Multidisciplinary Cardiovascular Research Centre

Ed White

Professor Ed White

BSc, Aberystwyth; PhD 1986, Reading; PGCE, Exeter.
Professor in Cardiac Physiology
Institute of Membrane and Systems Biology

Background: BSc Zoology, University of Wales, Aberystwyth: PhD Zoology, Reading University: PGCE Biology and Outdoor Education, Exeter University: Post-Doc., Oxford University: Lecturer, Universite de Tours, France: Lloyds of London and Wellcome Trust Fellow, Lecturer, Senior Lecturer, Reader: University of Leeds.

Office: Garstang 7.53a
Phone: +44(0) 113 34 34248
Email: e.white@leeds.ac.uk

Centre membership: The Multidisciplinary Cardiovascular Research Centre (MCRC)

Research Interests

Mechanical stimulation of the heart

Mechanical stimulation of the heart
Acute mechanical stimulation (e.g. stretch) affects the contractility of cardiac muscle in situations such as exercise, when diastolic ventricular volume is increased. Stretch and adrenergic stimulation are the 2 most important physiological mechanisms for increasing the strength of contraction of the heart. But stretch has also been implicated in the triggering of cardiac arrhythmias and chronic stretch provokes cardiac hypertrophy and eventually heart failure. Thus stretch may be involved in the beneficial effects of regular exercise and the cause of heart attacks, depending upon circumstances. My research group investigates the mechanisms that cause these varied effects on the contractile and electrical activity of the heart (see Fig 1).

Right heart failure
The right ventricle is structurally and functionally different from the left ventricle, it is thinner, operates at much lower pressures and has distinctive pathologies. The right ventricle is much less studied than the left. We are interested in the differences in physiology and pathology between the ventricles. We are currently using an animal model to study changes in contractile and electrical activity of the myocardium in right ventricular failure, linking these to changes in gene expression and in vivo cardiac function.

Comparative Cardiac Physiology
Vertebrate heart design varies from class to class, understanding the differences in physiology between vertebrate classes helps our thinking about mammalian physiology and pathology. In collaboration with colleagues from the University of Manchester we are investigating the cardiac physiology of fish.

Funding and international collaborations
We are currently funded by grants from The British Heart Foundation and The Medical Research Council. We have overseas research collaborators in France (Montpellier) and Australia (Adelaide). The laboratory has welcomed researchers from Australia, Brazil, Canada, France, Japan, Poland and the UAE.

Available Research Techniques
In vivo: ECG in unrestrained animals by telemetry; pressure:volume relationships of the ventricles.
Isolated whole hearts: Ventricular contractility (developed pressure) and electrical activity (monophasic action potentials)
Single cardiac myocytes: Myocyte contractility (cell shortening and force development); ionic membrane currents (patch clamping) and intracellular ion concentrations (fluorescence microscopy); cytoskeletal structure (immunohistochemistry and confocal microscopy).
Molecular Biology: measurement of mRNA (real time RT-PCR); protein expression (Western blotting)

Figure 1: A single cardiac myocyte about 0.1 mm in length being stretched by carbon fibres. A specialist technique in our lab. is the recording of force and stretch in single cardiac myocytes (click on Figure 1 for a video demonstration of this technique). Force measurements can be combined with measurements of intracellular calcium or electrophysiology.

Current Projects

Changes in ion channel activity in right heart failure
Role of stretch in right heart failure
Cardiac physiology of non-mammalian vertebrates

Studentship information

Undergraduate project topics:

Cardiac muscle

Postgraduate studentship areas:

Contractile and electrical activity in right ventricular failure
The role of mechanical stimulation in cardiac physiology and pathology
University of Leeds has an endowed PhD studentship (The Emma and Leslie Reid Studentship) in the field of heart research. Applications from self-funding 1-year MSc by research students are welcome.

