Multidisciplinary Cardiovascular Research Centre
Anthony Turner

Professor Anthony Turner

MA, PhD, Cambridge
Professor of Biochemistry
Institute of Molecular and Cellular Biology

Background: Postdoctoral work at Mario Negri Pharmacology Institute, Milan, Italy, 1972-1973; Lecturer in Biochemistry at Leeds, 1973; Senior Lecturer, 1982, Reader in Neurochemistry, 1987, Professor of Biochemistry, 1990, Head of School, 1996.

Office: Garstang 6.41a
Phone: +44(0) 113 34 33131
Email: a.j.turner@leeds.ac.uk 

Centre membership: Neuroscience Research at Leeds (NeuR@L)

You can read more about Professor Turner's interests here:
www.fbs.leeds.ac.uk/staff/Hooper_N

Figure 1: Structure of NEP complexed with its inhibitor, phosphoramidon

Figure 2: Amyloid plaque as formed in the brain of Alzheimer patients. The major component of the plaque, beta-amyloid peptide, is neurotoxic and contributes to the neurodegeneration process.

Research Interests

Membrane metalloproteases in health and disease

Proteinases play a key role in many aspects of cell regulation - from fertilisation and embryogenesis to death. The main focus of our research is understanding the molecular and cell biology of critical metalloproteinase targets in brain, cardiovascular system and reproductive tissue. A primary focus involves the neprilysin (NEP) family, which now numbers seven in humans but is over twenty in both C. elegans and Drosophila. We are using functional genomics approaches to understand the multiple roles of these NEP homologues in terminating neuropeptide signalling events in vertebrate and invertebrate organisms. In particular, we have projects in the areas of atherosclerosis, neurodegeneration and cancer. We have also recently cloned a novel human homologue (ACEH) of the blood pressure regulating peptidase, angiotensin converting enzyme (ACE). We are currently exploring the structure and physiological roles of ACEH and whether it might constitute a therapeutic target. A third topic area involves an understanding of the proteolytic events involved in the production and removal of the b-amyloid peptide, involved in Alzheimer's disease. Remarkably, NEP appears to play a key role in disposing of the toxic amyloid and therefore serves multiple protective roles in the body.

 

Current Projects

Work is supported by the Medical Research Council, BBSRC, British Heart Foundation, the Wellcome Trust, National Heart Research Fund, the Royal Society and by industry. Collaborations are in place with research groups in the United States, Japan, Russia, Australia and Europe.

 

Studentship information

Undergraduate project topics:

  • A novel angiotensin converting enzyme homologue: expression and characterisation
    Keywords: Expression, mutagenesis, membrane protein, enzymology, SDS-PAGE
    (Laboratory)
  • Regulation of peptidase expression in human disease
    Keywords: Immunocytochemistry, membrane protein, HPLC, expression, PCR
    (Laboratory)
  • The molecular basis of Parkinson's disease
    Keywords: Review and construct a grant application, media article or website to examine one aspect of the biochemistry of Parkinson's disease
    (Literature)

Postgraduate studentship areas:

  • Membrane Metalloproteases in Health and Disease: neurodegeneration, heart disease and cancer

See also:

Publications

Hong Y; Beckett C; Belyaev ND; Turner AJ The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells INTERNATIONAL JOURNAL OF CANCER 130 775-786, 2012
DOI:10.1002/ijc.26028

Nalivaeva NN; Belyaev ND; Lewis DI; Pickles AR; Makova NZ; Bagrova DI; Dubrovskaya NM; Plesneva SA; Zhuravin IA; Turner AJ Effect of Sodium Valproate Administration on Brain Neprilysin Expression and Memory in Rats JOURNAL OF MOLECULAR NEUROSCIENCE 46 569-577, 2012
DOI:10.1007/s12031-011-9644-x

Beckett C; Nalivaeva NN; Belyaev ND; Turner AJ Nuclear signalling by membrane protein intracellular domains: The AICD enigma CELLULAR SIGNALLING 24 402-409, 2012
DOI:10.1016/j.cellsig.2011.10.007

Clarke NE; Turner AJ Angiotensin-converting enzyme 2: the first decade. Int J Hypertens 2012 307315-, 2012
DOI:10.1155/2012/307315

Nalivaeva NN; Beckett C; Belyaev ND; Turner AJ Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? JOURNAL OF NEUROCHEMISTRY 120 167-185, 2012
DOI:10.1111/j.1471-4159.2011.07510.x

Checler F; Turner AJ Journal of Neurochemistry special issue on Alzheimer's disease: amyloid cascade hypothesis-20 years on Preface JOURNAL OF NEUROCHEMISTRY 120 CP9-CP10, 2012
DOI:10.1111/j.1471-4159.2011.07603.x

Rybnikova E; Gluschenko T; Galeeva A; Tulkova E; Nalivaeva NN; Makova NZ; Turner AJ; Samoilov M Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning NEUROSCIENCE RESEARCH 72 364-373, 2012
DOI:10.1016/j.neures.2011.12.010

Rybnikova E; Gluschenko T; Galeeva A; Tulkova E; Nalivaeva NN; Makova NZ; Turner AJ; Samoilov M Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning Neuroscience Research 72 364-373, 2012

Kamilic J; Hamming I; Lely AT; Korstanje R; Schulze U; Poppinga WJ; Turner AJ; Clarke NE; van Goor H; Navis GJ Rat Ace allele variation determines susceptibility to AngII-induced renal damage JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 12 420-429, 2011
DOI:10.1177/1470320311415886

Sonnino S; Prinetti A; Nalivaeva NN; Turner AJ The Fourth ISN Special Neurochemistry Conference - "Membrane domains in CNS Physiology and Pathology", Erice, Trapani, Sicily, 22-26 May 2010 PREFACE JOURNAL OF NEUROCHEMISTRY 116 669-670, 2011
DOI:10.1111/j.1471-4159.2011.07181.x

Turner AJ; Belyaev ND; Nalivaeva NN Mediator: the missing link in amyloid precursor protein nuclear signalling EMBO REPORTS 12 180-181, 2011
DOI:10.1038/embor.2011.25

Hicks D; John D; Makova NZ; Henderson Z; Nalivaeva NN; Turner AJ Membrane targeting, shedding and protein interactions of brain acetylcholinesterase JOURNAL OF NEUROCHEMISTRY 116 742-746, 2011
DOI:10.1111/j.1471-4159.2010.07032.x

Griffiths HH; Whitehouse IJ; Baybutt H; Brown D; Kellett KAB; Jackson CD; Turner AJ; Piccardo P; Manson JC; Hooper NM Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein JOURNAL OF BIOLOGICAL CHEMISTRY 286 33489-33500, 2011
DOI:10.1074/jbc.M111.278556

Hong Y; Macnab S; Lambert LA; Turner AJ; Whitehouse A; Usmani BA Herpesvirus saimiri-based endothelin-converting enzyme-1 shRNA expression decreases prostate cancer cell invasion and migration INTERNATIONAL JOURNAL OF CANCER 129 586-598, 2011
DOI:10.1002/ijc.25719

