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Burton PR; Clayton DG; Cardon LR; Craddock N; Deloukas P; Duncanson A; Kwiatkowski DP; McCarthy MI; Ouwehand WH; Samani NJ; Todd JA; Donnelly P; Barrett JC; Davison D; Easton D; Evans D; Leung H; Marchini JL; Morris AP; Spencer CCA; Tobin MD; Attwood AP; Boorman JP; Cant B; Everson U; Hussey JM; Jolley JD; Knight AS; Koch K; Meech E; Nutland S; Prowse CV; Stevens HE; Taylor NC; Walters GR; Walker NM; Watkins NA; Winzer T; Jones RW; McArdle WL; Ring SM; Strachan DP; Pembrey M; Breen G; St Clair D; Caesar S; Gordon-Smith K; Jones L; Fraser C; Green EK; Grozeva D; Hamshere ML; Holmans PA; Jones IR; Kirov G; Moskvina V; Nikolov I; O'Donovan MC; Owen MJ; Collier DA; Elkin A; Farmer A; Williamson R; McGuffin P; Young AH; Ferrier IN; Ball SG; Balmforth AJ; Barrett JH; Bishop DT; Iles MM; Maqbool A; Yudasheve N; Hall AS; Braund PS; Dixon RJ; Mangino M; Stevens S; Thompson JR; Bredin F; Tremelling M; Parkes M; Drummond H; Lees CW; Nimmo ER; Satsangi J; Fisher SA; Forbes A; Lewis CM; Onnie CM; Prescott NJ; Sanderson J; Mathew CG; Barbour J; Mohiuddin MK; Todhunter CE; Mansfield JC; Ahmad T; Cummings FR; Jewell DP; Webster J; Brown MJ; Lathrop GM; Connell J; Dominiczak A; Marcano CAB; Burke B; Dobson R; Gungadoo J; Lee KL; Munroe PB; Newhouse SJ; Onipinla A; Wallace C; Xue M; Caulfield M; Farrall M; Barton A; Bruce IN; Donovan H; Eyre S; Gilbert PD; Hider SL; Hinks AM; John SL; Potter C; Silman AJ; Symmons DPM; Thomson W; Worthington J; Dunger DB; Widmer B; Frayling TM; Freathy RM; Lango H; Perry JRB; Shields BM; Weedon MN; Hattersley AT; Hitman GA; Walker M; Elliott KS; Groves CJ; Lindgren CM; Rayner NW; Timpson NJ; Zeggini E; Newport M; Sirugo G; Lynons E; Vannberg F; Brown MA; Franklyn JA; Heward JM; Simmonds MJ; Hill AVS; Bradbury LA; Farrar C; Pointon JJ; Wordsmith P; Gough SCL; Seal S; Stratton MR; Rahman N; Ban M; Goris A; Sawcer SJ; Compston A; Conway D; Jallow M; Bumpstead SJ; Chaney A; Downes K; Ghori MJR; Gwilliam R; Inouye M; Keniry A; King E; McGinnis R; Potter S; Ravindrarajah R; Whittaker P; Withers D; Easton D; Pereira-Gale J; Hallgrimsdottir IB; Howie BN; Su Z; Teo YY; Vukcevic D; Bentley D; Caulfield M; Mathew CG; Worthington J; Consortium WTCC; Syndicate BRAGGS; Collaborat BCS (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. NATURE, 447 , pp. 661-678.

Talmud PJ; Flavell DM; Alfakih K; Cooper JA; Balmforth AJ; Sivananthan M; Montgomery HE; Hall AS; Humphries SE (2007) The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease. CLINICAL SCIENCE, 112 , pp. 617-624.

Nsengimana J; Samani NJ; Hall AS; Balmforth AJ; Mangino M; Yuldasheva N; Maqbool A; Braund P; Burton P; Bishop DT; Ball SG; Barrett JH; Study BHFFH (2007) Enhanced linkage of a locus on chromosome 2 to premature coronary artery disease in the absence of hypercholesterolemia. EUROPEAN JOURNAL OF HUMAN GENETICS, 15 , pp. 313-319.