Publications

Gilbert SH; Benoist D; Benson AP; White E; Tanner SF; Holden AV; Dobrzynski H; Bernus O; Radjenovic A Visualization and quantification of whole rat heart laminar structure using high-spatial resolution contrast-enhanced MRI AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 302 H287-H298, 2012
DOI:10.1152/ajpheart.00824.2011

Walton RD; Smith RM; Mitrea BG; White E; Bernus O; Pertsov AM Extracting Surface Activation Time from the Optically Recorded Action Potential in Three-Dimensional Myocardium BIOPHYSICAL JOURNAL 102 30-38, 2012
DOI:10.1016/j.bpj.2011.10.036

Benoist D; Stones R; Drinkhill MJ; Benson AP; Yang Z; Cassan C; Gilbert SH; Saint DA; Cazorla OF; Steele DS; Bernus O; White E Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. Am J Physiol Heart Circ Physiol -, 2012
DOI:10.1152/ajpheart.01084.2011

Patrick SM; White E; Shiels HA Rainbow trout myocardium does not exhibit a slow inotropic response to stretch Journal of Experimental Biology 214 1119-1122, 2011

White E; Benoist D; Bernus O Regional variation in mechano-electric coupling: the right ventricle In Cardiac Mechano-electric Coupling and Arrhythmias , 2011

White E Mechano-sensitive channel blockers: a new class of antiarrhythmic drugs? In Cardiac Mechano-electric Coupling and Arrhythmias , 2011

Patrick M; White E; Brill RW; Shiels HA The effect of stimulation frequency on the transmural ventricular monophasic action potential in yellowfin tuna Thunnus albacares JOURNAL OF FISH BIOLOGY 78 651-658, 2011
DOI:10.1111/j.1095-8649.2010.02869.x

Benoist D; Stones R; Drinkhill M; Bernus O; White E Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 300 H2230-H2237, 2011
DOI:10.1152/ajpheart.01226.2010

Patrick SM; White E; Shiels HA Rainbow trout myocardium does not exhibit a slow inotropic response to stretch JOURNAL OF EXPERIMENTAL BIOLOGY 214 1118-1122, 2011
DOI:10.1242/jeb.048546

White E Mechanical modulation of cardiac microtubules PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 462 177-184, 2011
DOI:10.1007/s00424-011-0963-0

Quinn TA; Granite S; Allessie MA; Antzelevitch C; Bollensdorff C; Bub G; Burton RAB; Cerbai E; Chen PS; Delmar M; DiFrancesco D; Earm YE; Efimov IR; Egger M; Entcheva E; Fink M; Fischmeister R; Franz MR; Garny A; Giles WR; Hannes T; Harding SE; Hunter PJ; Iribe G; Jalife J; Johnson CR; Kass RS; Kodama I; Koren G; Lord P; Markhasin VS; Matsuoka S; McCulloch AD; Mirams GR; Morley GE; Nattel S; Noble D; Olesen SP; Panfilov AV; Trayanova NA; Ravens U; Richard S; Rosenbaum DS; Rudy Y; Sachs F; Sachse FB; Saint DA; Schotten U; Solovyova O; Taggart P; Tung L; Varro A; Volders PG; Wang K; Weiss JN; Wettwer E; White E; Wilders R; Winslow RL; Kohl P Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): Standardised reporting for model reproducibility, interoperability, and data sharing PROGRESS IN BIOPHYSICS&MOLECULAR BIOLOGY 107 4-10, 2011
DOI:10.1016/j.pbiomolbio.2011.07.001

Wuest RCI; Benoist D; Stones R; Bowen TS; White E; Rossiter HB Adaptation of Skeletal Muscle O-2 Transport and Utilization in Rats with Right Heart Failure, 2010

Walton RD; Benoist D; Hyatt CJ; Gilbert SH; White E; Bernus O Dual excitation wavelength epifluorescence imaging of transmural electrophysiological properties in intact hearts HEART RHYTHM 7 1843-1849, 2010
DOI:10.1016/j.hrthm.2010.08.019

Patrick SM; Hoskins AC; Kentish JC; White E; Shiels HA; Cazorla O Enhanced length-dependent Ca2+ activation in fish cardiomyocytes permits a large operating range of sarcomere lengths JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 48 917-924, 2010
DOI:10.1016/j.yjmcc.2010.02.008

Patrick SM; White E; Shiels HA Mechano-Electric Feedback in the Fish Heart PLOS ONE 5 -, 2010
DOI:10.1371/journal.pone.0010548