Standeven KF; Hess K; Carter AM; Rice GI; Cordell PA; Balmforth AJ; Lu B; Scott DJ; Turner AJ; Hooper NM; Grant PJ Neprilysin, obesity and the metabolic syndrome INTERNATIONAL JOURNAL OF OBESITY 35 1031-1040, 2011
DOI:10.1038/ijo.2010.227

Belyaev ND; Kellett KAB; Beckett C; Makova NZ; Revett TJ; Nalivaeva NN; Hooper NM; Turner AJ The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a beta-Secretase-dependent Pathway JOURNAL OF BIOLOGICAL CHEMISTRY 285 41443-41454, 2010
DOI:10.1074/jbc.M110.141390

Whyteside AR; Hinsley EE; Lambert LA; McDermott PJ; Turner AJ ECE-1 influences prostate cancer cell invasion via ET-1-mediated FAK phosphorylation and ET-1-independent mechanisms CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 88 850-854, 2010
DOI:10.1139/Y10-054

Hicks D; John D; Makova NZ; Henderson Z; Nalivaeva NN; Turner AJ Membrane targeting, shedding and protein interactions of brain acetylcholinesterase, 2010

Whitehouse IJ; Jackson C; Turner AJ; Hooper NM Prion Protein is Reduced in Aging and in Sporadic but not in Familial Alzheimer's Disease JOURNAL OF ALZHEIMERS DISEASE 22 1023-1031, 2010
DOI:10.3233/JAD-2010-101071

Dubrovskaya NM; Nalivaeva NN; Plesneva SA; Feponova AA; Turner AJ; Zhuravin IA Changes in the activity of amyloid-degrading metallopeptidases leads to disruption of memory in rats Neuroscience and Behavioral Physiology 40 975-980, 2010

Lambert DW; Clarke NE; Turner AJ Not just angiotensinases: new roles for the angiotensin-converting enzymes CELLULAR AND MOLECULAR LIFE SCIENCES 67 89-98, 2010
DOI:10.1007/s00018-009-0152-x

Henderson Z; Matto N; John D; Nalivaeva NN; Turner AJ Co-localization of PRiMA with acetylcholinesterase in cholinergic neurons of rat brain: An immunocytochemical study BRAIN RESEARCH 1344 34-42, 2010
DOI:10.1016/j.brainres.2010.05.022

Nalivaeva NN; Belyaev ND; Turner AJ Sodium valproate: an old drug with new roles TRENDS IN PHARMACOLOGICAL SCIENCES 30 509-514, 2009

Belyaev ND; Nalivaeva NN; Makova NZ; Turner AJ Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease EMBO REPORTS 10 94-100, 2009
DOI:10.1038/embor.2008.222

Taylor DR; Parkin ET; Cocklin SL; Ault JR; Ashcroft AE; Turner AJ; Hooper NM Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein JOURNAL OF BIOLOGICAL CHEMISTRY 284 22590-22600, 2009
DOI:10.1074/jbc.M109.032599

Nalivaeva NN; Dubrovskaya NM; Plesneva SA; Bagrova DI; Turner AJ; Zhuravin IA MODULATING EFFECTS OF AGEING AND HYPOXIA ON AMYLOID-DEGRADING ENZYMES AND MEMORY IN RATS, 2009

Babusikova E; Hatok J; Dobrota D; Turner AJ; Nalivaeva NN Processing of amyloid precursor protein after ischemia insult, 2009

Babusikova E; Nalivaeva NN; Hatok J; Dobrota D; Turner AJ Effect of global ischemia and advanced age on metabolism of amyloid precursor protein, 2009

van Goor H; Melenhorst WBWH; Turner AJ; Holgate ST Adamalysins in biology and disease JOURNAL OF PATHOLOGY 219 277-286, 2009
DOI:10.1002/path.2594

Dubrovskaya NM; Nalivaeva NN; Plesneva SA; Feponova AA; Turner AJ; Zhuravin IA Changes in the Activity of Amyloid-Degrading Metallopeptidases Leads to Disruption of Memory in Rats ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA 59 630-638, 2009

Hunt CE; Turner AJ Cell biology, regulation and inhibition of beta-secretase (BACE-1) FEBS JOURNAL 276 1845-1859, 2009
DOI:10.1111/j.1742-4658.2009.06929.x

Dobrota D; Babusikova E; Turner AJ; Nalivaeva NN ISCHEMIA-REPERFUSION INJURY AND PROCESSING OF AMYLOID PRECURSOR PROTEIN, 2009

Belyaev ND; Nalivaeva NN; Makova NZ; Turner AJ Reactivation of the neprilysin gene: possible implications in Alzheimer's disease, 2009

Bland ND; Robinson P; Thomas JE; Shirras AD; Turner AJ; Isaac RE Locomotor and geotactic behavior of Drosophila melanogaster over-expressing neprilysin 2 PEPTIDES 30 571-574, 2009
DOI:10.1016/j.peptides.2008.10.020

Turner AJ; Belyaev ND; Nalivaeva NN Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease, 2009

Nalivaeva NN; Dubrovskaya NM; Plesneva SA; Bagrova DI; Turner AJ; Zhuravin IA MODULATION OF THE EFFECTS OF AGEING AND HYPOXIA ON AMYLOID-DEGRADING ENZYMES AND MEMORY IN RATS, 2009

Nalivaeva NN; Belyaev ND; Makova N; Turner AJ REGULATION OF GENE EXPRESSION OF NEPRILYSIN, AN AMYLOID-DEGRADING ENZYME: IMPLICATION FOR ALZHEIMER'S DISEASE, 2009

Lambert DW; Hooper NM; Turner AJ Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system BIOCHEMICAL PHARMACOLOGY 75 781-786, 2008
DOI:10.1016/j.bcp.2007.08.012

Bland ND; Pinney JW; Thomas JE; Turner AJ; Isaac RE Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships BMC EVOLUTIONARY BIOLOGY 8 -, 2008
DOI:10.1186/1471-2148-8-16

Hooper NM; Turner AJ A new take on prians: preventing Alzheimer's disease TRENDS IN BIOCHEMICAL SCIENCES 33 151-155, 2008
DOI:10.1016/j.tibs.2008.01.004

Rushworth CA; Guy JL; Turner AJ Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis FEBS JOURNAL 275 6033-6042, 2008
DOI:10.1111/j.1742-4658.2008.06733.x

Zhuravin IA; Dubrovskaya NM; Nalivaeva NN; Turner AJ Prenatal hypoxia affects amyloid metabolism and formation of cognitive functions in postnatal ontogenesis of rats, 2008
DOI:10.1016/j.ijpsycho.2008.05.395

Nalivaeva NN; Fisk LR; Belyaev ND; Turner AJ Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease CURRENT ALZHEIMER RESEARCH 5 212-224, 2008
DOI:10.2174/156720508783954785