Nejentsev S; Howson JMM; Walker NM; Szeszko J; Field SF; Stevens HE; Reynolds P; Hardy M; King E; Masters J; Hulme J; Maier LM; Smyth D; Bailey R; Cooper JD; Ribas G; Campbell RD; Clayton DG; Todd JA; Burton PR; Cardon LR; Craddock N; Deloukas P; Duncanson A; Kwiatkowski DP; McCarthy MI; Ouwehand WH; Samani NJ; Donnelly P; Barrett JC; Davison D; Easton D; Evans D; Leung H; Marchini JL; Morris AP; Spencer CCA; Tobin MD; Attwood AP; Boorman JP; Cant B; Everson U; Hussey JM; Jolley JD; Knight AS; Koch K; Meech E; Nutland S; Prowse CV; Taylor NC; Walters GR; Watkins NA; Winzer T; Jones RW; McArdle WL; Ring SM; Strachan DP; Pembrey M; Breen G; St Clair D; Caesar S; Gordon-Smith K; Jones L; Fraser C; Green EK; Grozeva D; Hamshere ML; Holmans PA; Jones IR; Kirov G; Moskvina V; Nikolov I; O'Donovan MC; Owen MJ; Collier DA; Elkin A; Farmer A; Williamson R; McGuffin P; Young AH; Ferrier IN; Ball SG; Balmforth AJ; Barrett JH; Bishop DT; Iles MM; Maqbool A; Yuldasheva N; Hall AS; Braund PS; Dixon RJ; Mangino M; Stevens S; Thompson JR; Bredin F; Tremelling M; Parkes M; Drummond H; Lees CW; Nimmo ER; Satsangi J; Fisher SA; Forbes A; Lewis CM; Onnie CM; Prescott NJ; Sanderson J; Mathew CG; Barbour J; Mohiuddin MK; Todhunter CE; Mansfield JC; Tariq A; Cummings FR; Jewell DP; Webster J; Brown MJ; Lathrop GM; Connell J; Dominiczak A; Braga Marcano CA; Burke B; Dobson R; Gungadoo J; Lee KL; Munroe PB; Newhouse SJ; Onipinla A; Wallace C; Xue M; Caulfield M; Farrall M; Barton A; Bruce IN; Donovan H; Eyre S; Gilbert PD; Hider SL; Hinks AM; John SL; Potter C; Silman AJ; Symmons DPM; Thomson W; Worthington J; Dunger DB; Widmer B; Frayling TM; Freathy RM; Lango H; Perry JRB; Shields BM; Weedon MN; Hattersley AT; Hitman GA; Walker M; Elliott KS; Groves CJ; Lindgren CM; Rayner NW; Timpson NJ; Zeggini E; Newport M; Sirugo G; Lyons E; Vannberg F; Hill AVS; Bradbury LA; Farrar C; Pointon JJ; Wordsworth P; Brown MA; Franklyn JA; Heward JM; Simmonds MJ; Gough SCL; Seal S; Stratton MR; Rahman N; Ban M; Goris A; Sawcer SJ; Compston A; Conway D; Jallow M; Rockett KA; Bryan C; Bumpstead SJ; Chaney A; Downes K; Ghori J; Gwilliam R; Hunt SE; Inouye M; Keniry A; King E; McGinnis R; Potter S; Ravindrarajah R; Whittaker P; Withers D; Cardin NJ; Ferreira T; Pereira-Gale J; Hallgrimsdóttir IB; Howie BN; Su Z; Yik YT; Vukcevic D; Bentley D; Compston A (2007) Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature, 450 (7171), pp. 887-892.

Alfakih K; Brown B; Lawrance RA; Warburton P; Maqbool A; Walters K; Samani NJ; Ball SG; Balmforth AJ; Hall AS (2007) Effect of a common X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) on the occurrence of premature myocardial infarction and stenotic atherosclerosis requiring revascularization. Atherosclerosis, 195 (1), pp. e32-e38.

Savva J; Maqbool A; Turner NA; Warburton P; Ball SG; Balmforth AJ (2006) Identification of haplotypes of the human A(2c)-adrenergic receptor and their associated function. HEART, 92 .

Ellis J; Warburton P; Donnelly D; Balmforth AJ (2006) Conformational induction is the key process for activation of the AT(1) receptor. BIOCHEMICAL PHARMACOLOGY, 71 , pp. 464-471.

