation apparatus for time-resolved electron cryo-microscopy using stepper motors and electrospray JOURNAL OF STRUCTURAL BIOLOGY 144 246-252, 2003
DOI:10.1016/j.jsb.2003.09.027
Trinick J; Tskhovrebova LA Giant protein titin: structural and functional aspects In Elastomeric Proteins , 2003
Harrison M; Durose L; Song CF; Barratt E; Trinick J; Jones R; Findlay JBC Structure and function of the vacuolar H+-ATPase: Moving from low-resolution models to high-resolution structures JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 35 337-345, 2003
DOI:10.1023/A:1025728915565
Tskhovrebova L; Trinick J Role of titin in vertebrate striated muscle PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 357 199-206, 2002
DOI:10.1098/rstb.2001.1028
Brockwell DJ; Beddard GS; Clarkson J; Zinober RC; Blake AW; Trinick J; Olmsted PD; Smith DA; Radford SE The effect of core destabilization on the mechanical resistance of I27 BIOPHYSICAL JOURNAL 83 458-472, 2002
Burgess S; Walker M; Wang F; Seller JR; White HD; Knight PJ; Trinick J The prepower stroke conformation of myosin V JOURNAL OF CELL BIOLOGY 159 983-991, 2002
DOI:10.1083/jcb.200208172
Tskhovrebova L; Trinick J Flexibility and extensibility in the titin molecule: Analysis of electron microscope data JOURNAL OF MOLECULAR BIOLOGY 310 755-771, 2001
DOI:10.1006/jmbi.2001.4700
Liversage AD; Holmes D; Knight PJ; Tskhovrebova L; Trinick J Titin and the sarcomere symmetry paradox JOURNAL OF MOLECULAR BIOLOGY 305 401-409, 2001
DOI:10.1006/jmbi.2000.4279
Calaghan SC; Trinick J; Knight PJ; White E A role for C-protein in the regulation of contraction and intracellular Ca2+ in intact rat ventricular myocytes JOURNAL OF PHYSIOLOGY-LONDON 528 151-156, 2000
DOI:10.1111/j.1469-7793.2000.00151.x
Tskhovrebova L; Trinick J Extensibility in the titin molecule and its relation to muscle elasticity, 2000
Walker ML; Burgess SA; Sellers JR; Wang F; Hammer JA; Trinick J; Knight PJ Two-headed binding of a processive myosin to F-actin NATURE 405 804-+, 2000
Tskhovrebova L; Trinick J Extensibility in the titin molecule and its relation to muscle elasticity ELASTIC FILAMENTS OF THE CELL 481 163-178, 2000
Calaghan SC; Trinick J; Knight PJ; White E A role for C-protein in the regulation of contraction and intracellular Ca2+ in intact rat ventricular myocytes Journal of Physiology 528 151-156, 2000
Trinick J; Tskhovrebova L Titin: a molecular control freak TRENDS IN CELL BIOLOGY 9 377-380, 1999
DOI:10.1016/S0962-8924(99)01641-4
Walker M; Zhang XZ; Jiang W; Trinick J; White HD Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: Evidence that the start of the crossbridge power stroke in muscle has variable geometry PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96 465-470, 1999
DOI:10.1073/pnas.96.2.465
White HD; Walker ML; Trinick J A computer-controlled spraying-freezing apparatus for millisecond time-resolution electron cryomicroscopy JOURNAL OF STRUCTURAL BIOLOGY 121 306-313, 1998
DOI:10.1006/jsbi.1998.3968
Tskhovrebova L; Trinick J Direct visualization of extensibility in isolated titin molecules JOURNAL OF MOLECULAR BIOLOGY 265 100-106, 1997