Turner AJ Angiotensin-Converting Enzyme 2 Cardioprotective Player in the Renin-Angiotensin System? HYPERTENSION 52 816-817, 2008
DOI:10.1161/HYPERTENSIONAHA.108.116137

Bland ND; Pinney JW; Thomas JE; Turner AJ; Isaac RE Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships BMC Evolutionary Biology 8 -, 2008

Guy JL; Lambert DW; Turner AJ; Porter KE Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts EXPERIMENTAL PHYSIOLOGY 93 579-588, 2008
DOI:10.1113/expphysiol.2007.040139

Whyteside AR; Turner AJ Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences FEBS LETTERS 582 2382-2386, 2008
DOI:10.1016/j.febslet.2008.05.046

Kozina LS; Kochkina EG; Nalivaeva NN; Belyaev ND; Turner AJ; Arutjunyan AV The effects of vilon and epithalon peptides on the expression of neprilysin and insulin-degrading enzyme in human neuroblastoma NB7 cells under normal and hypoxic conditions NEUROCHEMICAL JOURNAL 2 69-71, 2008
DOI:10.1134/S1819712408010133

Lambert DW; Clarke NE; Hooper NM; Turner AJ Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain FEBS LETTERS 582 385-390, 2008
DOI:10.1016/j.febslet.2007.11.085

La Corte AIC; Carter AM; Turner AJ; Grant PJ; Hooper NM The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 9 221-225, 2008
DOI:10.1177/1470320308096405

Carter AM; Rice GI; Standeven KF; Scott DJ; Turner AJ; Hooper NM; Grant PJ Circulating neprilysin and cardiovascular risk: Associations with insulin resistance and the metabolic syndrome, 2008

Hamming I; van Goor H; Turner AJ; Rushworth CA; Michaud AA; Corvol P; Navis G Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats EXPERIMENTAL PHYSIOLOGY 93 631-638, 2008
DOI:10.1113/expphysiol.2007.041855

Lambert LA; Whyteside AR; Turner AJ; Usmani BA Isoforms of endothelin-converting enzyme-1 (ECE-1) have opposing effects on prostate cancer cell invasion BRITISH JOURNAL OF CANCER 99 1114-1120, 2008
DOI:10.1038/sj.bjc.6604631

Nalivaeva NN; Fisk L; Kochkina EG; Makova N; Belyaev ND; Zhuravin IA; Turner AJ Modulation of expression of amyloid-degrading enzymes in ageing brain and in human neuroblastoma cells as a target for AD therapy, 2007

Fisk L; Nalivaeva NN; Boyle JP; Peers CS; Turner AJ Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes NEUROCHEMICAL RESEARCH 32 1741-1748, 2007
DOI:10.1007/s11064-007-9349-2

Parkin ET; Watt NT; Hussain I; Eckman EA; Eckman CB; Manson JC; Baybutt HN; Turner AJ; Hooper NM Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104 11062-11067, 2007
DOI:10.1073/pnas.0609621104

Nalivaeva NN; Makova N; Kochkina EG; John D; Belyaev ND; Kozina LS; Arutjunyan AV; Turner AJ Protective effect of the peptides vilon and epithalon against hypoxia induced changes in amyloid-degrading enzymes, 2007

Dobrota D; Babusikova E; Nalivaeva NN; Turner AJ Effect of ischemia and reperfusion on processing of the amyloid precursor protein, 2007

Turner AJ; Nalivaeva NN New insights into the roles of metalloproteinases in neurodegeneration and neuroprotection NEUROINFLAMMATION IN NEURONAL DEATH AND REPAIR 82 113-135, 2007
DOI:10.1016/S0074-7742(07)82006-X

Bland ND; Thomas JE; Audsley N; Shirras AD; Turner AJ; Isaac RE Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster PEPTIDES 28 127-135, 2007
DOI:10.1016/j.peptides.2006.08.032

Rella M; Elliot JL; Revett TJ; Lanfear J; Phelan A; Jackson RM; Turner AJ; Hooper NM Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE BMC GENOMICS 8 -, 2007
DOI:10.1186/1471-2164-8-194

Hamming I; Cooper ME; Haagmans BL; Hooper NM; Korstanje R; Osterhaus ADME; Timens W; Turner AJ; Navis G; van Goor H The emerging role of ACE2 in physiology and disease JOURNAL OF PATHOLOGY 212 1-11, 2007
DOI:10.1002/path.2162

Dobrota D; Babusikova E; Nalivaeva NN; Turner AJ Processing of amyloid precursor protein after ischemia insult, 2007

Nalivaeva NN; Plesneva SA; Kochkina EG; Zhuravin IA; Rybnikova EA; Galeeva AY; Samoilov MO; Turner AJ Effect of acute hypoxia and preconditioning to hypoxia on cholinesterase activity and amyloid metabolism in rat brain, 2006

Turner AJ; Sims C; Cordy JM; Thornhill P; Fisk L; Nalivaeva NN Dynamics of amyloid metabolism: the role of cholesterol, lipid rafts and hypoxia in amyloidogenesis, 2006

Jackson CD; Barnes K; Homer-Vanniasinkam S; Turner AJ Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein EXPERIMENTAL BIOLOGY AND MEDICINE 231 794-801, 2006

Cordy JM; Hooper NM; Turner AJ The involvement of lipid rafts in Alzheimer's disease (Review) MOLECULAR MEMBRANE BIOLOGY 23 111-122, 2006
DOI:10.1080/09687860500496417

Rice GI; Jones AL; Grant PJ; Carter AM; Turner AJ; Hooper NM Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study Hypertension 48 914-920, 2006

Rice GI; Jones AL; Grant PJ; Carter AM; Turner AJ; Hooper NM Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study HYPERTENSION 48 914-920, 2006
DOI:10.1161/01.HYP.0000244543.91937.79

Turner AJ; Nalivaeva NN Proteinase dysbalance in pathology: The neprilysin (NEP) and angiotensin-converting enzyme (ACE) families CELLULAR AND MOLECULAR BIOLOGY 52 40-48, 2006
DOI:10.1170/T725

Hunter AR; Turner AJ Expression and localization of endothelin-converting enzyme-1 isoforms in human endothelial cells EXPERIMENTAL BIOLOGY AND MEDICINE 231 718-722, 2006

Awano S; Dawson LA; Hunter AR; Turner AJ; Usmani BA Endothelin system in oral squamous carcinoma cells: Specific siRNA targeting of ECE-1 blocks cell proliferation INTERNATIONAL JOURNAL OF CANCER 118 1645-1652, 2006
DOI:10.1002/ijc.21525

Dawson LA; Maitland NJ; Berry P; Turner AJ; Usmani BA Expression and localization of endothelin-converting enzyme-1 in human prostate cancer EXPERIMENTAL BIOLOGY AND MEDICINE 231 1106-1110, 2006

Rella M; Rushworth CA; Guy JL; Turner AJ; Langer T; Jackson RM Structure-based pharmacophore design and virtual screening for novel angiotensin converting enzyme 2 inhibitors JOURNAL OF CHEMICAL INFORMATION AND MODELING 46 708-716, 2006
DOI:10.1021/ci0503614