Samani NJ; Burton P; Mangino M; Ball SG; Balmforth AJ; Barrett J; Bishop T; Hall A; Samani NJ; Stribling J; de Souza P; Singh R; Ogleby J; Ridge C; Logtens E; Hopwood L; Faulkes J; Hall AS; Morrell C; Jackson BM; Barthorpe L; Burtonwood N; Dorsch M; Durham N; Forest C; Kelly N; Hall V; Lawrance R; Oldham J; Rennie E; Smith A; Thompson S; Balmforth AJ; Mangino M; Adams S; Braund P; Clemitson JR; Bodycote C; Koekemoer A; Raleigh S; Maqbool A; Yuldasheva N; Ellis S; Mason S; Midgley L; Pleasants N; Cuthbert R; Tooze PF; Braund P; Mangino M; Platts M; Fox J; Dixon R; Barrett J; Burton P; Mangino M; Sheehan N; Scurrah K; Bishop T; Pickett S; Walters K; Nsengimana J; Hall AS; Samani NJ; Balmforth AJ; Burton P; Bishop T; Ball SG; Grp BHFFHSR (2005) A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British heart foundation (BHF) family heart study. AMERICAN JOURNAL OF HUMAN GENETICS, 77 , pp. 1011-1020.

Smith WHT; Nair RU; Adamson D; Kearney MT; Ball SG; Balmforth AJ (2005) Somatostatin receptor subtype expression in the human heart: differential expression by myocytes and fibroblasts. JOURNAL OF ENDOCRINOLOGY, 187 , pp. 379-386.

Samani NJ; Hall AS; Balmforth AJ; Mangino M; Barrett JA; Bishop T; Burton PB; Ball SG (2005) A genome-wide linkage study of 1933 families affected by premature coronary artery disease: The British Heart Foundation Family Heart Study. Circulation (Baltimore), 112 (17), pp. pp.413.

Scragg JL; Warburton P; Ball SG; Balmforth AJ (2005) Constitutive activity of human angiotensin II type-1 receptors by G(q) overexpression. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 334 , pp. 134-139.

Scragg JL; Ball SG; Balmforth AJ (2005) Constitutive activity of endogenous receptors by inducible G(q) overexpression. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 331 , pp. 1239-1244.

Brown BD; Lawrance RA; Steiner L; Balmforth AJ; Hall AS (2005) Inflammatory genotypes predisposing to premature coronary. Heart, 91 , pp. pp.67.

Alfakih K; Lawrance RA; Maqbool A; Walters K; Ball SG; Balmforth AJ; Hall AS (2005) The clinical significance of a common, functional, X-linked angiotensin II type 2-receptor gene polymorphism (-1332 G/A) in a cohort of 509 families with premature coronary artery disease. EUROPEAN HEART JOURNAL, 26 , pp. 584-589.

Sedo AJ; Drinkhill MJ; Ball SG; Balmforth AJ; Ainscough JFX (2005) Conditional expression of human Angiotensin II type I receptors in adult mouse cardiac myocytes. Transgenic Research, 14 (4), pp. pp.520.

Alfakih K; Maqbool A; Sivananthan M; Walters K; Bainbridge G; Ridgway J; Balmforth AJ; Hall AS (2004) Left ventricle mass index and the common, functional, X-linked angiotensin II type-2 receptor gene polymorphism (-1332 G/A) in patients with systemic hypertension. HYPERTENSION, 43 , pp. 1189-1194.

Brown BD; Balmforth AJ; Hall AS (2004) A multilocus evaluation of inflammatory and immunomodulatory genes in patients with premature coronary artery disease using the Sibship Disequilibrium Test. HEART, 90 , pp. A53-A54.

Porter KE; Turner NA; O'Regan DJ; Balmforth AJ; Ball SG (2004) Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA. CARDIOVASCULAR RESEARCH, 61 , pp. 745-755.

Dorsch MF; Barrett JA; Lawrance RA; Maqbool A; Durham NP; Ellis S; Samani NJ; Bishop T; Ball SG; Balmforth AJ; Hall AS (2003) Premature coronary artery disease shows no evidence of linkage to loci encoding for tissue inhibitors of matrix metalloproteinases. JOURNAL OF HUMAN GENETICS, 48 , pp. 508-513.

White HL; de Boer RA; Maqbool A; Greenwood D; van Veldhuisen DJ; Cuthbert R; Ball SG; Hall AS; Balmforth AJ; Grp MS (2003) An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study. EUROPEAN JOURNAL OF HEART FAILURE, 5 , pp. 463-468.