Weiss S; Benoist D; White E; Teng W; Saint DA Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current BRITISH JOURNAL OF PHARMACOLOGY 160 1072-1082, 2010
DOI:10.1111/j.1476-5381.2010.00766.x

Tran T; Gillet L; Roger S; Besson P; White E; Le Guennec J Non-anti-mitotic concentrations of taxol reduce breast cancer cell invasiveness BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 379 304-308, 2009
DOI:10.1016/j.bbrc.2008.12.073

Pickering JD; White E; Duke AM; Steele DS DHPR activation underlies SR Ca2+ release induced by osmotic stress in isolated rat skeletal muscle fibers JOURNAL OF GENERAL PHYSIOLOGY 133 511-524, 2009
DOI:10.1085/jgp.200910191

Patrick SM; Shiels HJ; White E; Cazorla O Comparison of length-dependent Ca2+ activation of cardiac myofilaments between the rat and the rainbow trout, 2009
DOI:10.1016/j.cbpa.2009.04.114

Stones R; Billeter R; Zhang H; Harrison S; White E The role of transient outward K+ current in electrical remodelling induced by voluntary exercise in female rat hearts BASIC RESEARCH IN CARDIOLOGY 104 643-652, 2009
DOI:10.1007/s00395-009-0030-6

Kozera L; White E; Calaghan S Caveolae Act as Membrane Reserves Which Limit Mechanosensitive I-Cl,I-swell Channel Activation during Swelling in the Rat Ventricular Myocyte PLOS ONE 4 -, 2009
DOI:10.1371/journal.pone.0008312

Stones R; Gilbert SH; Benoist D; White E Inhomogeneity in the response to mechanical stimulation: Cardiac muscle function and gene expression PROGRESS IN BIOPHYSICS&MOLECULAR BIOLOGY 97 268-281, 2008
DOI:10.1016/j.pbiomolbio.2008.02.01

Stones R; Natali A; Billeter R; Harrison S; White E Voluntary exercise-induced changes in beta(2)-adrenoceptor signalling in rat ventricular myocytes EXPERIMENTAL PHYSIOLOGY 93 1065-1075, 2008
DOI:10.1113/expphysiol.2008.042598

Shiels HA; White E The Frank-Starling mechanism in vertebrate cardiac myocytes JOURNAL OF EXPERIMENTAL BIOLOGY 211 2005-2013, 2008
DOI:10.1242/jeb.003145

Calaghan S; Kozera L; White E Compartmentalisation of cAMP-dependent signalling by caveolae in the adult cardiac myocyte Journal of Molecular and Cellular Cardiology 45 88-92, 2008

Patrick S; Shiels H; White E The presence of mechanosensitive channels in the rainbow trout (Oncorhynchus mykiss) heart, 2008
DOI:10.1016/j.cbpa.2008.04.195

Calaghan S; Kozera L; White E Compartmentalisation of cAMP-dependent signalling by caveolae in the adult cardiac myocyte JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 45 88-92, 2008
DOI:10.1016/j.yjmcc.2008.04.004

Bingham AJ; Ooi L; Kozera L; White E; Wood IC The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes MOLECULAR AND CELLULAR BIOLOGY 27 4082-4092, 2007
DOI:10.1128/MCB.00269-07

Stones R; White E Regional variation in cardiac ventricular gene expression, 2007
DOI:10.1016/j.cbpa.2007.06.380

Calaghan S; Kozera L; White E Caveolae promote confinement of beta(2) adrenoceptor signalling to the sarcolemma in the adult cardiac myocyte, 2007

Patrick S; White E; Shiels H The effect of stretch on the electrical activity of the rainbow trout (Oncorhynchus mykiss) heart, 2007
DOI:10.1016/j.cbpa.2007.06.387

Shiels H; O'Connell A; Qureshi MA; Howarth FC; White E; Calaghan S Stable microtubules contribute to cardiac dysfunction in the streptozotocin-induced model of type 1 diabetes in the rat MOLECULAR AND CELLULAR BIOCHEMISTRY 294 173-180, 2007
DOI:10.1007/s11010-006-9257-9

Patrick S; White E; Brill RW; Shiels H The effect of heart rate on the monophasic action potential recorded in isolated yellowfin tuna (Thunnus albacares) cardiac muscle, 2007
DOI:10.1016/j.cbpa.2007.06.388