Dubrovskaya NM; Nalivaeva NN; Turner AJ; Zhuravin IA Effects of an inhibitor ofα-secretase, which metabolizes the amyloid peptide precursor, on memory formation in rats Neuroscience and Behavioral Physiology 36 911-913, 2006

Fisk L; Nalivaeva NN; Turner AJ Regulation of endothelin-converting enzyme-1 expression in human neuroblastoma cells EXPERIMENTAL BIOLOGY AND MEDICINE 231 1048-1053, 2006

Nalivaeva NN; Fisk L; Kochkina EG; Makova N; Turner AJ Different mechanisms of secretion of amylold-degrading enzymes neprilysin and insulinase by human neuroblastoma cells in culture, 2006

Huovila APJ; Turner AJ; Pelto-Huikko M; Karkkainen L; Ortiz RM Shedding light on ADAM metalloproteinases TRENDS IN BIOCHEMICAL SCIENCES 30 413-422, 2005
DOI:10.1016/j.tibs.2005.05.006

Lambert DW; Yarski M; Warner FJ; Thornhill P; Parkin ET; Smith AI; Hooper NM; Turner AJ Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2) JOURNAL OF BIOLOGICAL CHEMISTRY 280 30113-30119, 2005
DOI:10.1074/jbc.M505111200

Warner FJ; Lew RA; Smith IA; Lambert DW; Hooper NM; Turner AJ Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells JOURNAL OF BIOLOGICAL CHEMISTRY 280 39353-39362, 2005
DOI:10.1074/jbc.M508914200

Leisle L; Parkin ET; Turner AJ; Hooper NM Angiotensin-converting enzyme as a GPIase: a critical reevaluation NATURE MEDICINE 11 1139-1140, 2005
DOI:10.1038/nm1105-1139

Thomas JE; Rylett CM; Carhan A; Bland ND; Bingham RJ; Shirras AD; Turner AJ; Isaac RE Drosophila melanogaster NEP2 is a new soluble member of the neprilysin family of endopeptidases with implications for reproduction and renal function BIOCHEMICAL JOURNAL 386 357-366, 2005
DOI:10.1042/BJ20041753

Dubrovskaya NM; Nalivaeva NN; Turner AJ; Zhuravin IA Effect of an inhibitor of alpha-secretase metabolizing amyloid precursor protein on memory in rats ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA 55 725-728, 2005

Guy JL; Jackson RM; Jensen HA; Hooper NM; Turner AJ Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis FEBS JOURNAL 272 3512-3520, 2005
DOI:10.1111/j.1742-4658.2005.04756.x

Guy JL; Lambert DW; Wamer FJ; Hooper NM; Turner AJ Membrane-associated zinc peptidase families: comparing ACE and ACE2 BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1751 2-8, 2005
DOI:10.1016/j.bbapap.2004.10.010

Dawson LA; Maitland NJ; Turner AJ; Usmani BA; Loberg RD; Pienta KJ Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression Urologic Oncology: Seminars and Original Investigations 23 73-74, 2005

Nalivaeva NN; Fisk L; Makova N; Zhuravin IA; Dubrovskaya NM; Babusikova E; Dobrota D; Rybnikova EA; Samoilov MO; Turner AJ Effects of hypoxia and ischaemia on amyloid-degrading enzymes, 2005

Semenza G; Turner AJ Preface to volume 43 Comprehensive Biochemistry 43 v-vi, 2004

Dawson LA; Maitland NJ; Turner AJ; Usmani BA Stromal-epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expression BRITISH JOURNAL OF CANCER 90 1577-1582, 2004
DOI:10.1038/sj.bjc.6601717

Nalivaeva NN; Fisk L; Kochkina EG; Plesneva SA; Zhuravin IA; Babusikova E; Dobrota D; Turner AJ Effect of hypoxia/ischemia and hypoxic preconditioning/reperfusion on expression of some amyloid-degrading enzymes PROTECTIVE STRATEGIES FOR NEURODEGENERATIVE DISEASES 1035 21-33, 2004
DOI:10.1196/annals.1332.002

Leah E; Turner AJ; Usmani BA Analysis of NEP and ECE-1 metalloproteinase expression in prostate cancer tissue microarrays, 2004

Semenza G; Turner AJ Comprehensive Biochemistry, 2004

Parkin ET; Watt NT; Turner AJ; Hooper NM Dual mechanisms for shedding of the cellular prion protein JOURNAL OF BIOLOGICAL CHEMISTRY 279 11170-11178, 2004
DOI:10.1074/jbc.M312105200

Turner AJ; Fisk L; Nalivaeva NN Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration PROTECTIVE STRATEGIES FOR NEURODEGENERATIVE DISEASES 1035 1-20, 2004
DOI:10.1196/annals.1332.001

Turner AJ; Hiscox JA; Hooper NM ACE2: from vasopeptidase to SARS virus receptor TRENDS IN PHARMACOLOGICAL SCIENCES 25 291-294, 2004
DOI:10.1016/j.tips.2004.04.001

Parkin ET; Turner AJ; Hooper NM Secretase-mediated cell surface shedding of the angiotensin-converting enzyme PROTEIN AND PEPTIDE LETTERS 11 423-432, 2004
DOI:10.2174/0929866043406544

Allinson TMJ; Parkin ET; Condon TP; Schwager SLU; Sturrock ED; Turner AJ; Hooper NM The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein EUROPEAN JOURNAL OF BIOCHEMISTRY 271 2539-2547, 2004
DOI:10.1111/j.1432-1033.2004.04184.x

Smith AI; Turner AJ What's new in the renin-angiotensin system? CELLULAR AND MOLECULAR LIFE SCIENCES 61 2675-2676, 2004
DOI:10.1007/s00018-004-4319-1

Warner FJ; Smith AI; Hooper NM; Turner AJ Angiotensin-converting enzyme-2: a molecular and cellular perspective CELLULAR AND MOLECULAR LIFE SCIENCES 61 2704-2713, 2004
DOI:10.1007/s00018-004-4240-7

Keynan S; Khamaisi M; Dahan R; Barnes K; Jackson CD; Turner AJ; Raz I Increased expression of endothelin-converting enzyme-1c isoform in response to high glucose levels in endothelial cells JOURNAL OF VASCULAR RESEARCH 41 131-140, 2004
DOI:10.1159/000077132

Howell GJ; Herbert SP; Smith JM; Mittar S; Ewan LC; Mohammed M; Hunter AR; Simpson N; Turner AJ; Zachary I; Walker JH; Ponnambalam S Endothelial cell confluence regulates Weibel-Palade body formation MOLECULAR MEMBRANE BIOLOGY 21 413-421, 2004
DOI:10.1080/09687860400011571

Howell GJ; Herbert SP; Smith JM; Mittar S; Ewan LC; Mohammed M; Hunter AR; Simpson NAB; Turner AJ; Zachary I; Walker JH; Ponnambalam S Endothelial cell confluence regulates Weibel-Palade body formation Molecular Membrane Biology 21 413-421, 2004
DOI:10.1080/09687860400011571

