Sikha Saha
University Senior Fellow and Director of International Postgraduate Medical Training
Cardiovascular and Neuronal Remodelling
Qualifications: BSc (Hons), MSc, PhD, FHEA
Email: S.Saha@leeds.ac.uk
Telephone: 0113 343 4817
Research Area
Cerebrovascular and cardiovascular disorders and related neurodegenerative diseases
Details
My research interest also includes novel Laser engineering approaches for detection and quantification of functionalised metabolites/ biomarkers of these diseases. In collaboration with the Engineering Department and with the support of the BHRC funding, we have successfully completed ex-vivo ischemic brain tissue metabolite analysis, which has given us confidence to progress it to the next level of more in-depth in vivo studies using ischemic/thrombotic models. We have also performed laser spectroscopic analysis of metabolites conjugated with rare-earth ions which enable strong light emission through skin when excited with an external laser source for providing novel pathways for non-invasive transcutaneous detection and imaging of metabolites. Currently, in collaboration with Professor Animesh Jha and Dr Gin Jose in the Institute for Materials Research I am working towards commercialization of these novel approaches.
Publications
Recent
Saha S; Batten TFC; McWilliam PN Glutamate, * -aminobutyric acid and tachykinin-immunoreactive synapses in the cat nucleus tractus solitarii.. JOURNAL OF NEUROCYTOLOGY, 24 , pp. 55-74.
All
Ketheeswaranathan P; Turner NA; Spary EJ; Batten TFC; McColl BW; Saha S (2011) Changes in glutamate transporter expression in mouse forebrain areas following focal ischemia. BRAIN RESEARCH, 1418 , pp. 93-103.
Batten TFC; Pow DV; Saha S (2010) Co-localisation of markers for glycinergic and GABAergic neurones in rat nucleus of the solitary tract: Implications for co-transmission. JOURNAL OF CHEMICAL NEUROANATOMY, 40 , pp. 160-176.
Saha S; Gamboa-Esteves FO; Batten TFC (2010) Differential distribution of 5-HT1A and 5-HT1B-like immunoreactivities in rat central nucleus of the amygdala neurones projecting to the caudal dorsomedial medulla oblongata. BRAIN RESEARCH, 1330 , pp. 20-30.
Batten TFC; Pow DV; Saha S (2010) Co-localisation of markers for glycinergic and GABAergic neurones in rat nucleus of the solitary tract: Implications for co-transmission. Journal of Chemical Neuroanatomy, 40 (2), pp. 160-176.
Das KK; Saha S (2010) L-ascorbic acid and alpha tocopherolsupplementation and antioxidant status in nickel or lead-exposed rat brain tissue. Journal of Basic and Clinical Physiology and Pharmacology, 21 (4).
Das KK; Saha S (2010) L-ascorbic acid and alpha tocopherol supplementation and antioxidant status in nickel- or lead-exposed rat brain tissue. Journal of Basic and Clinical Physiology and Pharmacology, 21 (4), pp. 325-346.
Spary EJ; Maqbool A; Saha S; Batten TFC (2008) Increased GABA(B) receptor subtype expression in the nucleus of the solitary tract of the spontaneously hypertensive rat. JOURNAL OF MOLECULAR NEUROSCIENCE, 35 , pp. 211-224.
Saha S; Drinkhill MJ; Moore JP; Batten TFC (2005) Central nucleus of amygdala projections to rostral ventrolateral medulla neurones activated by decreased blood pressure. EUROPEAN JOURNAL OF NEUROSCIENCE, 21 , pp. 1921-1930.
Gloveli T; Dugladze T; Saha S; Monyer H; Heinemann U; Traub RD; Whittington MA; Buhl EH (2005) Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro. JOURNAL OF PHYSIOLOGY-LONDON, 562 , pp. 131-147.
Saha S (2005) Role of the central nucleus of the amygdala in the control of blood pressure: Descending pathways to medullary cardiovascular nuclei. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 32 , pp. 450-456.
