My research focuses on investigating the mechanistic basis of cardiovascular control in health and disease. I have a particular interest in afferent nerve endings in the heart and lungs and how these fibres help regulate the cardiovascular system. Disruption of signals from these sensory nerves In heart failure may account for the detrimental shift in autonomic balance found in this condition. Mechanisms which could lead to an effective enhancement of afferent activity may prove to be of clinical relevance. As part of my research I use rodent models of hypertrophy and heart failure combined with techniques in nerve recording, telemetry, cardiac pressure volume loops pressure myography and exercise. I also have an interest in the adaptations found to hypoxia and have ongoing collaborations with colleagues from the UK , Peru, USA and Canada.

Benoist D; Stones R; Drinkhill MJ; Benson AP; Yang Z; Cassan C; Gilbert SH; Saint DA; Cazorla OF; Steele DS; Bernus O; White E (2012) Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension.. Am J Physiol Heart Circ Physiol, .

Moore JP; Hainsworth R; Drinkhill MJ (2011) Reflexes from pulmonary arterial baroreceptors in dogs: interaction with carotid sinus baroreceptors. JOURNAL OF PHYSIOLOGY-LONDON, 589 , pp. 4041-4052.

Benoist D; Stones R; Drinkhill MJ; Bernus O; White E (2011) Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.. Am J Physiol Heart Circ Physiol, 300 (6), pp. 2230-2237.

Benoist D; Stones R; Drinkhill M; Bernus O; White E (2011) Arrhythmogenic substrate in hearts of rats with monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 300 , pp. H2230-H2237.

Maqbool A; West RM; Galloway SL; Drinkhill MJ; Mary DASG; Greenwood JP; Ball SG (2010) Resting sympathetic nerve activity is related to age, sex and arterial pressure but not to alpha(2)-adrenergic receptor subtype. JOURNAL OF HYPERTENSION, 28 , pp. 2084-2093.

Ainscough JFX; Drinkhill MJ; Sedo A; Turner NA; Brooke DA; Balmforth AJ; Ball SG (2009) Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction. CARDIOVASCULAR RESEARCH, 81 , pp. 592-600.

Ainscough J; Drinkhill M; Sedo A; Turner N; Balmforth A; Ball S (2008) Local AT(1) receptor activity in adult myocardium influences cell size and ventricular function without pressure overload. HEART, 94 .

Mohammed MMJ; Myers DS; Sofola OA; Hainsworth R; Drinkhill MJ (2007) Vasodilator effects of leptin on canine isolated mesenteric arteries and veins. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 34 , pp. 771-774.

Hainsworth R; Drinkhill MJ (2007) Commentary on viewpoint "Human experimentation: No accurate, quantitative data"?. JOURNAL OF APPLIED PHYSIOLOGY, 102 , pp. 1293-1293.

Hainsworth R; Drinkhill MJ; Rivera-Chira M (2007) The autonomic nervous system at high altitude. CLINICAL AUTONOMIC RESEARCH, 17 , pp. 13-19.

Hainsworth R; Drinkhill MJ (2007) Commentary on viewpoint "human experimentation: No accurate, quantitative data?" [5]. Journal of Applied Physiology, 102 (3), pp. 1293-1293.

Hainsworth R; Drinkhill MJ (2006) Counterpoint: Active venoconstriction is not important in maintaining or raising end-diastolic volume and stroke volume during exercise and orthostasis. JOURNAL OF APPLIED PHYSIOLOGY, 101 , pp. 1264-1265.

Rothe CF; Hainsworth R; Drinkhill MJ (2006) Point:Counterpoint: Active venoconstriction is/is not important in maintaining or raising end-diastolic volume and stroke volume during exercise and orthostasis. Journal of Applied Physiology, 101 (4), pp. 1262-1266.

Kincaid K; Ward M; Nair U; Hainsworth R; Drinkhill M (2005) The coronary baroreflex in humans.. J Extra Corpor Technol, 37 (3), pp. 306-310.

Saha S; Drinkhill MJ; Moore JP; Batten TFC (2005) Central nucleus of amygdala projections to rostral ventrolateral medulla neurones activated by decreased blood pressure. EUROPEAN JOURNAL OF NEUROSCIENCE, 21 , pp. 1921-1930.

Kincaid K; Ward M; Nair U; Hainsworth R; Drinkhill M (2005) The coronary baroreflex in humans. Journal of Extra-Corporeal Technology, 37 (3), pp. 306-310.