Rice GI; Thomas DA; Grant PJ; Turner AJ; Hooper NM Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism BIOCHEMICAL JOURNAL 383 45-51, 2004
DOI:10.1042/BJ20040634

Allinson TMJ; Parkin ET; Turner AJ; Hooper NM ADAMs family members as amyloid precursor protein alpha-secretases JOURNAL OF NEUROSCIENCE RESEARCH 74 342-352, 2003
DOI:10.1002/jnr.10737

Dawson LA; Maitland NJ; Turner AJ; Usmani BA NEP and ECE can modulate stromal-epithelial interactions and can influence invasive behaviour of prostate cancer cells, 2003

Hooper NM; Turner AJ An ACE structure NATURE STRUCTURAL BIOLOGY 10 155-157, 2003
DOI:10.1038/nsb0303-155

Parkin ET; Tan F; Skidgel RA; Turner AJ; Hooper NM The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts JOURNAL OF CELL SCIENCE 116 3079-3087, 2003
DOI:10.1242/jcs.00626

Nalivaeva NN; Fisk L; Aviles RMC; Plesneva SA; Zhuravin IA; Turner AJ Effects of prenatal hypoxia on expression of amyloid precursor protein and metallopeptidases in the rat brain, 2003
DOI:10.1007/BF02442577

Warner FJ; Guy JL; Lambert DW; Hooper NM; Turner AJ Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function, 2003
DOI:10.1007/BF02442567

Dawson LA; Maitland NJ; Turner AJ; Usmani BA NEP and ECE can modulate stromal-epithelial interactions and can influence invasive behaviour of prostate cancer cells, 2003

Nalivaeva NN; Carson JA; Fisk L; Turner AJ Zinc peptidases and Alzheimer's disease, 2003
DOI:10.1046/j.1471-4159.85.s2.16_9.x

Nalivaeva NN; Carson JA; Fisk L; Turner AJ Zinc peptidases and Alzheimer's disease Journal of Neurochemistry 85 pp.21-, 2003
DOI:10.1046/j.1471-4159.85.s2.16_9.x

Turner AJ Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries BIOCHEMICAL SOCIETY TRANSACTIONS 31 723-727, 2003
DOI:10.1042/BST0310723

Nalivaeva NN; Fisk L; Kochkina EG; Plesneva SA; Dubrovskaya NM; Zhuravin IA; Turner AJ Effect of hypoxia on cholinesterases in the developing brain, 2003

Cordy JM; Hussain I; Dingwall C; Hooper NM; Turner AJ Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100 11735-11740, 2003
DOI:10.1073/pnas.1635130100

Guy JL; Jackson RM; Acharya KR; Sturrock ED; Hooper NM; Turner AJ Angiotensin-converting enzyme-2 (ACE2): Comparative modeling of the active site, specificity requirements, and chloride dependence BIOCHEMISTRY 42 13185-13192, 2003
DOI:10.1021/bi035268s

Turner AJ Exploring the structure and function of zinc metallopeptidases: old enzymes and new discoveries. Biochem Soc Trans 31 723-727, 2003

Semenza G; Turner AJ Preface to volume 42 Comprehensive Biochemistry 42 v-vii, 2003

Carson JA; Turner AJ β-amyloid catabolism: Roles for neprilysin (NEP) and other metallopeptidases? Journal of Neurochemistry 81 1-8, 2002

Carson JA; Ansai T; Awano S; Yu WX; Takehara T; Turner AJ Characterization of PgPepO, a bacterial homologue of endothelin-coverting enzyme-1, 2002

Usmani BA; Harden B; Maitland NJ; Turner AJ Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines CLINICAL SCIENCE 103 314S-317S, 2002

Parkin ET; Trew A; Christie G; Faller A; Mayer R; Turner AJ; Hooper NM Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha BIOCHEMISTRY 41 4972-4981, 2002
DOI:10.1021/bi015936e

Ansai T; Yamamoto E; Awano S; Yu WX; Turner AJ; Takehara T Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis CLINICAL SCIENCE 103 327S-331S, 2002

Nalivaeva NN; Plesneva SA; Zhuravin IA; Dubrovskaya NM; Kochkina EG; Canet-Aviles RM; Turner AJ Effects of prenatal hypoxia on soluble form of AChE and processing of APP Journal of Neurochemistry 78 pp.69-, 2002

Carson JA; Turner AJ beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases? JOURNAL OF NEUROCHEMISTRY 81 1-8, 2002
DOI:10.1046/j.1471-4159.2002.00855.x

Canet-Aviles RM; Anderton M; Hooper NM; Turner AJ; Vaughan PFT Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C-alpha, src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C MOLECULAR BRAIN RESEARCH 102 62-72, 2002
DOI:10.1016/S0169-328X(02)00184-5

Turner AJ; Hooper NM The angiotensin-converting enzyme gene family: genomics and pharmacology TRENDS IN PHARMACOLOGICAL SCIENCES 23 177-183, 2002
DOI:10.1016/S0165-6147(00)01994-5

Nalivaeva NN; Canet-Aviles RM; Plesneva SA; Kochkina EG; Dubrovskaya NM; Zhuravin IA; Turner AJ Developmental profile of different forms of AChE in various structures of rat brain after prenatal hypoxia The FASEB Journal 16 816-816, 2002

Jackson CD; Turner AJ Detection and assessment of endothelin-converting enzyme activity. Methods in molecular biology (Clifton, N.J.) 206 107-124, 2002

Nalivaeva NN; Aviles RMC; Plesneva SA; Kochkina EG; Dubrovskaya NM; Zhuravin IA; Turner AJ Developmental profile of different forms of AChE in various structures of rat brain after prenatal hypoxia. FASEB JOURNAL 16 A816-A816, 2002

Park SW; Choi K; Lee HB; Park SK; Turner AJ; Hooper NM; Park HS Glycosyl-phosphatidytinositol (GPI)-anchored renal dipeptidase is released by a phospholipase C in vivo KIDNEY&BLOOD PRESSURE RESEARCH 25 7-12, 2002
DOI:10.1159/000049429

Hooper NM; Turner AJ The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer's disease CURRENT MEDICINAL CHEMISTRY 9 1107-1119, 2002

Carson JA; Ansai T; Awano S; Yu WX; Takehara T; Turner AJ Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1, 2002

Dawson LA; Maitland NJ; Turner AJ; Usmani BA The influence of NEP/ECE metalloproteinase expression on stromal-epithelial interactions in prostate cancer BRITISH JOURNAL OF CANCER 86 S86-S86, 2002

Nalivaeva NN; Canet-Aviles RM; Plesneva SA; Zhuravin IA; Turner AJ Effect of prenatal hypoxia on amyloid precursor protein (APP) expression and processing in the cortex and striatum of rats Acta Physiologica Hungarica 89 pp.190-, 2002