Turner NA; Porter KE; Smith WHT; White HL; Ball SG; Balmforth AJ (2003) Chronic beta(2)-adrenergic receptor stimulation increases proliferation of human cardiac fibroblasts via an autocrine mechanism. CARDIOVASCULAR RESEARCH, 57 , pp. 784-792.

White HL; Maqbool A; McMahon AD; Yates L; Ball SG; Hall AS; Balmforth AJ (2002) An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events - A WOSCOPS substudy. EUROPEAN HEART JOURNAL, 23 , pp. 1087-1092.

White HL; Maqbool A; McMahon A; Yates L; Ball SG; Hall AS; Balmforth AJ (2001) The Gly389 variant of the beta 1-adrenergic receptor does not confer protection against coronary events. CIRCULATION, 104 , pp. 285-285.

Turner NA; Ball SG; Balmforth AJ (2001) The mechanism of angiotensin Ii-induced extracellular signal-regulated kinase-1/2 activation is independent of angiotensin AT(1A) receptor internalisation. CELLULAR SIGNALLING, 13 , pp. 269-277.

Maqbool A; Hall AS; Ball SG; Balmforth AJ (1999) Common polymorphisms of beta(1)-adrenoceptor: identification and rapid screening assay. LANCET, 353 , pp. 897-897.

Fearon IM; Palmer ACV; Balmforth AJ; Ball SG; Varadi G; Peers C (1999) Modulation of recombinant human cardiac L-type Ca2+ channel alpha1C subunits by redox agents and hypoxia. . Journal of Physiology, 514 (3), pp. 629-637.

Fearon IM; Palmer ACV; Balmforth AJ; Mikala G; Ball SG; Peers C (1998) Inhibition of recombinant human cardiac L-type Ca 2+ channel alpha 1C subunits by 3-isobtyl-1-methylxanthine. . European Journal of Pharmacology, 342 (2-3), pp. 353-358.

Csikos T; Balmforth AJ; Grojec M; Gohlke P; Culman J; Unger T (1998) Angiotensin AT2 receptor degradation is prevented by ligand occupation. . Biochemical and Biophysical Research Communications, 243 (1), pp. 142-147.

Balmforth AJ; Shepherd FH; Warburton P; Ball SG (1997) Evidence of an important and direct role for protein kinase C in agonist-induced phosphorylation leading to desensitization of the angiotensin AT1A receptor. . British Journal of Pharmacology, 122 (7), pp. 1469-1477.

Balmforth AJ; Lee AJ; Shepherd FH; Warburton P; Donnelly D; Ball SG (1997) G-protein-coupled receptors for peptide hormones: angiotensin II receptors. . Biochemical Society Transactions, 25 (3), pp. 1041-1046.

Balmforth AJ; Lee AJ; Warburton P; Donnelly D; Ball SG (1997) The specificity of Peptide-Binding of the Angiotensin AT1 receptor is Dependent on an Interaction Between Transmembrane Helices III and VII. Journal of Biological Chemistry, 272 , pp. 4245-4251.

Balmforth AJ; Lee AJ; Warburton P; Donnelly D; Ball SG (1997) The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII. . Journal of Biological Chemistry, 272 (7), pp. 4245-4251.

Fearon IM; Palmer ACV; Balmforth AJ; Ball SG; Mikala G; Schwartz A; Peers C (1997) Hypoxia inhibits the recombinant alpha1C subunit of the human cardiac L-type Ca2+ channel. . Journal of Physiology, 500 (3), pp. 551-556.

McDonald RL; Balmforth AJ; Palmer ACV; Ball SG; Peers C; Vaughan PFT (1995) The effect of the angiotensin ll (AT 1A) receptor stably transfected into human neuroblastoma SH-SY5Y cells on oradrenaline release and changes in intracellular calcium. . Neuroscience Letters, 199 , pp. 115-118.

Ball SG; Wintersgill HP; Warburton P; Bryson S; Balmforth AJ (1995) Glucocorticoids regulate the expression of angiotensin AT1 receptors, in the human hepatoma cell line, PLC-PRF-5.. European Journal of Pharmacology, 288 , pp. 365-371.

Balmforth AJ; Lee AJ; Bajaj P; Dickinson CJ; Warburton P; Ball SG (1995) Functional domains of the c-terminus of the rat angiotensin AT1a receptor.. European Journal of Pharmacology, 291 , pp. 135-141.