Sedo AJ; Drinkhill MJ; Ball SG; Balmforth AJ; Ainscough JFX (2005) Conditional expression of human Angiotensin II type I receptors in adult mouse cardiac myocytes. Transgenic Research, 14 (4), pp. pp.520.

Drinkhill MJ; Wright CI; Hainsworth R (2001) Reflex vascular responses to independent changes in left ventricular end-diastolic and peak systolic pressures and inotropic state in anaesthetised dogs. JOURNAL OF PHYSIOLOGY-LONDON, 532 , pp. 549-561.

Sofola OA; Knill A; Drinkhill M; Hainsworth R (2000) Influence of dietary salt intake on responses of isolated mesenteric veins of the dog to noradrenaline and acetylcholine. JOURNAL OF PHYSIOLOGY-LONDON, 528P , pp. 113P-114P.

Sofola OA; Knill A; Drinkhill M; Hainsworth R (2000) Responses of endothelial factors in pressurised mesenteric arteries of Sprague-Dawley rats following a high salt diet. JOURNAL OF PHYSIOLOGY-LONDON, 526 , pp. 47P-47P.

Stephens N; Drinkhill MJ; Hall AS; Ball SG; Heagerty AM (1998) Structure and in vitro function of human subcutaneous small arteries in mild heart failure. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 274 , pp. C1298-C1305.

Doe CPA; Self DA; Drinkhill MJ; McMahon N; Myers DS; Hainsworth R (1998) Reflex vascular responses in the anesthetized dog to large rapid changes in carotid sinus pressure. American Journal of Physiology - Heart and Circulatory Physiology, 44 (4), pp. H1169-H1177.

McMahon NC; Drinkhill MJ; Hainsworth R (1996) Vascular responses to stimulation of carotid, aortic and coronary baroreceptors with pulsatile and nonpulsatile pressures in anaesthetized dogs. JOURNAL OF PHYSIOLOGY-LONDON, 497P , pp. P72-P72.

Drinkhill MJ; McMahon NC; Noble BJ; Myers DS; Hainsworth R (1996) A method for the independent application of pulsatile pressures to carotid, aortic and coronary baroreceptors in the anaesthetized dog. JOURNAL OF PHYSIOLOGY-LONDON, 497P , pp. P12-P12.

Noble BJ; Drinkhill MJ; Myers DS; Hainsworth R (1996) Active and passive volume responses in the abdominal circulation in anaesthetized dogs. JOURNAL OF PHYSIOLOGY-LONDON, 497P , pp. P68-P69.

Doe CP; Drinkhill MJ; Myers DS; Self DA; Hainsworth R (1996) Reflex vascular responses to abdominal venous distension in the anesthetized dog.. Am J Physiol, 271 (3 Pt 2), pp. H1049-H1056.

Doe CPA; Drinkhill MJ; Myers DS; Self DA; Hainsworth R (1996) Reflex vascular responses to abdominal venous distension in the anesthetized dog. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 271 , pp. H1049-H1056.

Doe CPA; Drinkhill MJ; Myers DS; Self DA; Hainsworth R (1996) Reflex vascular responses to abdominal venous distension in the anesthetized dog. American Journal of Physiology - Heart and Circulatory Physiology, 40 (3), pp. H1049-H1056.

MCMAHON N; DRINKHILL M; HAINSWORTH R (1995) RECOVERY OF SYMPATHETIC EFFERENT ACTIVITY FOLLOWING STIMULATION OF CORONARY AND CAROTID BARORECEPTORS IN ANESTHETIZED DOGS. JOURNAL OF PHYSIOLOGY-LONDON, 489P , pp. P160-P160.

DOE C; SELF D; DRINKHILL M; MYERS D; HAINSWORTH R (1995) SPLANCHNIC ARTERIAL REFLEXES MAY CONTRIBUTE TO CONTROL OF VASCULAR-RESISTANCE IN THE ANESTHETIZED DOG. JOURNAL OF PHYSIOLOGY-LONDON, 483P , pp. P144-P145.

QUARTAROLI M; DOE C; MYERS D; DRINKHILL M; CEVESE A; VACCA G; MARY D (1994) EFFECT OF CALCIUM-CHANNEL INHIBITORS ON REFLEX RENAL NERVE RESPONSES IN ANESTHETIZED DOGS. MEDICAL SCIENCE RESEARCH, 22 , pp. 645-648.