Henderson Z; Fiddler G; Saha S; Boros A; Halasy K (2004) A parvalbumin-containing, axosomatic synaptic network in the rat medial septum: relevance to rhythmogenesis.. Eur J Neurosci, 19 (10), pp. 2753-2768.
Saha S; Spary EJ; Maqbool A; Asipu A; Corbett EKA; Batten TFC (2004) Increased expression of AMPA receptor subunits in the nucleus of the solitary tract in the spontaneously hypertensive rat. MOLECULAR BRAIN RESEARCH, 121 , pp. 37-49.
Saha S; Henderson Z; Batten TFC (2002) Somatostatin immunoreactivity in axon terminals in rat nucleus tractus solitarii arising from central nucleus of amygdala: coexistence with GABA and postsynaptic expression of sst(2A) receptor. JOURNAL OF CHEMICAL NEUROANATOMY, 24 , pp. 1-13.
Batten TFC; Gamboa-Esteves FO; Saha S (2002) Erratum: Evidence for peptide co-transmission in retrograde- and anterograde-labelled central nucleus of amygdala neurones projecting to NTS (Autonomic Neuroscience (2002) 98 (28-32) PII: S1566070202000267). Autonomic Neuroscience: Basic and Clinical, 99 (2), pp. 141-141.
Saha S; Sieghart W; Fritschy JM; McWilliam PN; Batten TFC (2001) gamma-Aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. MOLECULAR AND CELLULAR NEUROSCIENCE, 17 , pp. 241-257.
Saha S; Sieghart W; Fritschy J; McWilliam PN; Batten TFC (2001) γ-Aminobutyric acid receptor (GABAA) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. Molecular and Cellular Neuroscience, 17 (1), pp. 241-257.
Saha S; Batten TFC; Henderson Z (2000) A GABAergic projection from the central nuclus of the amygdala to the nucleus of the solitary tract: a combined anterograde tracing and electron microscopic immunohistochemical study.. Neuroscience, 99 (4), pp. 613-626.
Saha S; Batten TFC; McWilliam PN (1999) Glycine-immunoreactive synaptic terminals in the nucleus tractus solitarii of the cat: ultrastructure and relationship to GABA-immunoreactive terminals. . Synapse (New York), 33 (3), pp. 192-206.
Saha S; Batten TFC; McWilliam PN (1995) Glutamate-immunoreactivity in identified vagal afferent terminals of the cat: a study combining horseradish peroxidase tracing and postembedding electron microscopic immunogold staining. . Experimental Physiology, 80 , pp. 193-202.
Saha S (1991) Quantitative analysis and postsynaptic targets of GABA-immunoreactive boutons within the rat trigeminal motor nucleus.. Brain Research, 561 (1), pp. 128-138.
Saha S (1991) Light and electron microscopical localisation of 5-HT-immunoreactive boutons in the rat trigeminal motor nucleus.. Brain Research, 559 (1), pp. 145-148.
Saha S (1988) Visualisation of CGRP and ChAT-like immunoreactivity in identified trigeminal neurones by combined peroxidase and alkaline phosphatase enzymatic reactions.. Brain Research, 447 (2), pp. 314-324.
Saha S; Batten TFC; McWilliam PN Glutamate, * -aminobutyric acid and tachykinin-immunoreactive synapses in the cat nucleus tractus solitarii.. JOURNAL OF NEUROCYTOLOGY, 24 , pp. 55-74.
Teaching Commitments
Course Manager for MBChB Pre-Xmas RESS year 2 and year 3 students (total 500 students)
Personal tutorial guidance for MSc research student and undergraduate medical students
Quality management of Institute’s MSC Courses
MBChB year 1 Integrated Medical Sciences
SSC1.1 and SSC 2.1 students
BSc Intercalated students
MSC Project Students in Pharmaceutical Science & Engineering
LURE Scolarship students
European Education Exchange programme