Guy JL; Warner FJ; Turner AJ Characterisation and localisation of an angiotensin-converting enzyme homologue The FASEB Journal 16 1194-1194, 2002

Guy JL; Warner FJ; Turner AJ Characterisation and localisation of an angiotensin-converting enzyme homologue FASEB JOURNAL 16 A1194-A1194, 2002

Arimoto T; Ansai T; Yu WX; Turner AJ; Takehara T Kinetic analysis of PPi-dependent phosphofructokinase from Porphyromonas gingivalis FEMS MICROBIOLOGY LETTERS 207 35-38, 2002
DOI:10.1111/j.1574-6968.2002.tb11024.x

Turner AJ; Tipnis SR; Guy JL; Rice GI; Hooper NM ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 80 346-353, 2002
DOI:10.1139/Y02-021

Dawson LA; Maitland NJ; Turner AJ; Usmani BA The influence of NEP/ECE metalloproteinase expression on stromal-epithelial interactions in prostate cancer British Journal of Cancer 86 86-86, 2002

Canet-Aviles RM; Turner AJ; Hooper NM; Vaughan PFT Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C alpha, SRC-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C NEUROBIOLOGY OF AGING 23 S527-S527, 2002

Mizutani S; Turner AJ Cell-surface aminopeptidases: basic and clinical aspects, 2001

Nalivaeva NN; Zhuravin IA; Plesneva SA; Dubrovskaya NM; Turner AJ Effect of prenatal hypoxia on the soluble form of AChE in the cortex and striatum of rats, 2001

Nalivaeva NN; Plesneva SA; Dubrovskaya NM; Zhuravin IA; Turner AJ Effect of prenatal hypoxia on developmental profile of APP processing in the cortex and striatum of rats Journal of Molecular Neuroscience 16 pp.62-, 2001

Nalivaeva NN; Plesneva SA; Dubrovskaya NM; Zhuravin IA; Turner AJ Neurodegenerative effect of hypoxia on developing brain Journal of Neurochemistry 76 pp.40-, 2001

Nalivaeva NN; Zhuravin IA; Plesneva SA; Dubrovskaya NM; Turner AJ Effects of prenatal hypoxia on the soluble form of AChE in the cortex and striatum of rats. Proceedings of the meeting of British Neuroscience Association, Harrogate, April 2001., 2001

Nalivaeva NN; Plesneva SA; Dubrovskaya NM; Zhuravin IA; Turner AJ Soluble acetylcholinesterase: Possible mechanism of secretion and physiological significance FASEB JOURNAL 15 A427-A427, 2001

Nalivaeva NN; Plesneva SA; Zhuravin IA; Dubrovskaya NM; Kochkina EG; Canet RM; Turner AJ Effects of prenatal hypoxia on soluble form of AChE and processing of APP JOURNAL OF NEUROCHEMISTRY 78 69-69, 2001

Nalivaeva NN; Turner AJ Post-translational modifications of proteins: Acetylcholinesterase as a model system PROTEOMICS 1 735-747, 2001
DOI:10.1002/1615-9861(200106)1:6<735::aid-prot735>3.3.CO;2-#

Nalivaeva NN; Plesneva SA; Dubrovskaya NM; Zhuravin IA; Turner AJ Effects of prenatal hypoxia on developmental profile of APP processing in the cortex and striatum of rats Journal of Molecular Neuroscience 16 pp.62-, 2001

Turner AJ Cell-surface peptidases in health and disease: old enzymes and new developments, 2001

Nalivaeva NN; Plesneva SA; Dubrovskaya NM; Zhuravin IA; Turner AJ Neurodegenerative effect of hypoxia on developing brain JOURNAL OF NEUROCHEMISTRY 77 40-40, 2001

Alfalah M; Parkin ET; Jacob R; Sturrock ED; Mentele R; Turner AJ; Hooper NM; Naim HY A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase JOURNAL OF BIOLOGICAL CHEMISTRY 276 21105-21109, 2001
DOI:10.1074/jbc.M100339200

Turner AJ; Isaac RE; Coates D The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function BIOESSAYS 23 261-269, 2001
DOI:10.1002/1521-1878(200103)23:3<261::aid-bies1036>3.0.CO;2-K

Turner AJ Functional genomic approaches to peptide processing events Journal of Molecular Neuroscience 16 pp.62-, 2001

Tipnis SR; Hooper NM; Christie G; Turner AJ Identification and characterisation of ACEH, a human homolog of angiotensin-converting enzyme, 2001

Tipnis SR; Hooper NM; Christie G; Turner AJ Identification and characterization of ACEH, a human homolog of angiotensin converting enzyme, 2001

Parkin ET; Turner AJ; Hooper NM Differential effects of glycosphingolipids on the detergent-insolubility of the glycosylphosphatidylinositol-anchored membrane dipeptidase BIOCHEMICAL JOURNAL 358 209-216, 2001
DOI:10.1042/0264-6021:3580209

Nalivaeva NN; Plesneva SA; Dubrovskaya NM; Zhuravin IA; Turner AJ Soluble acetylcholinesterase: Possible mechanism of secretion and physiological significance The FASEB Journal 15 pp.427-, 2001

Usmani BS; Maitland NJ; Nanus DM; Turner AJ Differential expression of ECE and NEP metalloproteinase in prostate cancer BRITISH JOURNAL OF CANCER 85 87-87, 2001

Tipnis SR; Hooper NM; Hyde R; Karran E; Christie G; Turner AJ A human homolog of angiotensin-converting enzyme - Cloning and functional expression as a captopril-insensitive carboxypeptidase JOURNAL OF BIOLOGICAL CHEMISTRY 275 33238-33243, 2000
DOI:10.1074/jbc.M002615200

Turner AJ; Brown C; Carson JA; Barnes K The neprilysin family in health and disease In Cellular Peptidases in Immune Functions and Diseases 2 , 2000

Cottrell GS; Hyde RJ; Lim J; Parsons MR; Hooper NM; Turner AJ Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P BIOCHEMISTRY 39 15129-15135, 2000
DOI:10.1021/bi0015865

Brown C; Barnes K; Turner AJ Functional significance of the isoforms of endothelin-converting enzyme-1 Journal of Cardiovascular Pharmacology 36 26-27, 2000

Keynan S; Dahan R; Wexler ID; Barnes K; Brown C; Turner AJ; Raz I The expression of the endothelin system in endothelial cells under hyperglycemic conditions DIABETOLOGIA 43 pp.132-, 2000

Cottrell GS; Hooper NM; Turner AJ Cloning, expression, and characterization of human cytosolic aminopeptidase P: A single manganese(II)-dependent enzyme BIOCHEMISTRY 39 15121-15128, 2000
DOI:10.1021/bi001585c

Hooper NM; Turner AJ Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease BIOCHEMICAL SOCIETY TRANSACTIONS 28 441-446, 2000
DOI:10.1042/0300-5127:0280441

Nalivaeva NN; Turner AJ Involvement of the cholinergic system and a metalloprotease in secretion of acetylcholinesterase Regulatory peptides 94 pp.40-, 2000