DRINKHILL M; MOORE J; HAINSWORTH R (1993) AFFERENT DISCHARGES FROM CORONARY ARTERIAL AND VENTRICULAR RECEPTORS IN ANESTHETIZED DOGS. JOURNAL OF PHYSIOLOGY-LONDON, 472 , pp. 785-799.

ALTIMMAN J; DRINKHILL M; HAINSWORTH R (1993) REFLEX RESPONSES TO STIMULATION OF MECHANORECEPTORS IN THE LEFT-VENTRICLE AND CORONARY-ARTERIES IN ANESTHETIZED DOGS. JOURNAL OF PHYSIOLOGY-LONDON, 472 , pp. 769-783.

SELF D; DRINKHILL M; MOORE J; HAINSWORTH R (1993) DEVELOPMENT OF AN ACUTE MODEL USING ANESTHETIZED ANIMALS TO MIMIC THE HEMODYNAMIC SITUATIONS SEEN UNDER INCREASED GRAVITATIONAL LOADS. JOURNAL OF PHYSIOLOGY-LONDON, 467 , pp. P143-P143.

MOORE J; DRINKHILL M; HAINSWORTH R (1993) VASOPRESSIN ENHANCES THE REFLEX VASODILATATION TO STIMULATION OF CORONARY MECHANORECEPTORS IN THE ANESTHETIZED DOG. JOURNAL OF PHYSIOLOGY-LONDON, 467 , pp. P207-P207.

COULSHED D; COWAN J; DRINKHILL M; HAINSWORTH R (1992) THE EFFECTS OF VENTRICULAR END-DIASTOLIC AND SYSTOLIC PRESSURES ON ACTION-POTENTIAL AND DURATION IN ANESTHETIZED DOGS. JOURNAL OF PHYSIOLOGY-LONDON, 457 , pp. 75-91.

HAINSWORTH R; DRINKHILL M; MOORE J (1992) RESPONSES OF VENTRICULAR AFFERENT NERVES TO CHEMICAL AND MECHANICAL STIMULATION. FASEB JOURNAL, 6 , pp. A1735-A1735.

MOORE J; DRINKHILL M; HAINSWORTH R (1992) AN ELECTROPHYSIOLOGICAL STUDY OF VENTRICULAR RECEPTORS IN ANESTHETIZED DOGS. JOURNAL OF PHYSIOLOGY-LONDON, 446 , pp. P544-P544.

CEVESE A; DRINKHILL M; MARY D; PATEL P; SCHENA F; VACCA G (1991) THE EFFECT OF DISTENSION OF THE URINARY-BLADDER ON CORONARY BLOOD-FLOW IN ANESTHETIZED DOGS. EXPERIMENTAL PHYSIOLOGY, 76 , pp. 409-421.

DRINKHILL M; ALTIMMAN J; HAINSWORTH R (1991) REFLEX VASODILATATION TO INDEPENDENT CHANGES IN AORTIC ROOT AND LEFT-VENTRICULAR PRESSURES IN THE ANESTHETIZED DOG. JOURNAL OF PHYSIOLOGY-LONDON, 438 , pp. P86-P86.

COULSHED D; DRINKHILL M; COWAN J; HAINSWORTH R (1991) AN INVESTIGATION OF SOME OF THE MECHANISMS LINKING CARDIAC ACTION-POTENTIAL DURATION TO MECHANICAL EVENTS IN THE ISOLATED GUINEA-PIG HEART AND THE HEART OF THE ANESTHETIZED DOG. JOURNAL OF PHYSIOLOGY-LONDON, 438 , pp. P90-P90.

COULSHED D; DRINKHILL M; COWAN J; HAINSWORTH R (1990) CHANGES IN LEFT-VENTRICULAR PRELOAD AND AFTERLOAD HAVE OPPOSITE EFFECTS ON THE ACTION-POTENTIAL DURATION OF THE INSITU DOG HEART. CLINICAL SCIENCE, 79 , pp. P24-P24.

VACCA G; DRINKHILL M; CEVESE A; PATEL P; SCHENA F; MARY D (1990) URINARY-BLADDER DISTENSION REFLEXLY DECREASES CORONARY BLOOD-FLOW IN THE ANESTHETIZED DOG. JOURNAL OF PHYSIOLOGY-LONDON, 429 , pp. P82-P82.