DOI:10.1006/jmbi.1996.0717
Tskhovrebova L; Trinick J; Sleep JA; Simmons RM Elasticity and unfolding of single molecules of the giant muscle protein titin NATURE 387 308-312, 1997
DOI:10.1038/387308a0
Burgess SA; Walker ML; White HD; Trinick J Flexibility within myosin heads revealed by negative stain and single-particle analysis JOURNAL OF CELL BIOLOGY 139 675-681, 1997
DOI:10.1083/jcb.139.3.675
Hallett P; Tskhovrebova L; Trinick J; Offer G; Miles MJ Improvements in atomic force microscopy protocols for imaging fibrous proteins JOURNAL OF VACUUM SCIENCE&TECHNOLOGY B 14 1444-1448, 1996
DOI:10.1116/1.589116
Trinick J Titin as a scaffold and spring. Cytoskeleton. Curr Biol 6 258-260, 1996
Trinick J Interaction of titin/connectin with the thick filament ADVANCES IN BIOPHYSICS, VOL. 33, 1996 33 81-90, 1996
DOI:10.1016/S0065-227X(96)90024-6
Walker M; Trinick J; White H Millisecond time resolution electron cryo-microscopy of the M-ATP transient kinetic state of the acto-myosin ATPase. Biophys J 68 87S-91S, 1995
HOUMEIDA A; HOLT J; TSKHOVREBOVA L; TRINICK J STUDIES OF THE INTERACTION BETWEEN TITIN AND MYOSIN JOURNAL OF CELL BIOLOGY 131 1471-1481, 1995
DOI:10.1083/jcb.131.6.1471
TRINICK J TITIN AND NEBULIN - PROTEIN RULERS IN MUSCLE TRENDS IN BIOCHEMICAL SCIENCES 19 405-409, 1994
DOI:10.1016/0968-0004(94)90088-4
WALKER M; WHITE H; BELKNAP B; TRINICK J ELECTRON CRYOMICROSCOPY OF ACTO-MYOSIN-S1 DURING STEADY-STATE ATP HYDROLYSIS BIOPHYSICAL JOURNAL 66 1563-1572, 1994
SOTERIOU A; CLARKE A; MARTIN S; TRINICK J TITIN FOLDING ENERGY AND ELASTICITY PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 254 83-86, 1993
DOI:10.1098/rspb.1993.0130
SOTERIOU A; GAMAGE M; TRINICK J A SURVEY OF INTERACTIONS MADE BY THE GIANT PROTEIN TITIN JOURNAL OF CELL SCIENCE 104 119-123, 1993
LABEIT S; GAUTEL M; LAKEY A; TRINICK J TOWARDS A MOLECULAR UNDERSTANDING OF TITIN EMBO JOURNAL 11 1711-1716, 1992
Trinick J Molecular rulers in muscle? Current Biology 2 75-77, 1992
TRINICK J UNDERSTANDING THE FUNCTIONS OF TITIN AND NEBULIN FEBS LETTERS 307 44-48, 1992
DOI:10.1016/0014-5793(92)80899-R
Trinick J Elastic filaments and giant proteins in muscle Current Opinion in Cell Biology 3 112-119, 1991
WALKER M; KNIGHT P; TRINICK J PROPERTIES OF THE MYOSIN MOLECULE REVEALED BY NEGATIVE STAINING MICRON AND MICROSCOPICA ACTA 22 413-422, 1991
DOI:10.1016/0739-6260(91)90059-9
LABEIT S; GIBSON T; LAKEY A; LEONARD K; ZEVIANI M; KNIGHT P; WARDALE J; TRINICK J EVIDENCE THAT NEBULIN IS A PROTEIN-RULER IN MUSCLE THIN-FILAMENTS FEBS LETTERS 282 313-316, 1991
DOI:10.1016/0014-5793(91)80503-U
LABEIT S; BARLOW D; GAUTEL M; GIBSON T; HOLT J; HSIEH C; FRANCKE U; LEONARD K; WARDALE J; WHITING A; TRINICK J A REGULAR PATTERN OF 2 TYPES OF 100-RESIDUE MOTIF IN THE SEQUENCE OF TITIN NATURE 345 273-276, 1990
DOI:10.1038/345273a0
TRINICK J; COOPER J CONCENTRATION OF SOLUTES DURING PREPARATION OF AQUEOUS SUSPENSIONS FOR CRYOELECTRON MICROSCOPY JOURNAL OF MICROSCOPY 159 215-222, 1990