Hooper NM; Trew AJ; Parkin ET; Turner AJ The role of proteolysis in Alzheimer's disease CELLULAR PEPTIDASES IN IMMUNE FUNCTIONS AND DISEASES 2 477 379-390, 2000

Parkin ET; Turner AJ; Hooper NM Caveolae-like membranes and the amyloid precursor protein: a critical reassessment British Neurosci. Assoc. Abstr. 15 pp.59-, 1999

Barnes K; Turner AJ Endothelin converting enzyme is located on alpha-actin filaments in smooth muscle cells Cardiovascular Research 42 814-822, 1999

Turner AJ; Hooper NM Role for ADAM-family proteinases as membrane protein secretases BIOCHEMICAL SOCIETY TRANSACTIONS 27 255-259, 1999

Parkin ET; Turner AJ; Hooper NM Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein BIOCHEMICAL JOURNAL 344 23-30, 1999
DOI:10.1042/0264-6021:3440023

Parkin ET; Hussain I; Karran EH; Turner AJ; Hooper NM Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins JOURNAL OF NEUROCHEMISTRY 72 1534-1543, 1999
DOI:10.1046/j.1471-4159.1999.721534.x

Turner AJ; Brown C; Carson JA; Barnes K Endothelin-converting enzyme (ECE): more than a processing enzyme SEB Annual Meeting, Abstract Book: Animal and Cell Biology pp.58-, 1999

Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells BIOCHEMISTRY 38 9728-9734, 1999
DOI:10.1021/bi9906827

Nalivaeva NN; Turner AJ Study of acetylcholinesterase secretion by human neuroblastoma SH-SY5Y cells 30th Annual ASN Meeting, Journal of Neurochemistry 72 pp.23-, 1999

Hooper NM; Parvathy S; Karran EH; Turner AJ Angiotensin-converting enzyme and the amyloid precursor protein secretases BIOCHEMICAL SOCIETY TRANSACTIONS 27 229-234, 1999

Nalivaeva NN; Turner AJ Does acetylcholinesterase secretion involve an ADAMS-like metallosecretase? Letters in Peptide Science 6 343-348, 1999

Awano S; Ansai T; Mochizuki H; Yu WX; Tanzawa K; Turner AJ; Takehara T Sequencing, expression and biochemical characterization of the Porphyromonas gingivalis pepO gene encoding a protein homologous to human endothelin-converting enzyme FEBS Letters 460 139-144, 1999

Young T; Karran EH; Turner AJ; Hooper NM Expression and processing of the human beta-amyloid precursor protein in yeast British Neurosci. Assoc. Abstr. 15 pp.60-, 1999

Cottrell GS; Hyde RJ; Hooper NM; Turner AJ The cloning and functional expression of human pancreatic aminopeptidase P Biochemical Society Transactions 26 -, 1998

Barnes K; Walkden BJ; Kime L; Turner AJ Localization and regulation of the isoforms of brain endothelin converting enzyme-1 ESN/ISN Meeting, JOURNAL OF NEUROCHEMISTRY 71 pp.43-, 1998

Brown C; Barnes K; Turner AJ Anti-peptide antibodies specific to rat endothelin-converting enzyme-1 isoforms reveal isoform localisation and expression FEBS Letters 424 183-187, 1998

Parkin ET; Turner AJ; Hooper NM Detergent solubility and processing of the familial Alzheimer's disease-related presenilin proteins. BIOCHEMICAL SOCIETY TRANSACTIONS 26 S241-S241, 1998

Turner AJ; Stephenson FA Amino acid neurotransmission, 1998

Sansom CE; Hoang MV; Turner AJ Molecular modelling and site-durected mutagenesis of the active site of endothelin converting enzyme Protein Engineering 11 1235-1241, 1998

Parkin ET; Hooper NM; Turner AJ Presenilin proteins are present in calveolae-like, detergent-insoluble membranes which are devoid of the amyloid precursor protein Neurobiology of Ageing 19 pp.188-, 1998

Parvathy S; Karran EH; Turner AJ; Hooper NM The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase FEBS LETTERS 431 63-65, 1998
DOI:10.1016/S0014-5793(98)00726-1

Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: Similarities to the angiotensin converting enzyme secretase BIOCHEMISTRY 37 1680-1685, 1998
DOI:10.1021/bi972034y

Moore W; Karran EH; Hooper NM; Turner AJ Development of betaAPP695 constructs for cell free assay for the secretases involved in the proteolytic processing of the amyloid precursor protein Neurobiology of Ageing 19 pp.39-, 1998

Barnes K; Brown C; Turner AJ Endothelin-converting enzyme: Ultrastructural localization and its recycling from the cell surface Hypertension 31 3-9, 1998

Houldsworth S; Trew AJ; Hooper NM; Turner AJ Molecular characterisation of the Alzheimer's amyloid precursor protein secretases Meeting of the Biochemical Society, BIOCHEMICAL SOCIETY TRANSACTIONS 26 pp.245-, 1998

Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM Alzheimer's amyloid precursor proteinα-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: Similarities to the angiotensin converting enzyme secretase Biochemistry 37 1680-1685, 1998

Turner AJ; Barnes K; Schweizer A; Valdenaire O Isoforms of endothelin converting enzyme why and where? Trends in Pharmacological Sciences 19 483-486, 1998

Parvathy S; Hussain I; Karran EH; Turner AJ; Hooper NM The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by Meeting of the Biochemical Society, BIOCHEMICAL SOCIETY TRANSACTIONS 26 pp.247-, 1998

Houldsworth S; Trew AJ; Hooper NM; Turner AJ Angiotensin converting enzyme as a reporter protein for amyloid precursor protein secretase activities Neurobiology of Ageing 19 pp.39-, 1998

Hooper NM; Parvathy S; Hussain I; Turner AJ Inhibition of the amyloid precursor protein alpha-secretase at the cell-surface by hydroxamate-based zinc metalloprotease inhibitors Neurobiology of Ageing 19 pp.38-, 1998

Houldsworth SL; Trew AJ; Hooper NM; Turner AJ Molecular characterisation of the Alzheimer's amyloid precursor protein secretases Biochemical Society Transactions 26 -, 1998

Parkin ET; Hussain I; Turner AJ; Hooper NM The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains JOURNAL OF NEUROCHEMISTRY 69 2179-2188, 1997

Barnes K; Walkden BJ; Wilkinson TC; Turner AJ Expression of endothelin-converting enzyme in both neuroblastoma and glial cell lines and its localization in rat hippocampus Journal of Neurochemistry 68 570-577, 1997

Hooper NM; Karran EH; Turner AJ Membrane protein secretases BIOCHEMICAL JOURNAL 321 265-279, 1997

Turner AJ Neuropeptide inactivation in the central nervous system Cell-surface peptidases 275-301, 1997

Barnes K; Turner AJ The endothelin system and endothelin-converting enzyme in the brain: Molecular and cellular studies Neurochemical Research 22 1033-1040, 1997