Stones R; Calaghan SC; Billeter R; Harrison SM; White E Transmural variations in gene expression of stretch-modulated proteins in the rat left ventricle PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 454 545-549, 2007
DOI:10.1007/s00424-007-0237-z

Calaghan S; White E Caveolae modulate excitation-contraction coupling and beta(2)-adrenergic signalling in adult rat ventricular myocytes CARDIOVASCULAR RESEARCH 69 816-824, 2006
DOI:10.1016/j.cardiores.2005.10.006

Calaghan S; White E Caveolae modulate excitation-contraction coupling and beta2-adrenergic signalling in adult rat ventricular myocytes. Cardiovasc Res 69 816-824, 2006
DOI:10.1016/j.cardiores.2005.10.006

White E Mechanosensitive channels: Therapeutic targets in the myocardium? CURRENT PHARMACEUTICAL DESIGN 12 3645-3663, 2006
DOI:10.2174/138161206778522083

Shiels HA; Calaghan SC; White E The cellular basis for enhanced volume-modulated cardiac output in fish hearts JOURNAL OF GENERAL PHYSIOLOGY 128 37-44, 2006
DOI:10.1085/jgp.200609543

Shiels H; White E The effects of stretch on auxotonic force and intracellular calcium transients in single cardiac ventricular myocytes from rainbow trout (Oncorhynchus mykiss), 2005

Stones RE; Billeter R; Harrison S; White E Effect of voluntary exercise training on the regional variation in current density of the transient outward current, Ito and expression of Kv4.2, in rat ventricular myocytes., 2005

Stones R; Billeter R; Harrison S; White E Heterogenic contractile response of rat left ventricular myocytes to beta(1)-adrenoceptor stimulation EUROPEAN JOURNAL OF PHARMACOLOGY 512 117-120, 2005
DOI:10.1016/j.ejphar.2005.02.020

Morton MJ; Thompson B; Stones R; Lancaster MK; White E; Harrison SM; Hunter M; Jones SA Exercise, and left ventricle transmural gradient of TASK-1 protein expression, 2005

Shiels HA; White E Temporal and spatial properties of cellular Ca2+ flux in trout ventricular myocytes AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 288 R1756-R1766, 2005
DOI:10.1152/ajpregu.00510.2004

White E Temporal modulation of mechano-electric feedback in cardiac muscle In Cardiac mechano-electric feedback and arrhythmias: from pipette to patient , 2005

Stones R; Billeter R; Harrison SM; White E Heterogenic contractile response of RAT left ventricular myocytes to (1)-adrenoceptor stimulation, 2005

Calaghan S; White E Disruption of caveolae modulates excitation-contraction coupling in the adult cardiac myocyte, 2005

Calaghan SC; White E Mechanical modulation of intracellular ion concentrations: Mechanisms and electrical consequences In Mechanosensitivity in Cells and Tissues , 2005

Calaghan S; White E Activation of Na+-H+ exchange and stretch-activated channels underlies the slow inotropic response to stretch in myocytes and muscle from the rat heart JOURNAL OF PHYSIOLOGY-LONDON 559 205-214, 2004
DOI:10.1113/jphysiol.2004.069021

McCrossan ZA; Billeter R; White E Transmural changes in size, contractile and electrical properties of SHR left ventricular myocytes during compensated hypertrophy CARDIOVASCULAR RESEARCH 63 283-292, 2004
DOI:10.1016/j.cardiores.2004.04.013

Calaghan SC; Le Guennec JY; White E Cytoskeletal modulation of electrical and mechanical activity in cardiac myocytes PROGRESS IN BIOPHYSICS&MOLECULAR BIOLOGY 84 29-59, 2004
DOI:10.1016/S0073-6107(03)00057-9

Belus A; White E Streptomycin and intracellular calcium modulate the response of single guinea-pig ventricular myocytes to axial stretch JOURNAL OF PHYSIOLOGY-LONDON 546 501-509, 2003
DOI:10.1113/jphysiol.2002.027573

Calaghan SC; Belus A; White E Do stretch-induced changes in intracellular calcium modify the electrical activity of cardiac muscle? PROGRESS IN BIOPHYSICS&MOLECULAR BIOLOGY 82 81-95, 2003
DOI:10.1016/S0079-6107(03)00007-5