WALKER M; TRINICK J ELECTRON-MICROSCOPY OF NEGATIVELY STAINED SCALLOP MYOSIN MOLECULES - EFFECT OF REGULATORY LIGHT CHAIN REMOVAL ON HEAD STRUCTURE JOURNAL OF MOLECULAR BIOLOGY 208 469-475, 1989
DOI:10.1016/0022-2836(89)90510-X
WHITING A; WARDALE J; TRINICK J DOES TITIN REGULATE THE LENGTH OF MUSCLE THICK FILAMENTS JOURNAL OF MOLECULAR BIOLOGY 205 263-268, 1989
DOI:10.1016/0022-2836(89)90381-1
Offer G; Starr R; Trinick J Phosphofructokinase: a component of the thick filament? Advances in Experimental Medicine and Biology 226 61-73, 1988
WALKER M; TRINICK J VISUALIZATION OF DOMAINS IN NATIVE AND NUCLEOTIDE-TRAPPED MYOSIN HEADS BY NEGATIVE STAINING JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY 9 359-366, 1988
DOI:10.1007/BF01773879
TRINICK J; BERRIMAN J ZERO-LOSS ELECTRON-MICROSCOPY WITH THE ZEISS EM902 ULTRAMICROSCOPY 21 393-397, 1987
DOI:10.1016/0304-3991(87)90039-8
WALKER M; TRINICK J ELECTRON-MICROSCOPE STUDY OF THE EFFECT OF TEMPERATURE ON THE LENGTH OF THE TAIL OF THE MYOSIN MOLECULE JOURNAL OF MOLECULAR BIOLOGY 192 661-667, 1986
DOI:10.1016/0022-2836(86)90283-4
CRAIG R; TRINICK J; KNIGHT P DISCREPANCIES IN LENGTH OF MYOSIN HEAD NATURE 320 688-688, 1986
DOI:10.1038/320688b0
TRINICK J; COOPER J; SEYMOUR J; EGELMAN E CRYOELECTRON MICROSCOPY AND 3-DIMENSIONAL RECONSTRUCTION OF ACTIN-FILAMENTS JOURNAL OF MICROSCOPY-OXFORD 141 349-360, 1986
WALKER M; KNIGHT P; TRINICK J NEGATIVE STAINING OF MYOSIN MOLECULES JOURNAL OF MOLECULAR BIOLOGY 184 535-542, 1985
DOI:10.1016/0022-2836(85)90300-6
TRINICK J; KNIGHT P; WHITING A PURIFICATION AND PROPERTIES OF NATIVE TITIN JOURNAL OF MOLECULAR BIOLOGY 180 331-356, 1984
DOI:10.1016/S0022-2836(84)80007-8
KNIGHT P; TRINICK J STRUCTURE OF THE MYOSIN PROJECTIONS ON NATIVE THICK FILAMENTS FROM VERTEBRATE SKELETAL-MUSCLE JOURNAL OF MOLECULAR BIOLOGY 177 461-482, 1984
DOI:10.1016/0022-2836(84)90295-X
COOPER J; TRINICK J BINDING AND LOCATION OF AMP DEAMINASE IN RABBIT PSOAS MUSCLE MYOFIBRILS JOURNAL OF MOLECULAR BIOLOGY 177 137-152, 1984
DOI:10.1016/0022-2836(84)90061-5
OFFER G; TRINICK J A UNIFYING HYPOTHESIS FOR THE MECHANISM OF CHANGES IN THE WATER-HOLDING CAPACITY OF MEAT JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE 34 1018-1019, 1983
OFFER G; TRINICK J ON THE MECHANISM OF WATER HOLDING IN MEAT - THE SWELLING AND SHRINKING OF MYOFIBRILS MEAT SCIENCE 8 245-281, 1983
DOI:10.1016/0309-1740(83)90013-X
KNIGHT P; TRINICK J PREPARATION OF MYOFIBRILS METHODS IN ENZYMOLOGY 85 9-12, 1982
TRINICK J PREPARATION OF NATIVE THICK FILAMENTS METHODS IN ENZYMOLOGY 85 17-20, 1982
TRINICK J END-FILAMENTS - A NEW STRUCTURAL ELEMENT OF VERTEBRATE SKELETAL-MUSCLE THICK FILAMENTS JOURNAL OF MOLECULAR BIOLOGY 151 309-314, 1981
DOI:10.1016/0022-2836(81)90517-9
TRINICK J; COOPER J SEQUENTIAL DISASSEMBLY OF VERTEBRATE MUSCLE THICK FILAMENTS JOURNAL OF MOLECULAR BIOLOGY 141 315-321, 1980
DOI:10.1016/0022-2836(80)90183-7
TRINICK J; OFFER G CROSS-LINKING OF ACTIN-FILAMENTS BY HEAVY-MEROMYOSIN JOURNAL OF MOLECULAR BIOLOGY 133 549-556, 1979
DOI:10.1016/0022-2836(79)90407-8
Trinick JA; Lowey S M-protein from chicken pectoralis muscle J Mol Biol 113 343-368, 1977
