Dr Stacy-Paul Wilshaw

BSc, PhD Oct 2006, Leeds
Senior Translational Research Fellow in Cardiovascular Tissue Engineering
Institute of Molecular and Cellular Biology

Office: Garstang 6.57
Phone: +44(0) 113 34 35619
Email: s.wilshaw@leeds.ac.uk 

Centre membership:

• The Institute of Medical and Biological Engineering
• The Multidisciplinary Cardiovascular Research Centre (MCRC)

You can read more about Dr Wilshaw's interests here:
www.imbe.org.uk/

Research Interests

Tissue Replacement and Regeneration, Cardiovascular Tissue Engineering

 •   Tissue Engineering and Wound Healing

•   Biomaterials and Biomaterial/Tissue interactions

•   Vascular Biology and the Cardiovascular system

My research is mainly focused on the production and characterisation of acellular immunocompatible soft tissue matrices.  Our group has developed patented methods for the decellularisation of allogeneic and xenogeneic tissues including, aortic roots, pericardium, amniotic membrane and arteries.  These matrices have been extensively characterised and are being evaluated for their ability to regenerate into functional living tissues.  These tissue matrices are currently being seeded with cells to determine the biocompatibility and potential for regeneration.

Further research is focused on the creation of novel in vitro models of healthy and diseased arteries, which may be used to evaluate novel grafts or therapeutics.

Studentship information

Undergraduate project topics:

• Cardiovascular Tissue engineering, wound healing, immunological reactions to biomaterials.

Postgraduate studentship areas:

• Tissue Engineering and Regenerative Medicine

See also:

• Faculty Graduate School

Publications

Wilshaw S; Rooney P; Berry H; Kearney JN; Homer-Vanniasinkam S; Fisher J; Ingham E Development and Characterization of Acellular Allogeneic Arterial Matrices TISSUE ENGINEERING PART A 18 471-483, 2012
DOI:10.1089/ten.tea.2011.0287

Tatterton M; Wilshaw SP; Ingham E; Homer-Vanniasinkam S The use of antithrombotic therapies in reducing synthetic small-diameter vascular graft thrombosis. Vasc Endovascular Surg 46 212-222, 2012
DOI:10.1177/1538574411433299

Owen K; Wilshaw S; Homer-Vanniasinkam S; Bojar RA; Berry H; Ingham E Assessment of the Antimicrobial Activity of Acellular Vascular Grafts European Journal of Vascular and Endovascular Surgery -, 2012

Wang L; Wilshaw S; Korossis S; Fisher J; Jin Z; Ingham E Factors Influencing the Oxygen Consumption Rate of Aortic Valve Interstitial Cells: Application to Tissue Engineering TISSUE ENGINEERING PART C-METHODS 15 355-363, 2009
DOI:10.1089/ten.tec.2008.0415

Rimmer S; Wilshaw S; Pickavance P; Ingham E Cytocompatibility of poly(1,2 propandiol methacrylate) copolymer hydrogels and conetworks with or without alkyl amine functionality BIOMATERIALS 30 2468-2478, 2009
DOI:10.1016/j.biomaterials.2009.01.041

Wilshaw S; Burke D; Fisher J; Ingham E Investigation of the Antiadhesive Properties of Human Mesothelial Cells Cultured In Vitro on Implantable Surgical Materials JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 88B 49-60, 2009
DOI:10.1002/jbm.b.31148

Wang L; Wilshaw SP; Korossis S; Fisher J; Jin Z; Ingham E Factors Influencing the Oxygen Consumption Rate of Aortic Valve Interstitial Cells: Application to Tissue Engineering., 2009
DOI:10.1089/ten.tea.2008.0415

Shortt AJ; Secker GA; Lomas RJ; Wilshaw SP; Kearney JN; Tuft SJ; Daniels JT The effect of amniotic membrane preparation method on its ability to serve as a substrate for the ex-vivo expansion of limbal epithelial cells BIOMATERIALS 30 1056-1065, 2009
DOI:10.1016/j.biomaterials.2008.10.048

Wang L; Wilshaw S; Korossis S; Fisher J; Jin ZM; Ingham E Measurement of oxygen consumption rate for aortic valve interstitial cells (VICs): Application to tissue engineering, 2008

Wilshaw SP; Aggeli A; Fisher J; Ingham E The biocompatibility and immunogenicity of self-assembling peptides for use in tissue engineering and regenerative applications, 2008

Wilshaw S; Kearney J; Fisher J; Ingham E Biocompatibility and potential of acellular human amniotic membrane to support the attachment and proliferation of allogeneic cells TISSUE ENGINEERING PART A 14 463-472, 2008
DOI:10.1089/tea.2007.0145

Bolland F; Korossis S; Wilshaw S; Ingham E; Fisher J; Kearney JN; Southgate J Development and characterisation of a full-thickness acellular porcine bladder matrix for tissue engineering BIOMATERIALS 28 1061-1070, 2007
DOI:10.1016/j.biomaterials.2006.10.005

Wilshaw S; Kearney JN; Fisher J; Ingham E Production of an acellular amniotic membrane matrix for use in tissue engineering TISSUE ENGINEERING 12 2117-2129, 2006
DOI:10.1089/ten.2006.12.2117