Jude S; Bedut S; Roger S; Pinault M; Champeroux P; White E; Le Guennec JY Peroxidation of docosahexaenoic acid is responsible for its effects on I-TO and I-SS in rat ventricular myocytes BRITISH JOURNAL OF PHARMACOLOGY 139 816-822, 2003
DOI:10.1038/sj.bjp.0705308

Miller G; Maycock J; White E; Peckham M; Calaghan S Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes JOURNAL OF PHYSIOLOGY-LONDON 548 167-174, 2003
DOI:10.1113/jphysiol.2002.031922

Bird SD; Calaghan SC; White E Microtubule disruption with colchicine does not modify the cell volume or contractile response to hyposmotic challenge in the adult rat ventricular myocyte, 2002

Howarth FC; Qureshi MA; White E; Calaghan SC Cardiac microtubules are more resistant to chemical depolymerisation in streptozotocin-induced diabetes in the rat PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 444 432-437, 2002
DOI:10.1007/s00424-002-0824-y

Calaghan S; White E The slow inotropic response to stretch is independent of endothelin 1 in single rat ventricular myocytes, 2002

Howarth FC; Qureshi MA; White E Effects of hyperosmotic shrinking on ventricular myocyte shortening and intracellular Ca2+ in streptozotocin-induced diabetic rats PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 444 446-451, 2002
DOI:10.1007/s00424-002-0830-0

Natali AJ; Wilson LA; Peckham M; Turner DL; Harrison SM; White E Different regional effects of voluntary exercise on the mechanical and electrical properties of rat ventricular myocytes JOURNAL OF PHYSIOLOGY-LONDON 541 863-875, 2002
DOI:10.1113/jphysiol.2001.013415

Belus A; White E Effects of streptomycin sulphate on I-CaL, I-Kr and I-Ks in guinea-pig ventricular myocytes EUROPEAN JOURNAL OF PHARMACOLOGY 445 171-178, 2002
DOI:10.1016/S0014-2999(02)01791-0

Ansari SS; Shiels HA; Calaghan SC; White E Laminin potentiates the contractile response to beta-adrenergic, but not endothelin-1, stimulation in rat ventricular myocytes, 2002

Calaghan S; White E Signalling pathways that underlie the slow inotropic response to myocardial stretch, 2002

Calaghan S; Miller G; White E; Peckham M Effect of familial hypertrophic cardiomyopathy (FHC) mutations in beta-cardiac myosin on the contractile kinetics of cultured myotubes, 2002

Calaghan SC; Le Guennec JY; White E Microtubule disruption by colchicine modulates I-Ca,I-L in ruptured but not perforated patch-clamped cardiomyocytes., 2001

Calaghan S; White E; Le Guennec JY A unifying mechanism for the role of microtubules in the regulation of [Ca2+](i) and contraction in the cardiac myocyte CIRCULATION RESEARCH 89 E31-E31, 2001

McCrossan ZA; White E Effects of endothelin-1 on the contraction and [Ca2+]I of myocytes isolated from different regions of WKY and SHR left ventricle, 2001

Natali AJ; Turner DL; Harrison SM; White E Regional effects of voluntary exercise on cell size and contraction-frequency responses in rat cardiac myocytes JOURNAL OF EXPERIMENTAL BIOLOGY 204 1191-1199, 2001

Belus A; White E Effects of antibiotics on the contractility and Ca2+ transients of rat cardiac myocytes EUROPEAN JOURNAL OF PHARMACOLOGY 412 121-126, 2001
DOI:10.1016/S0014-2999(01)00717-8

Calaghan SC; White E Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 441 514-520, 2001
DOI:10.1007/s004240000458

Belus A; White E Effects of streptomycin on the L-type Ca2+ and delayed rectifier currents of single guinea pig ventricular myocytes, 2001

Calaghan SC; White E; Qureshi MA; Howarth FC Does the microtubular cytoskeleton contribute to cardiac dysfunction in streptozotocin-induced diabetes in the rat?, 2001