Balmforth AJ; Bryson S; Aylett AJ; Warburton P; Ball SG; Pun KT; Middlemiss D; Drew GM (1994) Comparative pharmacology of recombinant rat AT1A, AT1B and human AT1 receptors expressed by transfected COS-M6 cells.. British Journal of Pharmacology, (112), pp. 277-281.

Balmforth AJ; Bryson S; Aylett AJ; Warburton P; Ball SG; Pun KT; Middlemiss D; Drew GM (1994) Comparative pharmacology of recominant rat AT 1A AT 1B and human AT1 receptors expressed by transfected COS-M6 cells. British Journal of Pharmacology, 112 , pp. 277-281.

Hall AS; Bryson S; Vaughan PFT; Ball SG; Balmforth AJ (1993) Pharmacological characterization of the dopamine receptor coupled to cyclic AMP formation expressed by rat mesenteric artery vascular smooth muscle cells in culture.. British Journal of Pharmacology, 110 , pp. 681-686.

Hall AS; Bryson S; Ball SG; Balmforth AJ (1993) Phenoxybenzamine mediated inhibition of the vascular dopamine D1 receptor.. European Journal of Pharmacology, 247 , pp. 249-255.

Bryson S; Warburton P; Wintersgill HP; Drew GM; Michel AD; Ball SG; Balmforth AJ (1992) Induction of the angiotensin AT2 receptor subtype expression by differentiation of the neuroblastoma x glioma hybrid, NG-108-15.. European Journal of Pharmacology, 225 , pp. 119-127.

Bryson S; Drew GM; Hall AS; Ball SG; Balmforth AJ (1992) Pharmacological characterization of the dopamine receptor expressed by rat glomerular mesangial cells in culture. . European Journal of Pharmacology, 225 , pp. 1-7.

Wintersgill HP; Warburton P; Bryson S; Ball SG; Balmforth AJ (1992) Characterisation of the angiotensin II receptor expressed by the human hepatoma cell line,PLC-PRF-5.. European Journal of Pharmacology, 227 , pp. 283-291.

Altiok N; Balmforth AJ; Fredholm BB (1992) Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon. . Acta Physiologica Scandinavica, 144 , pp. 55-63.

Hall AS; Bryson S; Ball SG; Balmforth AJ (1991) Pharmacological characterization of the B-adrenoceptor coupled to cyclic AMP formation expressed by rat mesentric artery vascular smooth muscle cells in culture. . Journal of Hypertension. Supplement, 9 (supplement 6), pp. S96-S97.

Medeiros MS; Balmforth AJ; Vaughan PFT; Turner AJ (1991) Hydrolis of atrial and brain natriuretic peptides by the human astrocytoma clone D384 and the neuroblastoma line SH-SY5Y. . Neuroendocrinology Letters, 54 , pp. 295-302.

Balmforth AJ; Warburton P; Ball SG (1990) Homologous Desensitization of the D1-dopamine receptor.. Journal of Neurochemistry, 55 , pp. 2111-2116.

Yasunari K; Kohno M; Balmforth AJ; Murakawa K; Yokokawa K; Kurihara N; Takeda T (1989) Effect of glucocorticoid on DA-1dopamine receptors on vascular smooth muscle cells. . Hypertension, 13 ( No 6 part 1), pp. 575-581.

Balmforth AJ; Yasunari K; Vaughan PFT; Ball SG (1989) Glucocorticoids vascular smooth muscle cells express dopamine and prostaglandin E1-mediated cyclic AMP formation by the cultured human astrocytoma clone D384. . Journal of Neurochemistry, 52 , pp. 1613-1618.

Balmforth AJ; Lyall F; Morton JJ; Ball SG (1988) Cultured mesenteric vascular smooth muscle cells express dopamine DA1-receptors. . European Journal of Pharmacology, 155 , pp. 305-308.

Balmforth AJ; Yasunari K; Vaughan PFT; Ball SG (1988) Characterization of dopamine and B-Adrenergic receptors linked to cyclic AMP formation in intact cells of the clone D384 derived from a human astrocytoma. . Journal of Neurochemistry, 51 , pp. 1510-1515.

Lyall F; Balmforth AJ; Morton JJ (1988) Specific binding of atrial natriuretic peptide increases cyclic GMP levels in human astrocytoma cells. . None, 117 , pp. 315-321.