CARE A; ABBAS S; PICKARD D; BARRI M; DRINKHILL M; FINDLAY J; WHITE I; CAPLE I (1990) STIMULATION OF OVINE PLACENTAL TRANSPORT OF CALCIUM AND MAGNESIUM BY MIDMOLECULE FRAGMENTS OF HUMAN PARATHYROID HORMONE-RELATED PROTEIN. EXPERIMENTAL PHYSIOLOGY, 75 , pp. 605-608.

Patel PK; Drinkhill MJ; Ball SG; Mary DASG (1990) The angiotensin converting enzyme inhibitor ramiprilat attenuates baroreflex responses of efferent cardiac vagal activity in anaesthetised dogs. Medical Science Research, 18 (20), pp. 793-795.

DRINKHILL M; KAYE D; MARY D; PATEL P (1989) MEASUREMENT OF REFLEX CHANGES IN CORONARY BLOOD-FLOW IN THE ANESTHETIZED DOG. JOURNAL OF PHYSIOLOGY-LONDON, 416 , pp. P7-P7.

RAMADAN M; DRINKHILL M; MARY D (1989) THE EFFECT OF DISTENSION OF THE URINARY-BLADDER ON ACTIVITY IN EFFERENT VAGAL FIBERS IN ANESTHETIZED DOGS. QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 74 , pp. 493-501.

DRINKHILL M; VACCA G; MARY D (1989) EFFERENT LIMB OF THE ATRIAL RECEPTOR REFLEX DECREASE IN PLASMA-RENIN ACTIVITY IN ANESTHETIZED DOGS. QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 74 , pp. 503-509.

DRINKHILL M; MARY D (1989) THE EFFECT OF STIMULATION OF THE ATRIAL RECEPTORS ON PLASMA-CORTISOL LEVEL IN THE DOG. JOURNAL OF PHYSIOLOGY-LONDON, 413 , pp. 299-313.

DRINKHILL M (1989) CORRECTION. JOURNAL OF PHYSIOLOGY-LONDON, 412 , pp. 557-557.

DRINKHILL M; MARY D; RAMADAN M; VACCA G (1989) THE EFFECT OF DISTENSION OF THE URINARY-BLADDER ON ACTIVITY IN EFFERENT RENAL FIBERS IN ANESTHETIZED DOGS. JOURNAL OF PHYSIOLOGY-LONDON, 409 , pp. 357-369.

DRINKHILL M; KAYE D; MARY D (1989) THE EFFECT OF STIMULATION OF LEFT ATRIAL RECEPTORS ON CORONARY BLOOD-FLOW IN ANESTHETIZED DOGS. JOURNAL OF PHYSIOLOGY-LONDON, 408 , pp. 45-56.

Drinkhill MJ; Kaye D; Patel P; Mary DASG (1989) The left atrial receptor-coronary vasoconstriction reflex. Medical Science Research, 17 (18), pp. 775-776.

Vacca G; Cevese A; Drinkhill MJ; Mary DASG; Schena F; Vono P (1989) Diastolic coronary pressure-flow relation during changes in left ventricular pressure. Medical Science Research, 17 (22), pp. 967-968.

DRINKHILL M; KAYE D; MARY D (1988) REFLEX DECREASE IN CORONARY FLOW FROM ATRIAL RECEPTOR STIMULATION IN THE ANESTHETIZED DOG. JOURNAL OF PHYSIOLOGY-LONDON, 407 , pp. P140-P140.

DRINKHILL M; HICKS M; MARY D; PEARSON M (1988) THE EFFECT OF STIMULATION OF THE ATRIAL RECEPTORS ON PLASMA-RENIN ACTIVITY IN THE DOG. JOURNAL OF PHYSIOLOGY-LONDON, 398 , pp. 411-421.

Drinkhill M; Kaye D; Mary DASG (1988) Effect of atrial receptor stimulation on diastolic coronary blood flow in anaesthetized dogs. Medical Science Research, 16 (12), pp. 645-646.

DRINKHILL M; HICKS M; MARY D (1987) LEFT ATRIAL RECEPTORS AND PLASMA-CORTISOL LEVELS IN THE DOG. JOURNAL OF PHYSIOLOGY-LONDON, 390 , pp. P230-P230.

DRINKHILL M; HASSAN A; HICKS M; MARY D; RAMADAN M; VACCA G (1987) DISTENSION OF THE URINARY-BLADDER IN THE STUDY OF RELATED CARDIOVASCULAR REFLEXES IN THE DOG. JOURNAL OF PHYSIOLOGY-LONDON, 386 , pp. P3-P3.