Calaghan SC; Le Guennec JY; White E Modulation of Ca2+ signaling by microtubule disruption in rat ventricular myocytes and its dependence on the ruptured patch-clamp configuration CIRCULATION RESEARCH 88 E32-E37, 2001

Belus A; White E Effect of streptomycin and BAPTA on stretch-induced changes in action potentials of isolated guinea-pig ventricular myocytes, 2001

Calaghan SC; White E; Le Guennec JY A unifying mechanism for the role of microtubules in the regulation of [Ca2+]i and contraction in cardiac myocytes Circulation Research 89 pp.31-, 2001

McCrossan ZA; White E Transmural action potential characteristics in left ventricular myocytes from Wistar-Kyoto and spontaneously hypertensive rats, 2001

Calaghan SC; White E; Bedut S; Le Guennec JY Cytochalasin D reduces Ca2+ sensitivity and maximum tension via interactions with myofilaments in skinned rat cardiac myocytes JOURNAL OF PHYSIOLOGY-LONDON 529 405-411, 2000
DOI:10.1111/j.1469-7793.2000.00405.x

Calaghan SC; Trinick J; Knight PJ; White E A role for C-protein in the regulation of contraction and intracellular Ca2+ in intact rat ventricular myocytes Journal of Physiology 528 151-156, 2000

Hongo K; Brette F; Haroon MM; White E Mechanisms associated with the negative inotropic effect of deuterium oxide in single rat ventricular myocytes EXPERIMENTAL PHYSIOLOGY 85 133-142, 2000
DOI:10.1017/S0958067000019357

Brette F; Calaghan SC; Lappin S; White E; Colyer J; Le Guennec JY Biphasic effects of hyposmotic challenge on excitation-contraction coupling in rat ventricular myocytes AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 279 H1963-H1971, 2000

Cazorla O; Le Guennec JY; White E Regional differences in the length-tension relationship of single centricular myocytes from rate and ferret hearts Journal of Molecular and Cellular Cardiology 32 735-744, 2000

Harwood CL; Howarth FC; Altringham JD; White E Rate-dependent changes in cell shortening, intracellular Ca2+ levels and membrane potential in single, isolated rainbow trout (Oncorhynchus mykiss) ventricular myocytes JOURNAL OF EXPERIMENTAL BIOLOGY 203 493-504, 2000

Kohl P; Le Guennec JY; White E The relationship of diastolic function and electrophysiology Cardiology Clinics 18 1010-1015, 2000

Calaghan SC; Trinick J; Knight PJ; White E A role for C-protein in the regulation of contraction and intracellular Ca2+ in intact rat ventricular myocytes JOURNAL OF PHYSIOLOGY-LONDON 528 151-156, 2000
DOI:10.1111/j.1469-7793.2000.00151.x

Calaghan SC; Colyer J; White E Cyclic AMP but not phosphorylation of phospholamban contributes to the slow inotropic response to stretch in ferret papillary muscle PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 437 780-782, 1999
DOI:10.1007/s004240050846

Calaghan SC; White E The role of calcium in the response of cardiac muscle to stretch PROGRESS IN BIOPHYSICS&MOLECULAR BIOLOGY 71 59-90, 1999
DOI:10.1016/S0079-6107(98)00037-6

Howarth FC; Calaghan SC; Boyett MR; White E Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transient and L-type Ca2+ current in rat ventricular myocytes JOURNAL OF PHYSIOLOGY-LONDON 516 409-419, 1999
DOI:10.1111/j.1469-7793.1999.0409v.x

Howarth FC; Boyett MR; White E Rapid effects of cytochalasin-D on contraction and intracellular calcium in single rat ventricular myocytes PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 436 804-806, 1998
DOI:10.1007/s004240050706

Calaghan SC; White E; Colyer J Co-ordinated changes in cAMP, phosphorylated phospholamban, Ca2+ and contraction following beta-adrenergic stimulation of rat heart PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 436 948-956, 1998
DOI:10.1007/s004240050728

Pascarel C; Hongo K; Cazorla O; White E; Le Guennec JY Different effects of gadolinium on I-KR, I-KS and I-K1 in guinea-pig isolated ventricular myocytes BRITISH JOURNAL OF PHARMACOLOGY 124 356-360, 1998
DOI:10.1038/sj.bjp.0701835