Turner AJ; Tanzawa K Mammalian membrane metallo-peptidases: NEP, ECE, KELL and PEX The FASEB Journal 11 355-364, 1997

Lim PJ; Hyde RJ; Hooper NM; Turner AJ Site-directed mutaghnesis of conserved h1stidinf residues within the bradykinin degrading enzyme aminopfptidasf FASEB Journal 11 -, 1997

Turner AJ; Hyde RJ; Lim JS; Hooper NM Structural studies of aminopeptidase P - A novel cellular peptidase CELLULAR PEPTIDASES IN IMMUNE FUNCTIONS AND DISEASES 421 7-16, 1997

Keynan S; Asipu A; Hooper NM; Turner AJ; Blair GE Stable and temperature-sensitive transformation of baby rat kidney cells by SV40 suppresses expression of membrane dipeptidase ONCOGENE 15 1241-1245, 1997
DOI:10.1038/sj.onc.1201297

Parvathy S; Oppong SY; Karran EH; Buckle DR; Turner AJ; Hooper NM Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted in a lipid bilayer BIOCHEMICAL JOURNAL 327 37-43, 1997

Hanna MC; Turner AJ; Kirkness EF Human pyridoxal kinase: cDNA cloning, expression and modulation by ligands of the benzodiazepine receptor Journal of Biological Chemistry 272 10756-10760, 1997

Turner AJ; Hooper NM Three glycolipid-anchored peptidases: membrane dipeptidase, aminopeptidase P and carboxypeptidase M Cell-surface peptidases 219-238, 1997

Turner AJ Endothelin-converting enzyme Cell-surface peptidases 137-153, 1997

Turner AJ Membrane alanyl aminopeptidase Handbook of Proteolytic Enzymes 996-1000, 1997

Turner AJ Foreward: 20 Years of the European Society for Neurochemistry Neurochemistry: Cellular, molecular and clinical aspects v-vi, 1997

Turner AJ; Bachelard HS Neurochemistry: A practical approach, 1997

Turner AJ Neprilysin Handbook of Proteolytic Enzymes 1080-1085, 1997

Hooper NM; Turner AJ Inhibition of the formation of the Alzheimer'sβ-amyloid peptide, 1997

Turner AJ; Parkin ET; Hooper NM Glycosylation and glycophosphatidylinositol membrane anchors Regulatory Protein Modification: Techniques and Protocols 30 395-427, 1997

Hawthorne SJ; Harriott P; Lim J; Turner AJ; Walker B; Williams CH Evaluation of some fluorogenic substrates for continuous assay of aminopeptidase P Analytical Biochemistry 253 13-17, 1997

Hoang MV; Sansom CE; Turner AJ Mutagenesis of Glu403 to Cys in rabbit neutral endopeptidase-24.11, neprilysin) creates a disulfide-linked homodimer: analogy with endothelin-converting enzyme Biochemical Journal 327 925-929, 1997

Keynan S; Hooper NM; Turner AJ Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase, a novel mammalian zinc peptidase BIOCHEMICAL JOURNAL 326 47-51, 1997

Turner AJ New insights into the structure and function of the endopeptidase-24.11 family of ectoenzymes Neurochemistry: Cellular, molecular and clinical aspects 683-689, 1997

Hoang MV; Turner AJ Novel activity for endothelin converting enzyme hydrolysis of bradykinin Biochemical Journal 327 23-26, 1997

Turner AJ Structure and localisation of endothelin-converting enzyme British Journal of Pharmacology 122 pp.458-, 1997

Turner AJ; Tanzawa K Endothelin converting enzyme structure and localisation Zinc Metalloproteases in Health and Disease 311-330, 1996

Turner AJ New insights into the structure and function of the endopeptidase-24.11 family of ectoenzymes ISN Meeting, JOURNAL OF NEUROCHEMISTRY 66 pp.62-, 1996

Hyde RJ; Hooper NM; Turner AJ Cloning and functional expression of pig kidney aminopeptidase P Biochemical Society Transactions 24 -, 1996

Parkin ET; Turner AJ; Hooper NM A role for calcium and annexins in the formation of caveolae, 1996

Shimada K; Takahashi M; Turner AJ; Tanzawa K Rat endothelin-converting enzyme-1 forms a dimer through Cys412 with a similar catalytic mechanism and a distinct binding mechanism compared with neutral endopeptidase-24.11 Biochemical Journal 315 863-867, 1996

Lim J; Turner AJ Chemical modification of aminopeptidase P indicates the involvement of two critical histidine residues FEBS Letters 381 188-190, 1996

Turner AJ; Murphy LJ; Medeiros MS; Barnes K Endopeptidase-24.11 and relatives Intracellular protein catabolism 141-148, 1996

Barnes K; Shimada K; Tanzawa K; Takahashi M; Turner AJ Metallopeptidase inhibitors induce an up-regulation of endothelin-converting enzyme and its redistribution from the plasma membrane to an intracellular compartment Journal of Cell Science 109 919-928, 1996

Parkin ET; Turner AJ; Hooper NM Isolation and characterisation of detergent-insoluble membrane microdomains from porcine lung, 1996

Hyde RJ; Hooper NM; Turner AJ Molecular cloning and expression in COS-1 cells of pig kidney aminopeptidase P BIOCHEMICAL JOURNAL 319 197-201, 1996

Medeiros MS; Turner AJ Metabolism and functions of neuropeptide Y Neurochemical Research 21 1125-1132, 1996

Parkin ET; Turner AJ; Hooper NM Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes BIOCHEMICAL JOURNAL 319 887-896, 1996

Turner AJ; Murphy LJ Molecular pharmacology of endothelin-converting enzymes Biochemical Pharmacology 51 91-102, 1996

Keynan S; Hooper NM; Turner AJ Molecular and functional aspects of membrane dipeptidase Zinc Metalloproteases in Health and Disease 285-309, 1996

Hoang MV; Sansom CE; Turner AJ Mutagenesis and modelling of endothelin converting enzyme Biochemical Society Transactions 24 pp.471-, 1996

Keynan S; Habgood NT; Hooper NM; Turner AJ Site-directed mutagenesis of conserved cysteine residues in porcine membrane dipeptidase. Cys 361 alone is involved in disulfide-linked dimerization BIOCHEMISTRY 35 12511-12517, 1996
DOI:10.1021/bi961193z

Lloyd GS; Hryszko J; Hooper NM; Turner AJ Inhibition and metal ion activation of pig kidney aminopeptidase P - Dependence on nature of substrate BIOCHEMICAL PHARMACOLOGY 52 229-236, 1996
DOI:10.1016/0006-2952(96)00180-3

Turner AJ PIG-tailed membrane proteins ESSAYS IN BIOCHEMISTRY, VOL 28 28 113-127, 1994

Medeiros MS; Balmforth AJ; Vaughan PFT; Turner AJ Hydrolis of atrial and brain natriuretic peptides by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y. Neuroendocrinology Letters 54 295-302, 1991