Calaghan S; White E; Colyer J Preservation of the in vivo phosphorylation status of phospholamban in the heart: Evidence for a site-specific difference in the dephosphorylation of phospholamban BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 248 701-705, 1998
DOI:10.1006/bbrc.1998.9036

Pascarel C; Cazorla O; Le Guennec JY; Orchard CH; White E The effect of the venom of a Chilean tarantula, Phrixotrichus spatulatus, on isolated guinea pig ventricular myocytes TOXICOLOGY AND APPLIED PHARMACOLOGY 147 363-371, 1997
DOI:10.1006/taap.1997.8291

Hongo K; Pascarel C; Cazorla O; Gannier F; LeGuennec JY; White E Gadolinium blocks the delayed rectifier potassium current in isolated guinea-pig ventricular myocytes EXPERIMENTAL PHYSIOLOGY 82 647-656, 1997

Hongo K; White E; LeGuennec JY; Orchard CH Changes in [Ca2+](i), [Na+](i) and Ca2+ current in isolated rat ventricular myocytes following an increase in cell length JOURNAL OF PHYSIOLOGY-LONDON 491 609-619, 1996

Gannier F; White E; Garnier D; LeGuennec JY A possible mechanism for large stretch-induced increase in [Ca2+](i) in isolated guinea-pig ventricular myocytes CARDIOVASCULAR RESEARCH 32 158-167, 1996
DOI:10.1016/S0008-6363(95)00153-0

White E Length-dependent mechanisms in single cardiac cells EXPERIMENTAL PHYSIOLOGY 81 885-897, 1996

HONGO K; WHITE E; ORCHARD C THE EFFECT OF MECHANICAL LOADING ON THE RESPONSE OF RAT VENTRICULAR MYOCYTES TO ACIDOSIS EXPERIMENTAL PHYSIOLOGY 80 701-712, 1995

HONGO K; WHITE E; ORCHARD C EFFECT OF STRETCH ON CONTRACTION AND THE CA2+ TRANSIENT IN FERRET VENTRICULAR MUSCLES DURING HYPOXIA AND ACIDOSIS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 269 C690-C697, 1995

ORCHARD C; MUSTAFA M; WHITE E OSCILLATIONS AND WAVES OF INTRACELLULAR [CA2+] IN CARDIAC-MUSCLE-CELLS CHAOS SOLITONS&FRACTALS 5 447-458, 1995
DOI:10.1016/0960-0779(93)E0036-B

Hongo K; White E; Orchard CH Effect of stretch on contraction and the Ca2+ transient in ferret ventricular muscles during hypoxia and acidosis. Am J Physiol 269 C690-C697, 1995

MUSTAFA M; WHITE E; HONGO K; OTHMAN I; ORCHARD C THE MECHANISM UNDERLYING THE CARDIOTOXIC EFFECT OF THE TOXIN FROM THE JELLYFISH CHIRONEX FLECKERI TOXICOLOGY AND APPLIED PHARMACOLOGY 133 196-206, 1995
DOI:10.1006/taap.1995.1142

WHITE E; BOYETT M; ORCHARD C THE EFFECTS OF MECHANICAL LOADING AND CHANGES OF LENGTH ON SINGLE GUINEA-PIG VENTRICULAR MYOCYTES JOURNAL OF PHYSIOLOGY-LONDON 482 93-107, 1995

SHAH N; THAN N; WHITE E; BENNETT K; ORCHARD C THE ROLE OF THE SARCOPLASMIC-RETICULUM IN THE RESPONSE OF ISOLATED FERRET CARDIAC-MUSCLE TO BETA-ADRENERGIC STIMULATION EXPERIMENTAL PHYSIOLOGY 79 929-941, 1994

GANNIER F; WHITE E; LACAMPAGNE A; GARNIER D; LEGUENNEC J STREPTOMYCIN REVERSES A LARGE STRETCH-INDUCED INCREASE IN [CA2+](I) IN ISOLATED GUINEA-PIG VENTRICULAR MYOCYTES CARDIOVASCULAR RESEARCH 28 1193-1198, 1994
DOI:10.1093/cvr/28.8.1193

WARD H; WHITE E REDUCTION IN THE CONTRACTION AND INTRACELLULAR CALCIUM TRANSIENT OF SINGLE-RAT VENTRICULAR MYOCYTES BY GADOLINIUM AND THE ATTENUATION OF THESE EFFECTS BY EXTRACELLULAR NAH2PO4 EXPERIMENTAL PHYSIOLOGY 79 107-110, 1994

WHITE E; CONNORS S; GILL E; TERRAR D THE POSITIVE INOTROPIC EFFECT OF COMPOUND-II, A NOVEL ANALOG OF SOTALOL, ON GUINEA-PIG PAPILLARY-MUSCLES AND SINGLE VENTRICULAR MYOCYTES BRITISH JOURNAL OF PHARMACOLOGY 110 95-98, 1993

CANNINGS I; HARRISON S; WHITE E; BOYETT M THE EFFECT OF A RANGE OF ALCOHOLS ON THE CONTRACTION OF GUINEA-PIG VENTRICULAR MYOCYTES EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION 248 213-216, 1993
DOI:10.1016/0926-6917(93)90046-S

WHITE E; LEGUENNEC J; NIGRETTO J; GANNIER F; ARGIBAY J; GARNIER D THE EFFECTS OF INCREASING CELL LENGTH ON AUXOTONIC CONTRACTIONS - MEMBRANE-POTENTIAL AND INTRACELLULAR CALCIUM TRANSIENTS IN SINGLE GUINEA-PIG VENTRICULAR MYOCYTES EXPERIMENTAL PHYSIOLOGY 78 65-78, 1993

WHITE E; TERRAR D INACTIVATION OF CA CURRENT DURING THE ACTION-POTENTIAL IN GUINEA-PIG VENTRICULAR MYOCYTES EXPERIMENTAL PHYSIOLOGY 77 153-164, 1992

WHITE E; TERRAR D ACTION-POTENTIAL DURATION AND THE INOTROPIC RESPONSE TO REDUCED EXTRACELLULAR POTASSIUM IN GUINEA-PIG VENTRICULAR MYOCYTES EXPERIMENTAL PHYSIOLOGY 76 705-716, 1991

BONNET P; ARGIBAY J; WHITE E; GARNIER D DIFFERENCES IN THE HYPOXIC CONTRACTION OF SMALL ISOLATED PULMONARY-ARTERIES OF CAT AND RABBIT JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY 161 543-547, 1991

LEGUENNEC J; WHITE E; GANNIER F; ARGIBAY J; GARNIER D STRETCH-INDUCED INCREASE OF RESTING INTRACELLULAR CALCIUM-CONCENTRATION IN SINGLE GUINEA-PIG VENTRICULAR MYOCYTES EXPERIMENTAL PHYSIOLOGY 76 975-978, 1991

WHITE E; TERRAR D THE ACTION OF STROPHANTHIDIN ON CALCIUM-ACTIVATED CURRENT AND CONTRACTION IN SINGLE GUINEA-PIG VENTRICULAR MYOCYTES EXPERIMENTAL PHYSIOLOGY 75 559-572, 1990

WHITE E; TERRAR D THE EFFECTS OF RYANODINE AND CAFFEINE ON CA-ACTIVATED CURRENT IN GUINEA-PIG VENTRICULAR MYOCYTES BRITISH JOURNAL OF PHARMACOLOGY 101 399-405, 1990

TERRAR D; WHITE E MECHANISMS AND SIGNIFICANCE OF CALCIUM ENTRY AT POSITIVE MEMBRANE-POTENTIALS IN GUINEA-PIG VENTRICULAR MUSCLE-CELLS QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES 74 121-139, 1989

TERRAR D; WHITE E CHANGES IN CYTOSOLIC CALCIUM MONITORED BY INWARD CURRENTS DURING ACTION-POTENTIALS IN GUINEA-PIG VENTRICULAR CELLS PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 238 171-188, 1989
DOI:10.1098/rspb.1989.0074

TERRAR D; WHITE E MECHANISM OF POTENTIATION OF CONTRACTION BY DEPOLARIZATION DURING ACTION-POTENTIALS IN GUINEA-PIG VENTRICULAR MUSCLE QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES 74 355-358, 1989

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